Obezite Tedavisinde Endoskopik İntragastrik Botulinum Toksini Uygulanmasının Yeri
Özet
Obezite tedavisinde endoskopik intragastrik botulinum toksini (BtXA) uygulaması, cerrahi yöntemlere göre daha az invaziv, geri dönüşümlü ve güvenli bir alternatif olarak öne çıkmaktadır. Mide duvarına yapılan enjeksiyonlar, asetilkolin salınımını engelleyerek mide boşalmasını geciktirmekte, iştahı azaltmakta ve ghrelin hormonu seviyelerini düşürerek kilo kaybına yardımcı olmaktadır. Bilimsel çalışmalar, özellikle antrum ve fundus bölgelerine yapılan çoklu enjeksiyonların üç ile altı ay süresince anlamlı kilo kaybı sağladığını ve yan etki oranının oldukça düşük olduğunu göstermektedir.
Endoscopic intragastric botulinum toxin (BtXA) application stands out as a less invasive, reversible, and safe alternative to surgical methods in the treatment of obesity. Injections into the gastric wall inhibit acetylcholine release, delaying gastric emptying, reducing appetite, and assisting weight loss by lowering ghrelin hormone levels. Scientific studies demonstrate that multiple injections, particularly into the antrum and fundus regions, provide significant weight loss over a period of three to six months with a very low rate of side effects.
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