Kanserli Çocuk ve Ergenlerde Görülen Uyum Sorunları, Yaşam Kalitesi ve Psikiyatrik Bozukluklar
Özet
Kanser, çocuklarda yetişkinlere kıyasla daha az görülse de her yıl dünyada binlerce çocuk ve ergen bu tanıyı almaktadır; günümüzde gelişen teknolojiyle yüksek gelirli ülkelerde sağ kalım oranları yüzde 80'e kadar çıkmıştır. İyileşme oranlarının artmasıyla birlikte, kanserin ve tedavi sürecinin çocuk ile ailesi üzerindeki fiziksel, psikolojik ve sosyal etkileri ile yaşam kalitesi ön plana çıkmıştır. Sık hastaneye yatışlar, cerrahi ve radyoterapi gibi ağır tedaviler ile akranlardan izolasyon, çocuklarda uyum sorunlarına yol açarak anksiyete, depresyon, uyum bozuklukları ve travma sonrası stres bozukluğu riskini belirgin şekilde artırmaktadır. Özellikle sinir sistemini etkileyen tümörler ve ALL gibi tedaviler çocuklarda öğrenme güçlüğü, kısa dikkat süresi gibi nörokognitif bozulmalara sebebiyet verebilmektedir. Bu zorlu süreç ebeveynleri de derinden etkilemekte, tanı sonrasındaki ilk yılda ebeveynlerin yarısından fazlasında yüksek psikolojik stres ve akut stres bozukluğu semptomları görülmektedir. Kanseri atlatan sağ kalanların büyük kısmı psikolojik olarak sağlıklı olsa da, yoğun tedavilerin getirdiği sekeller nedeniyle anksiyete ve somatik kaygılara yatkın bir alt grup bulunmaktadır; bu yüzden hem tedavi esnasında hem de sağ kalım sonrasında düzenli psikososyal değerlendirmeler ve erken müdahaleler hayati önem taşımaktadır.
Although cancer is less common in children compared to adults, thousands of children and adolescents are diagnosed worldwide each year; today, with advancing technology, survival rates have risen up to 80% in high-income countries. As recovery rates increase, the physical, psychological, and social effects of cancer and its treatment process on the child and family, along with their quality of life, have come to the fore. Factors such as frequent hospitalizations, heavy treatments like surgery and radiotherapy, and isolation from peers cause adjustment problems in children, significantly increasing the risk of anxiety, depression, adjustment disorders, and post-traumatic stress disorder. Particularly, tumors affecting the nervous system and treatments like ALL can cause neurocognitive impairments in children, such as learning difficulties and short attention spans. This challenging process also deeply affects parents, with more than half of them experiencing high psychological distress and acute stress disorder symptoms in the first year following diagnosis. Although the majority of cancer survivors are psychologically healthy, there is a subgroup susceptible to anxiety and somatic concerns due to sequelae from intensive treatments; therefore, regular psychosocial assessments and early interventions both during treatment and post-survival are of vital importance.
Referanslar
Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal For Clinicians. 2021;71(3):209-49.
Lam CG, Howard SC, Bouffet E, et al. Science and health for all children with cancer. Science. 2019;363(6432):1182-6.
Şencan, İ. and Keskinkılıç B. "Türkiye kanser istatistikleri." TC Sağlık Bakanlığı Türkiye Halk Sağlığı Kurumu (2017).
Sites A, SEER Cancer Statistics Review 1975–2011. Bethesda, MD: National Cancer Institute,2014 (10.11.2021 tarihinde https://seer.cancer.gov/archive/csr/1975_2011 adresinden ulaşılmıştır.)
Steele AC, Mullins LL, Mullins AJ, et al.. Psychosocial Interventions and Therapeutic Support as a Standard of Care in Pediatric Oncology. Pediatric Blood & Cancer. 2015;62 (5),S585-618.
Barrera M, Hancock K, Rokeach A, et al. External validity and reliability of the Psychosocial Assessment Tool (PAT) among Canadian parents of children newly diagnosed with cancer. Pediatric Blood & Cancer. 2014;61(1):165-70.
Calaminus G, Kiebert G. Studies on health‐related quality of life in childhood cancer in the European setting: An overview. International Journal of Cancer. 1999;83(S12):83-6.
Salley CG, Gerhardt CA, Fairclough DL, ,et al. Social self-perception among pediatric brain tumor survivors compared to peers. Journal of Development and Behavioral Pediatrics: JDBP. 2014;35(7):427.
Myers RM, Balsamo L, Lu X, et al. A prospective study of anxiety, depression, and behavioral changes in the first year after a diagnosis of childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group. Cancer. 2014;120(9):1417-25.
Gerhardt CA, Yopp JM, Leininger L, et al. Brief report: post-traumatic stress during emerging adulthood in survivors of pediatric cancer. Journal of Pediatric Psychology. 2007;32(8):1018-23.
Kazak AE, Alderfer MA, Streisand R, et al. Treatment of posttraumatic stress symptoms in adolescent survivors of childhood cancer and their families: a randomized clinical trial. Journal of Family Psychology. 2004;18(3):493.
Fuemmeler BF, Elkin TD, Mullins LL. Survivors of childhood brain tumors: behavioral, emotional, and social adjustment. Clinical Psychology Review. 2002;22(4):547-85.
Lown EA, Phillips F, Schwartz LA, et al. Psychosocial follow‐up in survivorship as a standard of care in pediatric oncology. Pediatric Blood & Cancer. 2015;62(S5):S514-S84.
Masa’Deh R, Collier J, Hall C, Alhalaiqa F. Predictors of stress of parents of a child with cancer: a Jordanian perspective. Pediatric Blood & Cancer. 2013;5(6):81.
Sloper P. Predictors of distress in parents of children with cancer: a prospective study. Journal of Pediatric Psychology. 2000;25(2):79-91.
Patiño-Fernández AM, Pai AL, Alderfer M, et al. Acute stress in parents of children newly diagnosed with cancer. Pediatric Blood & Cancer. 2008;50(2):289-92.
Pai AL, Greenley RN, Lewandowski A, et al. A meta-analytic review of the influence of pediatric cancer on parent and family functioning. Journal of Family Psychology. 2007;21(3):407-15.
Kim S. World Health Organization Quality of Life (WHOQOL) Assessment. Encyclopedia of Quality of Life and Well-Being Research. 2020; 1-2
Pan HT, Wu LM, Wen SH. Quality of Life and Its Predictors Among Children and Adolescents With Cancer. Cancer Nursing. 2017;40(5):343-51.
Tomatis L. Poverty and cancer. IARC Scientific Publications. 1997(138):25-39.
Bibace R, Walsh ME. Development of children's concepts of illness. Pediatrics. 1980;66(6):912-7.
Eiser C, Morse R. Quality-of-life measures in chronic diseases of childhood. Health Technol Assess. 2001;5(4):1-157.
APA (2013). American Psychiatric Association (US). Diagnostic ans Statistical Manual of Mental Disorders. Fifth Edition. Washington: American Psychiatric Association,2013.
Datta SS, Cardona L, Mahanta P, et al. Pediatric Psycho-Oncology. 2019.
Whitsett SF, Gudmundsdottir M, Davies B, et al. Chemotherapy-Related Fatigue in Childhood Cancer: Correlates, Consequences, and Coping Strategies. Journal of Pediatric Oncology Nursing. 2008;25(2):86-96.
Chao CC, Chen SH, Wang CY, et al. Psychosocial adjustment among pediatric cancer patients and their parents. Psychiatry and Clinical Neurosciences. 2003;57(1):75-81.
Goldman A, Hewitt M, Collins GS, et al. Symptoms in children/young people with progressive malignant disease: United Kingdom Children's Cancer Study Group/Paediatric Oncology Nurses Forum survey. Pediatrics. 2006;117(6):e1179-86.
Valente SM, Saunders JM. Diagnosis and treatment of major depression among people with cancer. Cancer Nursing. 1997;20(3):168-77.
Ahomäki R, Gunn ME, Madanat-Harjuoja LM, et al. Late psychiatric morbidity in survivors of cancer at a young age: a nationwide registry-based study. International Journal of Cancer. 2015;137(1):183-92.
Lewis DR, Seibel NL, Smith AW, et al. Adolescent and young adult cancer survival. Journal of the National Cancer Institute Monographs. 2014;2014(49):228-35.
Zeltzer LK, Recklitis C, Buchbinder D, et al. Psychological status in childhood cancer survivors: a report from the Childhood Cancer Survivor Study. Journal of Clinical Oncology. 2009;27(14):2396.
Matziou V, Perdikaris P, Galanis P, et al. Evaluating depression in a sample of children and adolescents with cancer in Greece. International Nursing Review. 2008;55(3):314-9.
Spitz RA. Hospitalism; an inquiry into the genesis of psychiatric conditions in early childhood. The Psychoanalytic Study of the Child. 1945;1:53-74.
Brown RF, Bylund CL, Kline N, et al. Identifying and responding to depression in adult cancer patients: evaluating the efficacy of a pilot communication skills training program for oncology nurses. Cancer Nursing. 2009;32(3):E1-E7.
Montazeri N, Kianipour N, Nazari B,et al. Health promoting behaviors among university students: a case-sectional study of Kermanshah University of Medical Sciences. International Journal of Pediatrics. 2017;5(6):5091-9.
Reiche EMV, Nunes SOV, Morimoto HKJ. Stress, depression, the immune system, and cancer. The Lancet Oncology. 2004;5(10):617-25.
Nazari B, Bakhshi S, Kaboudi M, et al. A comparison of quality of life, anxiety and depression in children with cancer and healthy children, Kermanshah-Iran. International Journal of Pediatrics. 2017;5(7):5305-14.
Pelcovitz D, Libov BG, Mandel F,et al. Posttraumatic stress disorder and family functioning in adolescent cancer. Journal of Traumatic Stress Official Publication of The International Society for Traumatic Stress Studies. 1998;11(2):205-21.
Butler RW, Rizzi LP, Handwerger BA. Brief report: the assessment of posttraumatic stress disorder in pediatric cancer patients and survivors. Journal of Pediatric Psychology. 1996;21(4):499-504.
Phipps S, Klosky JL, Long A, et al. Posttraumatic stress and psychological growth in children with cancer: has the traumatic impact of cancer been overestimated? Journal of Clinical. 2014;32(7):641.
Yaskowich KM. Posttraumatic growth in children and adolescents with cancer.2003. PhD Thesis. ProQuest Information & Learning.
Linley PA, Joseph S. Positive change following trauma and adversity: a review. J Trauma Stress. Journal of Traumatic Stress Official Publication of The International Society for Traumatic Stress Studies 2004;17(1):11-21.
Campbell LK, Scaduto M, Sharp W, et al. A meta‐analysis of the neurocognitive sequelae of treatment for childhood acute lymphocytic leukemia. Pediatric Blood & Cancer. 2007;49(1):65-73.
Robinson KE, Kuttesch JF, Champion JE, et al. A quantitative meta‐analysis of neurocognitive sequelae in survivors of pediatric brain tumors. Pediatric Blood & Cancer 2010;55(3):525-31.
Nathan PC, Patel SK, Dilley K, et al. Guidelines for identification of, advocacy for, and intervention in neurocognitive problems in survivors of childhood cancer: a report from the Children's Oncology Group. Archives of Pediatrics & Adolescent Medicine. 2007;161(8):798-806.
Phipps S, Dunavant M, Srivastava DK, et al. Cognitive and academic functioning in survivors of pediatric bone marrow transplantation. Journal of Clinical Oncology. 2000;18(5):1004-11.
Apter A, Farbstein I, Yaniv I, Psychiatric aspects of pediatric cancer. Child and Adolescent Psychiatric Clinics. 2003;12(3):473-92.
Barakat LP, Kazak AE, Meadows AT, et al. Families surviving childhood cancer: a comparison of posttraumatic stress symptoms with families of healthy children. Journal of Pediatric Psychology. 1997;22(6):843-59.
Madan-Swain A, Brown R.T. Cognitive and Psychosocial Sequelae for Children with Acute Lymphocytic Leukemia and Their Families. Clinical Psychology Rewiew. 1991;11:267-94.
Kupst MJ, Natta MB, Richardson CC, et al. Family coping with pediatric leukemia: ten years after treatment. Journal of Pediatric Psychololgy. 1995;20(5):601-17.
Wenninger K, Helmes A, Bengel J, et al. Coping in long-term survivors of childhood cancer: relations to psychological distress. Psychooncology. 2013;22(4):854-61.
Schultz KA, Ness KK, Whitton J, et al. Behavioral and social outcomes in adolescent survivors of childhood cancer: a report from the childhood cancer survivor study. Journal of Clinical Oncology. 2007;25(24):3649-56.
Stuber ML, Meeske KA, Krull KR, et al. Prevalence and predictors of posttraumatic stress disorder in adult survivors of childhood cancer. Pediatrics. 2010;125(5):e1124-34.
Chen E, Zeltzer LK, Bentler PM, et al. Pathways Linking Treatment Intensity and Psychosocial Outcomes among Adult Survivors of Childhood Leukemia. Journal of Health Psychology. 1998;3(1):23-38.
Mitby PA, Robison LL, Whitton JA, et al. Utilization of special education services and educational attainment among long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study. Cancer: Interdisciplinary. International Journal of the American Cancer Society 2003;97(4):1115-26.