Periodontal Hastalıklar
Özet
Periodontal hastalıklar, dünya genelinde sık görülen, sadece ağız sağlığını değil kardiyovasküler sistem, diyabet ve romatoid artrit gibi çeşitli sistemik hastalıkları da etkileyen karmaşık enflamatuar durumlardır. Bu hastalıkların etyolojisinde genetik yatkınlık, kötü beslenme, sigara kullanımı ve hijyen eksikliği gibi çevresel faktörler rol oynamakta olup, sitrülinizasyon süreci ve immün sistem dengesizlikleri patogenezde kritik öneme sahiptir. Tedavi yaklaşımı, sadece lokal müdahalelerle sınırlı kalmayıp, bütüncül tıp prensipleri çerçevesinde bağırsak florasının düzenlenmesi, beslenme alışkanlıklarının iyileştirilmesi ve sistemik inflamasyonun yönetilmesini gerektirir. Erken teşhis ve doğru tedavi protokolleri, hem oral hem de genel sağlığın korunmasında hayati rol oynamaktadır.
Periodontal diseases are prevalent, complex inflammatory conditions that significantly affect not only oral health but also systemic well-being, with links to cardiovascular disease, diabetes, and rheumatoid arthritis. The etiology involves a combination of genetic susceptibility and environmental factors such as poor nutrition, smoking, and hygiene, where citrullination and immune system imbalances play a critical role in pathogenesis. Effective management requires a holistic approach that extends beyond local interventions to include gut flora regulation, dietary improvements, and the control of systemic inflammation. Early diagnosis and comprehensive treatment protocols are essential for maintaining both oral and overall systemic health.
Referanslar
Arikan S, Sancak B, Hasçelik G, Günalp A, Candida albicans İzolatlarında Fosfolipaz Aktivitesinin Saptanması;
Bodur A, Turgut Z, Periodontitis; Kardiyovasküler Hastalıklar İçin Bir Risk Faktörü Müdür? GÜ Diş Hek Fak Derg 26(3):195-199,200
Bright R. Proudman S.M. Rosenstein E.D. . Bartold P.M, Is there a link between carbamylation and citrullination in periodontal disease and rheumatoid arthritis? Medical Hypotheses, Volume 84, Issue 6, June 2015, Pages 570-576
Cutler CW, Jotwani R. Dendritic cells at the oral mucosal interface. J Dent Res. 2006;85:678–89.)
Çalışır M, Talmaç AC, Dişhekimliği Fakültesine Başvuran Hastalarda Periodontal Durum ve Sistemik Hastalıkların Değerlendirilmesi, Adıyaman Üni. Sağlık Bilimleri Derg, 2018;4 (2): 738-749.
Dayan İ, Tıkız C, Taneli F, Ulman C, Ulutaş G, Tüzün Ç, Relationship Between Cyclic Citrullinated Peptide Antibodies Positivity and HLA-DRB1 Shared Epitope Alleles in Patients with Rheumatoid Arthritis in Turkey, Turk J Rheumatol 2010; 25: 12-18
Della Riccia DN, Bizzini F, Perilli MG,Polimeni A, Trinchieri V, Amicosante G, et al. Anti-inflammatory effects of Lactobacillus brevis (CD2) on periodontal disease. Oral Dis 2007;13:376–85.)
Ebersole JL, Machen RL, Steffen ML, Willmann DE. Systemic acute phase reactants, C-reactive protein and haptoglobin, in adult periodontitis. Clin Exp. Immunol 1997; 107;347-352
Elter J, Williams R, Champagne C, Offenbacher S, Beck J. Association of obesity and periodontitis (abstract). J Dent Res. 2000, 79: 625.
Eleftherion P, Kynigopoulos S, Glovou A, Mazman,d, A, Yovos J, Skepastianos P, Vagdatli E, Petrou C, Ppara D, Papara D, Efterpiou M, Prevalance of Anti- Neu5Gc Antibodies in Patients with Hypothyroidism; Received 19 January 2014; Accepted 22 April 2014; Published 9 June 2014
Eriksson K, Studies on The Relatıonshıp Between Perıodontitis and Rheumatoid Aertritis Thesis for Doctoral Degree, Departmant Of Dental Medicine Karolinska Institutet, Stockholm, Swede 2017
Ernst E. Fibrinogen- an independent risk factor for cardiovascular disease. BMJ. 1991; 303: 596-7.
Farquharson D, Butcher JP, Culshaw S.,Periodontitis, Porphyromonas, and the pathogenesis of rheumatoid arthritis. Mucosal Immunol. 2012 Mar;5(2):112-20.
Fentoğlu Ö, Koçak H, Sütçü R, F. Kırzıoğlu Y, Periodontal Hastalıklı ve Hiperlipidemili Bireylerde Salya Malondialdehit, Süperokist Dismutaz, Glutatyon, ve Glutatyon Peroksidaz Seviyelerinin Değerlendirilmesi, SDÜ Sağlık Bilimleri Dergisi, Yıl 2010, Cilt 1, Sayı 2, Sayfalar 69 - 81
Galland L., Nutrition and Candidiasis, Journal of Orthomolecular Psychıatry, Volume 14, Number 1 p.50-60
Grossi S, Ho A. Obesity, insulin resistance and periodontal disease (Abstract). J Dent Res. 2000; 79: 625.
Guzman S, Karima M, Wang HY, Van Dyke TE, Association Between Interleukin‐1 Genotype and Periodontal Disease in a Diabetic Population, J Periodontol, Volume74, Issue8, August 2003, Pages 1183-1190
Hatakka K, Ahola AJ, Yli-Knuuttila H, Richardson M, Poussa T, Meurman JH, et al. Probiotics reduce the prevalence of oral Candida in the elderly--a randomized controlled trial. J Dent Res. 2007;86:125-30)
http://www.floradergisi.org/getFileContent.aspx?op=html&ref_id=64&file_name=1998-3-4-240-243.htm&_pk=46885eca-9418-47bd-86b5-e1ae95937cb4 (Jotwani ve ark., 2001 Jotwani R,
Leviatan Ben-Arye, S., Yu, H., Chen, X., Padler-Karavani, V. Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay . J. Vis. Exp. (125), e56094, doi:10.3791/56094 (2017).
Mayanagi G, Kimura M, Nakaya S, Hirata H, Sakamoto M, Benno Y, et al. Probiotic effects of orally administered Lactobacillus salivarius WB21-containing tablets on periodontopathic bacteria: a double-blinded, placebo-controlled, randomized clinical trial. J Clin Periodontol. 2009;36:506-13.)
Mealey BL., Periodontal disease and diabetes: A two-way Street, The Journal of the American Dental Association, Volume 137, Supplement 2, October 2006, Pages S26-S31
Mowat AM. Dendritic cells and immune responses to orally administered antigens. Vaccine 2005;23:1797–1799.)
Nesse W, Linde A, Abbas F, Karst F, Spijkervet L, Dijkstra PL, De Brabander EC, Ubele P, Gerstenbluth I, Vissink A, Dose–response relationship between periodontal inflamed surface area and HbA1c in type 2 Diabetics, Journal of Clinical Periodontology, Volume36, Issue4 April 2009 Pages 295-300
Özer Ö , Demiralp B., Periodontitis Kardiyovasküler Hastalığa Neden Olur mu? Atatürk Üniv. Diş Hek. Fak. 2005 ;15(2) :62-70
Özdemir EÇ, Gündoğar, Şenyurt SZ, Erciyas, Periodontal Hastalıklar, Turkiye Klinikleri J Dermatol-Special Topics 2015;8(4):24-8
Palucka AK, Al-Quotub M, Nouri-Shirazi M, Kim J, Bell D, et al. Mature dendritic cells infiltrate the T cell-rich oral mucosa in chronic periodontitis: in situ, in vivo and in vitro studies. J Immunol 2001;167:4693–4700. [PubMed: 11591800]).
Paşaoğlu ÖT, İnsan Umblikal Ven Endotel Hücre Kültürlerinde Endotoksin Aracılı Endotel Disfonksiyonda No-Adma-Homosistein Arasındaki İlişki, Arginin ve Taurinin Etkisi, Gazi Üniversitesi Sağlık Bilimleri Enstitüsü Tıbbi Biyokimya Anabilim Dalı Yüksek Lisans Tezi, Ankara, Ocak 2010
Pussinen PJ, Alfthan G, Tuomilehto, Asikainen S, Jousilahti P. High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction. Eur J Cardiovasc Prevand Rehabil 11: 408-411,2004.
Saito T, Shimazaki Y, Koga T, Tsuzuki M, Ohshima A. Relationship between upper body obesity and periodontitis.J Dent Res. 2001; 80: 1631-1636.
SAMRAJ, Annie N., et al. A red meat-derived glycan promotes inflammation and cancer progression. Proceedings of the National Academy of Sciences, 2015, 112.2: 542-547.
Shapira L, Ayalon S, Brenner T. Effects of Porphyromonas gingivalis on the central nervous system: activation of glial cells and exacerbation of experimental autoimmune encephalomyelitis. J Periodontol 2002; 73:511-516.
Shimauchi H, Mayanagi G, Nakaya S, Minamibuchi M, Ito Y, Yamaki K, et al. Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double- blind, placebo-controlled study. J Clin Periodontol. 2008;35:897-905.)
Syrjanen J. Vascular diseases and oral infections. J Clin Periodontol. 1990; 17: 497-500.
Taneja V, David C S. Porphyromonas Gingivalis and Rheumatoid Arthritis, The Autoimmune Diseases (Fifth Edition), 2014
Twetman S, Derawi B, Keller M, Ekstrand K, Yucel-Lindberg T, Stecksen-Blicks C. Short-term effect of chewing gums on the levels of inflammatory mediators in gingival crevicular fluid. Acta Odontol Scand 2009;67:1)
Topkaya A E , Güneş H, Bakterilerde Epigenetik, Int J Basic Clin Med 2013;1(1): 67-73
Upham Upham JW, Stumbles PA. Why are dendritic cells important in allergic diseases of the respiratory tract. Pharmacol Ther 2003;100:75–87.)
Williamson ve ark, 2002; Williamson E, Bilsborough JM, Viney JL. Regulation of mucosal dendritic cell function by receptor activator of NF-kappaB (RANK)/RANK ligand interactions: impact on tolerance induction. J Immunol 2002;169:3606–3612.
Wood N, Johnson RB, Streckfus CF. Comparison of body composition and periodontal disease using nutritional assessment techniques: Third National Health and Nutrition Examination Survey (NHANES III). J Clin Periodontol. 2003; 30: 321–327.
Wu T, Trevisan M, Genco RJ, Falkner KL, Dorn JP, Sempos CT. Examination of the relation between periodontal health status and cardiovascular risk factors: serum total and high density lipoprotein cholesterol, C-reactive protein, and plasma fibrinogen. Am J Epidemiol. 2000; 151: 273-82.
Yudkin YS, Stehouwer CDA, Emeis JJ, Coppack SW. C-reactive protein in healty subjects: Associations with obesity, insulin resistance, and endothelial dysfunction. A potential role for cytokines originating from adipose tissue? Arterioscler Thromb Vasc Biol 1999; 19;972-978
Xu Q, Wick G. The role of heat shock proteins in protection and pathophysiology of the arterial wall. Mol Med Today 1996; 2 (9); 372-3
(Jotwani ve ark., 2001 Jotwani R, Palucka AK, Al-Quotub M, Nouri-Shirazi M, Kim J, Bell D, et al. Mature dendritic cells infiltrate the T cell-rich oral mucosa in chronic periodontitis: in situ, in vivo and in vitro studies. J Immunol 2001;167:4693–4700. [PubMed: 11591800]).
Aydın M. Dentalife dergisi Sayı:14 Şubat-2005 sayfa:26.
Berne RM. Physiology. 4th ed. St Louis (MO): Mosby, 1998;619-21.
Carlson GW. The salivary glands. Embryology, anatomy, and surgical applications. Surg Clin North Am 2000;80:261-73.
Burton JP, Chilcott CN, Tagg JR. The Rationale And Potential For The Reduction Of Oral Malodour Using Streptococcus Salivarius Probiotics. Oral Dis 2005;11 Suppl 1:29-31.
Cummings JH, Pomare EW, Branch WJ, Naylor CP, Macfarlane GT. Short Chain Fatty Acids in Human Large Intestine, Portal, Hepatic and Venous Blood. Gut 1987; 28: 1221-7.
Cummings JH, Beaty ER, Kingman SM, Bingham SA, Englyst HN. Digestion And Physiological Properties Of Resistant Starch In The Human Barge bowel. Br J Nutr 1996; 75 : 733-47.
Curd ML, Bollen, Beikler T. Halitosis: The Multidisciplinary Approach International Journal of Oral Science (2012) 4, 55–63
Çetin A. R., Karabekoroğlu S., Ünlü N.,Probiyotikler ve Ağız Sağlığına Etkileri, Süleyman Demirel Üniv Diş Hek Fak Derg. Cilt/Vol.:3 Sayı/No.:1 Sayfa/Page:19-29, 2011
Henker J, Schuster F, Nissler K.Successful Treatment Of Gut-Caused Halitosis With A Suspension Of Living Nonpathogenic Escherichia Coli Bacteria-Acase Report. Eur J Pediatr 2001;160: 592-94.
Hyink O, Wescombe PA, Upton M, Ragland N, Burton JP, Tagg JR. Salivaricin A2 And The Novel Santibiotic Salivaricin B Are Encoded At Adjacent Loci On a 190-kilobase Transmissible Megaplasmid In The Oral Probiotic Strain Streptococcus Salivarius K12. Appl Environ Microbiol. 2007; 73:
Iwamoto T, Suzuki N, Tanabe K, Takeshita T, Hirofuji T. Effects of Probiotic Lactobacillus Salivarius WB21 on Halitosis and Oral Health: An Open-Label Pilot Trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;110:201-8
Karakan M, Tamam Y, Gültekin S, Erturhan S, Elmacıoğlu M.A, Nazlıkul H. Kronik bel ağrılarında nöralterapi uygulamalarının etkinliği. Barnat, 2016:10:3:5-10
Koçak H, Timoçin N, Öz F, Uraz S, Gömük Alt Akıl Dişi Çevre Dokularının Histopatolojik ve İmmunohistokimyasal Değerlendirilmesi, İÜ Diş Hekimliği Fakültesi Dergisi 1994;28:83-86
Kang MS, Kim BG, Chung J, Lee HC, Oh JS. Inhibitory Effect of Weissella cibaria Isolates On The Production Of Volatile Sulphur Compounds. J Clin Periodontol. 2006;33:226-32.
Keçeci AD, Özdemir F; Ağız Kuruluğu ve Tedavisi, S.D.Ü. Tıp Fak. Derg. 2005:12(4)/ 58-67
Matsuoka T, Sugano N, Tanigawa S, Takane M, Yoshimura N, Ito K, et al. Effect of Oral Lactobacillus Salivarius TI 2711 (LS1) Administration on Periodontopathic Bacteria in Subgingival Plaque. J Jpn Soc Periodontol. 2006;48:315-24.
Nazlıkul H, Nöralterapi ve tamamlayıcı tıp yaklaşımı ile bozucu alan veya bozucu odak olarak diş. Barnat. 2012; 15, 12-17
Nazlıkul H. Çoklu bozucu alan kaynaklı servikal-omuz sendromu. Barnat, 2015:9:3,1-4
Özen T, Karakurumer K, Şengün O, Günaydın Y, Üstün T, Türk toplumunda gömülü diş sıklığının araştırılması, G.Ü. Diş hek. Fak. Der. Cilt 9, Sayı 2, Sayfa 121-134. 1992
Persson S, Edlund MB, Claesson R, Carlsson J. The formation of hydrogen sulfide and methyl mercaptan by oral bacteria. Oral microbiology and immunology. 1990;5:195–201
Secerli Dürer T, Karakan M, Nazlıkul H. Gömük Kanin ve Molar Diş Kaynaklı Kronik Ağrıda Nöralterapi. Bilimsel Tamamlayıcı Tıp, Regülasyon ve Nöralterapi Dergisi 2017 ,Cilt 11, Sayı 2 : S:22-26
Taşdoğan B. E., Gümürdülü Y. Halitozis ve Helikobakter Pilori Güncel Gastoenteroloji 15/3
Tseng WS; Halitosis: could it be a predictor of stroke? Med Hypotheses. 2014 Mar;82(3):335-7.
