Acil Pediatrik Nöroşirurjide Anestezi Yönetimi
Özet
Acil pediatrik nöroşirürji vakalarında anestezi yönetimi, çocukların yetişkinlerden farklı olan anatomik, fizyolojik ve metabolik özelliklerinin derinlemesine anlaşılmasını gerektirir. Çocuklarda serebral kan akımı (SKA) ve oksijen metabolizması yaşla birlikte hızla değişir; bu süreç PaCO2 seviyelerine son derece duyarlıdır. İntrakraniyal basınç (İKB) yönetimi cerrahinin temelidir; Monro-Kellie doktrini çerçevesinde kafa içi hacim dengesinin korunması hayati önem taşır. Preoperatif değerlendirmede kapsamlı bir öykü, Glasgow Koma Skalası ile bilinç durumu takibi ve laboratuvar tetkikleri gereklidir. İndüksiyon sırasında İKB artışını ve aspirasyon riskini önlemek için propofol veya tiyopental gibi ajanlar tercih edilirken, ketaminden genellikle kaçınılır. Havayolu yönetiminde çocukların dar nazal pasajları ve yüksek larenks yapıları göz önünde bulundurulmalı, tüp tespiti titizlikle yapılmalıdır. Operasyon sırasında invaziv monitörizasyon, vücut ısısı regülasyonu ve venöz hava embolisi takibi kritik öneme sahiptir. Sıvı tedavisinde normovolemiyi korumak için genellikle izotonik salin tercih edilirken, İKB'yi düşürmek için mannitol veya hipertonik salin kullanılabilir. Derlenme aşamasında ise hastanın nörolojik muayenesine izin verecek şekilde kontrollü bir ekstübasyon hedeflenir.
Anesthesia management in emergency pediatric neurosurgery requires a profound understanding of children's unique anatomical, physiological, and metabolic characteristics, which differ significantly from adults. Cerebral blood flow (CBF) and oxygen metabolism in children change rapidly with age and are highly sensitive to PaCO2 levels. Intracranial pressure (ICP) management is the cornerstone of surgery; maintaining the intracranial volume balance within the framework of the Monro-Kellie doctrine is vital. Preoperative evaluation necessitates a comprehensive history, monitoring of consciousness via the Glasgow Coma Scale, and laboratory tests. During induction, agents like propofol or thiopental are preferred to prevent ICP increases and aspiration risks, while ketamine is generally avoided. In airway management, children's narrow nasal passages and superior laryngeal positions must be considered, with meticulous tube fixation. Intraoperative invasive monitoring, body temperature regulation, and vigilance for venous air embolism are critical. For fluid therapy, isotonic saline is typically preferred to maintain normovolemia, while mannitol or hypertonic saline may be used to reduce ICP. The recovery phase aims for a controlled extubation that allows for an immediate postoperative neurological examination.
Referanslar
McClain CD, Soriano SG. Principles of paediatric neurosurgery. In: Matta BF, Menon DK, Smith M (eds.) Core topics in neuroanaesthesia and neurointensive care (205-222). New York: Cambridge University Press; 2011.
Liu P, Huang H, Rollins N, et al. Quantitative assessment of global cerebral metabolic rate of oxygen (CMRO2) in neonates using MRI. NMR in biomedicine. 2014;27(3): 332-340. doi:10.1002/nbm.3067
Kety SS, Schmidt CF. The effects of altered arterial tensions of carbon dioxide and oxygen on cerebral blood flow and cerebral oxygen consumption in normal young men. The Journal of Clinical Investigation. 1948; 27:484–492. doi:10.1172/JCI101995
Schmetterer L, Findl O, Strenn K,et al. Role of NO in the O2 and CO2 responsiveness of cerebral and ocular circulation in humans. The American Journal of Physiology. 1997;273(6): R2005-2012.
Pryds O. Control of cerebral circulation in the high-risk neonate. Annals of Neurology. 1991;30: 321-329. 6.
Vavilala MS, Bowen A, Lam AM, et al. Blood pressure and outcome after severe pediatric traumatic brain injury. The Journal of Trauma. 2003;55(6):1039-1044.
Rath GP, Dash HH. Anaesthesia for neurosurgical procedures in paediatric patients. Indian Journal of Anaesthesia. 2012;56(5): 502-510. doi:10.4103/0019-5049.103979.
Vavilala MS, Newell DW, Junger E, et al. Dynamic cerebral outoregulation in healthy adolescents. Acta Anaesthesiologica Scandinavica. 2002;46(4): 393-397.
Arieff AI, Ayus JC, Fraser CL. Hyponatraemia and death or permanent brain damage in healthy children. BMJ: British medical journal / British Medical Association. 1992;304(6836): 1218-1222. doi:10.1136/bmj.304.6836.1218.
Krane EJ, Phillip BM, Yeh KK, Domino KB. Anaesthesia for paediatric neurosurgery. In: Smith RM, Mototyama EK, Davis PJ, editors. Smith’s Anaesthesia for Infants and Children (651-684). 7th Edn. Philadelphia: Mosby Press; 2005.
Cohen MM, Cameron CB, Duncan PG. Pediatric anesthesia morbidity and mortality in the perioperative period. Anesthesia and Analgesia. 1990;70: 160-167.
Holzman RS. Clinical management of latex-allergic children. Anesthesia and Analgesia. 1997;85(3):529-533. doi:10.1097/00000539-199709000-00009.
Türk Anesteziyoloji ve Reanimasyon Derneği. Anestezi uygulama kılavuzları: Preoperatif hazırlık. (22.08.2021 tarihinde https://tard.org.tr/assets/kilavuz/3.pdf adresinden ulaşılmıştır).
Mitchell MC, Farid I. Anesthesia for Common Pediatric Emergency Surgeries.The Surgical Clinics of North America. 2017;97(1): 223-232. doi:10.1016/j.suc.2016.08.014.
Ghazal EA, Mason LJ, Cote CJ. Preoperative evaluation, premedication and induction of anesthesia In: Cote CJ, Lerman J, Anderson BJ (Ed.), A practice of anesthesia for infants and children Anesthesia for infants and children (31-63). 8th Edn. Philadelphia, Elsevier Press; 2009.
Reilly PL, Simpson DA, Sprod R, et al. Assessing the conscious level in infants and young children: A paediatric version of the Glasgow Coma Scale. Child's nervous system: ChNS: Official Journal of The International Society for Pediatric Neurosurgery. 1988;4 (1): 30-33. doi:10.1007/BF00274080.
Tatman A, Warren A, Williams A, et al. Development of a modified paediatric coma scale in intensive care clinical practice. Archives of Disease in Childhood. 1997;77(6): 519-521. doi:10.1136/adc.77.6.519.
Bissonnette B, Brady K, Easley R. Anesthesia for Neurosurgical Procedures. In: Gregory G, Andropoulos D. (Ed.),Gregory’s Pediatric Anesthesia (540-569). 5th Edn. USA: Blackwell Pres; 2012.
McCann ME, Kain ZN. Management of perioperative anxiety in children. Anesthesia and Analgesia. 2001;93(1): 98-105. doi:10.1097/00000539-200107000-00022.
Wang J, McClain C. Pediatric Neuroanesthesia. In: Hemanshu Prabhakar, Zul¬fiqar Ali (Ed.) Textbook of Neuroanesthesia and Neurocritical Care (291-311). India: Springer Press; 2019.
Soriano SG, Rockoff MA. Neuroanesthesia in children. In: Winn HR (Ed.),Youman’s neurosurgical surgery (1861-1870). 6th Edn. Philadelphia: Elsevier Saunders; 2011.
Shapiro HM, Galindo A, Wyte SR, Harris AB. Rapid intraoperative reduction of intracranial pressure with thiopentone. British Journal of Anaesthesia. 1973;45: 1057–1062.
Abou-Madi MN, Keszler H, Yacoub JM. Cardiovascular reactions to laryngoscopy and tracheal intubation following small and largeintravenous doses of lidocaine. Canadian Anaesthetists' Society Journal. 1977;24(1): 12-19. doi:10.1007/BF03006808.
Aylward SC, Reem RE. Pediatric Intracranial Hypertension. Pediatric Neurology. 2017;66: 32-43. doi:10.1016/j.pediatrneurol.2016.08.010.
Lockhart CH, Jenkins JJ. Ketamine-induced apnea in patients with increased intracranial pressure. Anesthesiology. 1972;37(1): 92-93. doi:10.1097/00000542-197207000-00020.
Tempelhoff R. The new inhalational anesthetics desflurane and sevoflurane are valuable additions to the practice of neuroanesthesia: con. Journal of Neurosurgical Anesthesiology. 1997;9(1): 69-71. doi:10.1097/00008506-199701000-00016.
Mazurek AJ, Rae B, Hann S, et al. Rocuronium versus succinylcholine: are they equally effective during rapid-sequence induction of anesthesia? Anesthesia and Analgesia. 1998;87(6): 1259-1262. doi:10.1097/00000539-199812000-00009.
Von Ungern-Sternberg BS, Habre W. Pediatric anesthesia - potential risks and their assessment: part I. Paediatric Anaesthesia. 2007;17(3): 206–215.
Weiss M, Gerber A. Cuffed tracheal tubes in children-things have changed. Paediatric Anaesthesia. 2006;16(10): 1005-1007. doi:10.1111/j.1460-9592.2006.02071.x.
Kalita N, Goswami A, Goswami P. Review Article Making Pediatric Neuroanesthesia. Journal of Pediatric Neurosciences. 2017;12(4): 305-312.
Faberowski LW, Black S, Mickle JP. Incidence of venous air embolism during craniectomy for craniosynostosis repair. Anesthesiology. 2000;92: 20-23. doi:10.1097/00000542-200001000-00009.
Adelson PD, Bratton SL, Carney NA et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Pediatric Critical Care Medicine. 2012;13 Suppl 1: S1-82. doi:10.1097/PCC.0b013e31823f435c.
Craig D McClain , Sulpicio G Soriano. Anesthesia for intracranial surgery in infants and children. Current Opinion İn Anaesthesiology. 2014;27(5): 465-469. doi:10.1097/ACO.0000000000000112.
Sumpelman R, Becke K, Brenner S, et al. Perioperative intravenous fluid therapy in children: guidelines from the Association of the scientifik Medical Societies in Germany. Peaediatric Anaesthesia. 2017;27(1): 10-18. doi:10.1111/pan.13007.
Sümpelmann R, Becke K, Zander R, Witt L. Perioperative fluid management in children: can we sum it all up now? Current Opinion in Anaesthesiology. 2019;32(3): 384-391. doi:10.1097/ACO.0000000000000727.
Heimann K, Peschgens T, Kwiecien R, et al. Are recurrent hyperglycemic episodes and median blood glucose level a prognostic factor for increased morbidity and mortality in premature infants ≤1500g? Journal of Perinatal Medicine. 2007;35: 45–48. doi:10.1515/JPM.2007.057.
Sterns RH, Silver SM. Complications and management of hyponatremia. Current Opinion in Nephrology and Hypertension. 2016;25: 114-119. doi:10.1097/MNH.0000000000000200.
Choong K, Kho ME, Menon K, et al. Hypotonic versus isotonic saline in hospitalised children: a systematic review. Archives of Disease in Childhood. 2006;91(10): 828-835. doi:10.1136/adc.2005.088690.
McCluskey SA, Karkouti K, Wijeysundera D, et al. Hyperchloremia after noncardiac surgery is independently associated with increased morbidity and mortality: a propensity-matched cohort study. Anesthesia Analgesia. 2013;117: 412–421. doi:10.1213/ANE.0b013e318293d81e.
Neville KA, Sandeman DJ, Rubinstein A, et al. Prevention of hyponatremia during maintenance intravenous fluid administration: a prospective randomized study of fluid type versus fluid rate. The Journal of Pediatrics. 2010; 156: 313-319. doi:10.1016/j.jpeds.2009.07.059.
Goobie SM, Haas T. Bleeding management for pediatric craniotomies and craniofacial surgery. Pediatric Anesthesia. 2014; 24: 678–689. doi:10.1111/pan.12416.
Doyle J, Davis D, Hoyt D. The use of hypertonic saline in the treatment of traumatic brain injury. The Journal of Trauma. 2001;2: 367–383. doi:10.1097/00005373-200102000-00030.
Sorani MD, Manley GT. Dose-response relationship of Mannitol and intracranial pressure: a metaanlysis. Journal of Neurosurgery. 2008;108: 80-87. doi:10.3171/JNS/2008/108/01/0080.
Castillo LR, Robertson CS. Management of intracranial hypertension. Critical Care Clinics. 2007;22: 713-732. doi:10.1016/j.ncl.2008.02.003.
Menkes JH, Sarnat HB, Sarnat LF. Malformations of the central nervous system. In: John HM (Ed.), Paediatric neurology (285-366). London, Lippincott: Williams Wilkins; 2006.
Singh D, Rath GP, Dash HH, et al. Sevoflurane provides better recovery as compared with isoflurane in children undergoing spinal surgery. Journal of Neurosurgical Anesthesiology. 2009;21: 202–206. doi:10.1097/ANA.0b013e31819f1ce0.
Chu L, Fuller A. Manual of clinical anesthesiology. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2012.
Dağoğlu T. Prematürite. ‘içinde’ Dağoğlu T, Ovalı F (Ed.), Neonatoloji (221-228) İstanbul: Nobel Tıp Kitabevleri, 2007.
Khodapanahandeh F, Khosravi N, Larijani T. Risk factors for intraventricular hemorrhage in very low birth weight infants in Tehran, Iran. The Turkish Journal of Pediatrics. 2008;50: 247-252.
Adams-Chapman I, Hansen NI, Stoll BJ, et al. Neurodevelopmental outcome of extremely low birth weight infants with posthemorrhagic hydrocephalus requiring shunt insertion. Pediatrics. 2008;121: e1167–1177. doi:10.1542/peds.2007-0423.
Hacıyakupoğlu E, Oktay K, Olguner KS, ve ark. Çocukluk Çağı Beyin Tümörleri. Arşiv Kaynak Tarama Dergisi. 2014;23: 367-386. doi:10.17827/aktd.15184.
Biricik E, Güneş Y. Pediyatrik nöroanestezi. Türk Anesteziyoloji ve Reanimasyon Derneği, Nöroanestezi rehberi. (22.08.2021 tarihinde http://www.tard.org.tr/akademi/?p=detail&bID=7&capt=3&sub=12&session=13615951799034-27231903598068, adresinden ulaşılmıştır).
Huh J, Raghupathi R. New concepts in treatment of pediatric traumatic brain injury. Anesthesiology Clinics. 2009;27(2): 213-240. doi:10.1016/j.anclin.2009.05.006.
Tobias JD. Etomidate: applications in pediatric critical care and pediatric anesthesiology. Pediatric Critical Care Medicine. 2000;1: 100–106. doi:10.1097/00130478-200010000-00002.
Bar-Joseph G, Guilburd Y, Tamir A. et al. Effectiveness of ketamine in decreasingintracranial pressure in children with intra-cranial hypertension. Journal of Neurosurgery. Pediatrics. 2009;4: 40–46. doi:10.3171/2009.1.PEDS08319.
Tobias JD. Airway management for pediatric emergencies. Pediatric Annals. 1996;25(6): 317-320, 323-328. doi:10.3928/0090-4481-19960601-07.
Tran DT, Newton EK, Mount VA, et al. Rocuronium versus succinylcholine for rapid sequence induction intubation. The Cochrane Database of Systematic Reviews. 2015;2015(10): CD002788. doi:10.1002/14651858.CD002788.pub3.
Adelson PD, Bratton SL, Carney NA, et al. Guidelines for the acute medical management of severe traumatic brain injury ininfants, children, and adolescents. Chapter 10. The role of cerebrospinal fluid drainage in the treatment of severe pediatric traumatic brain injury. Pediatric Critical Care Medicine. 2003;4(3 Suppl): S38-39.
Adelson PD, Bratton SL, Carney NA, et al. Guidelines for the acute medical management of severe traumatic brain injury in infants, children, and adolescents. Chapter 12. Use of hyperventilation in the acutemanagement of severe pediatric traumaticbrain injury. Pediatric Critical Care Medicine. 2003;4: S45–S48.
Cooper DJ, Myles PS, McDermott FT, et al. Prehospital hypertonic saline resuscitationof patients with hypotension and severetraumatic brain injury: a randomized controlled trial.Journal of the American Medical Association. 2004;291: 1350–1357. doi:10.1001/jama.291.11.1350.
Edwards P, Arango M, Balica L, et al. Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury outcomesat 6 months. Lancet. 2005;365: 1957–1959. doi:10.1016/S0140-6736(05)66552-X.
Liesemer K, Bratton SL, Zebrack CM, et al. Early post-traumatic seizures in moderate tosevere pediatric traumatic brain injury: rates, risk factors, and clinical features. Journal of Neurotrauma. 2011;28: 755–762. doi:10.1089/neu.2010.1518.
Hardcastle N, Benzon Ha, Vavilala Ms. Update on the 2012 guidelines for the management of pediatric traumatic brain injury – information for the anesthesiologist. Pediatric Anesthesia. 2014;24: 703–710. doi:10.1111/pan.12415.