Retinal Görsel Protezler (Biyonik Göz)

Yazarlar

Hakan Koç
https://orcid.org/0000-0003-1241-1686

Özet

Retinal protezler, retinitis pigmentosa ve yaşa bağlı makula dejenerasyonu gibi ciddi retina hastalıkları nedeniyle görme kaybı yaşayan bireylere temel görme duyusunu geri kazandırmak amacıyla geliştirilen teknolojik cihazlardırBu sistemler; elektrotların yerleşimine göre epiretinal, subretinal ve suprakoroidal olmak üzere üç ana gruba ayrılırken, günümüzde klinik olarak en yaygın kullanılan sistem FDA onaylı Argus II'dirElektriksel uyarım prensibiyle çalışan bu "biyonik gözler", hastaların hareket yönünü seçebilmelerine, ışık algısı kazanmalarına ve günlük yaşamda yön belirleme kabiliyetlerini artırmalarına yardımcı olmaktadır.

 

Retinal prostheses are technological devices designed to restore basic vision in individuals with severe vision loss due to degenerative retinal diseases such as retinitis pigmentosa and age-related macular degenerationThese systems are categorized into three main types based on electrode placement—epiretinal, subretinal, and suprachoroidal—with the FDA-approved Argus II being the most clinically established systemOperating on the principle of electrical stimulation, these "bionic eyes" enable patients to detect the direction of movement, perceive light, and improve their ability to navigate and orient themselves.

Referanslar

O. Lauren N. Aytona,*, Nick Barnesb, c, Gislin Dagnelied, Takashi Fujikadoe, Georges Goetzf, Ralf Hornigg, Bryan W. Jonesh, Mahiul M.K. Muqiti, j, Daniel L. Rathbunk, l, Katarina Stingll, James D. Weilandm, Matthew A. Petoen, “HHS Public Access,” Physiol. Behav., vol. 176, no. 3, pp. 139–148, 2019, doi: 10.1016/j.clinph.2019.11.029.An.

S. Y. Kim et al., “Morphometric analysis of the macula in eyes with disciform age-related macular degeneration,” Retina, vol. 22, no. 4, pp. 471–477, 2002, doi: 10.1097/00006982-200208000-00012.

A. Santos, M. S. Humayun, E. De Juan, M. J. Marsh, I. B. Klock, and A. H. Milam, “Retinitis layer and the inner nuclear layer,” Control, 1997.

S. Klauke et al., “Stimulation with a wireless intraocular epiretinal implant elicits visual percepts in blind humans,” Investig. Ophthalmol. Vis. Sci., vol. 52, no. 1, pp. 449–455, 2011, doi: 10.1167/iovs.09-4410.

D. Güven, O. No, S. Tİryakİ, and D. Orcid, “Retinal Prosthesis in the Treatment of Retinitis Pigmentosa,” Güncel Retin. Derg. (Current Retin. Journal), vol. 5, no. 2, pp. 140–149, 2021, doi: 10.37783/crj-0252.

A. T. Chuang, C. E. Margo, and P. B. Greenberg, “Retinal implants: A systematic review,” Br. J. Ophthalmol., vol. 98, no. 7, pp. 852–856, 2014, doi: 10.1136/bjophthalmol-2013-303708.

Y. H. L. Luo and L. da Cruz, “The Argus® II Retinal Prosthesis System,” Prog. Retin. Eye Res., vol. 50, pp. 89–107, 2016, doi: 10.1016/j.preteyeres.2015.09.003.

N. Acar, “Görsel Protezlerde Klinik Sonuçlar ve Güncel Durum,” pp. 339–348, 2019.

“Argus II Retinal Prosthesis System Surgeon Manual.”

A. P. Finn, D. S. Grewal, and L. Vajzovic, “Argus II retinal prosthesis system: A review of patient selection criteria, surgical considerations, and post-operative outcomes,” Clin. Ophthalmol., vol. 12, pp. 1089–1097, 2018, doi: 10.2147/OPTH.S137525.

A. P. Finn, C. Viehland, O. M. Carrasco-Zevallos, J. A. Izatt, C. A. Toth, and L. Vajzovic, “Four-Dimensional Microscope-Integrated OCT Use in Argus II Placement,” Ophthalmol. Retin., vol. 2, no. 5, pp. 510–511, 2018, doi: 10.1016/j.oret.2017.10.015.

D. K. S. Nishijima David L; Wisner, David H; Holmes, James F, “HHS Public Access,” Physiol. Behav., vol. 176, no. 4, pp. 139–148, 2016, doi: 10.1111/cxo.12242.FLORA.

M. Gerhardt, J. Alderman, and A. Stett, “Electric field stimulation of bipolar cells in a degenerated retina-A theoretical study,” IEEE Trans. Neural Syst. Rehabil. Eng., vol. 18, no. 1, pp. 1–10, 2010, doi: 10.1109/TNSRE.2009.2037323.

R. Daschner, A. Rothermel, R. Rudorf, S. Rudorf, and A. Stett, “Functionality and performance of the subretinal implant chip alpha AMS,” Sensors Mater., vol. 30, no. 2, pp. 179–192, 2018, doi: 10.18494/SAM.2018.1726.

T. L. Edwards et al., “Assessment of the Electronic Retinal Implant Alpha AMS in Restoring Vision to Blind Patients with End-Stage Retinitis Pigmentosa,” Ophthalmology, vol. 125, no. 3, pp. 432–443, 2018, doi: 10.1016/j.ophtha.2017.09.019.

E. Bloch, Y. Luo, and L. da Cruz, “Advances in retinal prosthesis systems,” Ther. Adv. Ophthalmol., vol. 11, p. 251584141881750, 2019, doi: 10.1177/2515841418817501.

K. Stingl et al., “Subretinal Visual Implant Alpha IMS - Clinical trial interim report,” Vision Res., vol. 111, pp. 149–160, 2015, doi: 10.1016/j.visres.2015.03.001.

L. N. Ayton et al., “First-in-human trial of a novel suprachoroidal retinal prosthesis,” PLoS One, vol. 9, no. 12, pp. 1–26, 2014, doi: 10.1371/journal.pone.0115239.

G. J. S. H. L. A. P. A. X. N.-L. E. B. N. B. Lauren N. Ayton, Artificial Vision. 2016.

T. Fujikado et al., “One-year outcome of 49-channel suprachoroidal–transretinal stimulation prosthesis in patients with advanced retinitis pigmentosa,” Investig. Ophthalmol. Vis. Sci., vol. 57, no. 14, pp. 6147–6157, 2016, doi: 10.1167/iovs.16-20367.

Sayfalar

331-338

Gelecek

11 Nisan 2022

Lisans

Lisans