Geçmişten Günümüze Dondurulmuş Embriyo Transferi
Özet
Yardımcı Üreme Teknikleri (YÜT) alanındaki teknolojik ilerlemelerle birlikte, dondurulmuş çözünmüş embriyo transferleri (DÇET) günümüzde klinik başarıyı artıran temel uygulamalardan biri haline gelmiştir. Özellikle vitrifikasyon (hızlı dondurma) yöntemi, hücre içi buz kristali oluşumunu engelleyerek embriyoların canlılık oranlarını yavaş dondurma tekniğine göre daha etkili bir şekilde korumaktadır. DÇET; aşırı uyarılma sendromu riskini azaltması, endometriyal uyumu optimize etmesi ve genetik tarama süreçlerine imkan tanıması gibi tıbbi avantajlarının yanı sıra, çiftlere ekonomik ve psikolojik kolaylıklar sağlamaktadır.
With technological advancements in Assisted Reproductive Techniques (ART), frozen-thawed embryo transfer (FET) has become a primary clinical application that significantly enhances success rates. The vitrification method, in particular, preserves embryo viability more effectively than slow freezing by preventing intracellular ice crystal formation. Beyond its medical benefits—such as reducing hyperstimulation risk, optimizing endometrial receptivity, and facilitating genetic screening—FET provides couples with substantial economic and psychological advantages by streamlining the IVF process.
Referanslar
Martin L.J., Delaying, debating and declining motherhood. Culture, Health & Sexuality, 2020: p. 1-16.
Mascarenhas M.N., Cheung H., Mathers C. D., et al., Measuring infertility in populations: constructing a standard definition for use with demographic and reproductive health surveys. Popul Health Metr, 2012. 10(1): p. 17.
Fishel S., First in vitro fertilization baby—this is how it happened. Fertility and sterility, 2018. 110(1): p. 5-11.
IVF WordWide (10.09.2021 tarihinde https://ivf-worldwide.com/survey/frozen-thawed-embryotransfer/results-frozen-thawed–embryo-transfer.html. adresinden alınmıştır.)
Benson E.E., Cryopreservation, in Plant conservation biotechnology. 1999, CRC Press. p. 109-122.
Pegg D.E., The history and principles of cryopreservation. Semin Reprod Med, 2002. 20(1): p. 5-13.
Mantegazza P., Fisiologia sullo sperma umano. Rendic Reale Instit Lomb, 1866. 3: p. 183-186.
Chang M., Fertilizability of rabbit germ cells. Mammalian germ cells, 1953: p. 226-242.
Faulkner K.K., Effect of glycerol in protecting tissue homogenates against the effects of freezing. 1955: The University of Oklahoma.
Chang M.C., The effects of low temperature on fertilized rabbit ova in vitro, and the normal development of ova kept at low temperature for several days. J Gen Physiol, 1948. 31(5): p. 385-410.
Wilmut I., The effect of cooling rate, warming rate, cryoprotective agent and stage of development of survival of mouse embryos during freezing and thawing. Life Sciences, 1972. 11(22): p. 1071-1079.
Whittingham D., S. Leibo and P. Mazur, Survival of mouse embryos frozen to-1960 and-2960. Science, 1972. 178: p. 414.
Zeilmaker G.H., Alberda A. T., Van G. et al., Two pregnancies following transfer of intact frozen-thawed embryos. Fertility and sterility, 1984. 42(2): p. 293-296.
Palasz A.T. and R.J. Mapletoft, Cryopreservation of mammalian embryos and oocytes: recent advances. Biotechnology Advances, 1996. 14(2): p. 127-149.
Bagis H., Odaman H., Sagirkaya, H., et al., Production of transgenic mice from vitrified pronuclear‐stage embryos. Molecular reproduction and development, 2002. 61(2): p. 173-179.
Agca Y., Post-thaw survival and pregnancy rates of intact and biopsied and sexed in vitro produced bovine embryos after vitrification (Master Thesis). University of Wisconsin-Madison, Madison WI, USA, 1994.
Delilbaşı L., Tüp Bebek Yardımcı Üreme Tekniklerinde Laboratuvar Yöntemleri. Baysed Yayın 1997. No:10.
Trounson A., Leeton J., Besanko M., et al., Pregnancy established in an infertile patient after transfer of a donated embryo fertilised in vitro. Br Med J (Clin Res Ed), 1983. 286(6368): p. 835-838.
Van der Elst J., Camus M., Van den A., et al., Prospective randomized study on the cryopreservation of human embryos with dimethylsulfoxide or 1, 2-propanediol protocols. Fertility and sterility, 1995. 63(1): p. 92-100.
Camus M., Van den A., Van der Elst J., et al., Human embryo viability after freezing with dimethylsulfoxide as a cryoprotectant. Fertility and Sterility, 1989. 51(3): p. 460-465.
Lassalle B., Testart J. and Renard J.-P., Human embryo features that influence the success of cryopreservation with the use of 1, 2 propanediol. Fertility and sterility, 1985. 44(5): p. 645-651.
AbdelHafez F.F., Desai N., Abou-Setta, A. M., et al., Slow freezing, vitrification and ultra-rapid freezing of human embryos: a systematic review and meta-analysis. Reproductive biomedicine online, 2010. 20(2): p. 209-222.
Rall W.F., Cryopreservation of oocytes and embryos: methods and applications. Animal Reproduction Science, 1992. 28(1-4): p. 237-245.
Feichtinger W., C. Hochfellner and Ferstl U., Clinical experience with ultra-rapid freezing of embryos. Human Reproduction, 1991. 6(5): p. 735-736.
Sutton R.L., Critical cooling rates to avoid ice crystallization in solutions of cryoprotective agents. Journal of the Chemical Society, Faraday Transactions, 1991. 87(1): p. 101-105.
Towill L., Cryopreservation by vitrification, in Genetic preservation of plant cells in vitro. 1995, Springer. p. 99-111.
Vajta G., Hyttel P., and Callesen H., Morphological changes of in‐vitro‐produced bovine blastocysts after vitrification, in‐straw direct rehydration, and culture. Molecular Reproduction and Development: Incorporating Gamete Research, 1997. 48(1): p. 9-17.
Shaw P., Fuller B.J., Bernard A., et al., Vitrification of mouse oocytes: improved rates of survival, fertilization, and development to blastocysts. Molecular reproduction and development, 1991. 29(4): p. 373-378.
Chian R.C., Masashige K., Leonard T., et al., High survival rate of bovine oocytes matured in vitro following vitrification. Journal of reproduction and development, 2004. 50(6): p. 685-696.
Kolibianakis E.M., Venetis C.A., and Tarlatzis B.C., Cryopreservation of human embryos by vitrification or slow freezing: which one is better? Curr Opin Obstet Gynecol, 2009. 21(3): p. 270-4.
Bergenheim S.J., Marte S., Nina P., et al., Immediate versus postponed frozen embryo transfer after IVF/ICSI: a systematic review and meta-analysis. Human Reproduction Update, 2021.
Kalinderis M., Kallirhoe K., Garima S., et al., When Should We Freeze Embryos? Current Data for Fresh and Frozen Embryo Replacement IVF Cycles. Reproductive Sciences, 2021: p. 1-12.
Hsieh H.-C., Chun-I L., En-Yu L., et al., Estimating the causal effect of embryo transfer day on clinical in vitro fertilization outcomes using propensity score matching. BMC Pregnancy and Childbirth, 2021. 21(1): p. 1-10.
Hao Y., Xiaoyu L., Fei K., et al., Maternal and neonatal outcomes following blastocyst biopsy for preimplantation genetic testing in single frozen-thawed embryo transfer cycles. Reproductive BioMedicine Online, 2021.
