Akut Apandisit
Özet
Akut apandisit, apendiks lümeninin obstrüksiyonu sonucu gelişen ve günümüzde en sık uygulanan acil cerrahi operasyonların başında gelen bir klinik tablodur. Genellikle yaşamın ikinci ve üçüncü dekatında görülen bu hastalık, periumblikal bölgede başlayıp sağ alt kadrana lokalize olan karın ağrısı, iştahsızlık, bulantı ve kusma gibi tipik semptomlarla kendini gösterir. Tanı sürecinde anamnez ve fizik muayene bulguları (McBurney hassasiyeti, rebound, Rovsing bulgusu) temel taşı teşkil ederken, tanıyı desteklemek amacıyla lökositoz ve CRP takibi ile birlikte USG, BT veya MRG gibi görüntüleme yöntemlerinden faydalanılır. Tedavide altın standart, özellikle laparoskopik yöntemin sunduğu daha az ağrı ve hızlı iyileşme avantajları nedeniyle apendektomidir; ancak seçilmiş komplike olmayan vakalarda medikal tedavi seçenekleri de literatürde tartışılmaktadır. Gebeler, yaşlılar ve immün yetmezliği olan hastalar gibi özel popülasyonlarda tanı ve yönetim süreçleri atipik seyredebildiğinden daha dikkatli bir yaklaşım gerektirir. Ayrıca apendektomi materyallerinde nadiren karsinoid tümör veya adenokarsinom gibi neoplazmlara rastlanabilmektedir.
Acute appendicitis is a clinical condition resulting from the obstruction of the appendiceal lumen and stands as one of the most frequently performed emergency surgical operations today. Typically observed during the second and third decades of life, the disease manifests with characteristic symptoms such as abdominal pain starting in the periumbilical region and localizing to the right lower quadrant, loss of appetite, nausea, and vomiting. While history and physical examination findings (McBurney tenderness, rebound, Rovsing sign) constitute the cornerstone of the diagnostic process, imaging modalities such as USG, CT, or MRI are utilized alongside leukocytosis and CRP monitoring to support the diagnosis. Appendectomy remains the gold standard for treatment, particularly due to the advantages of less pain and faster recovery offered by the laparoscopic method; however, medical treatment options for selected uncomplicated cases are also discussed in the literature. Special populations, such as pregnant women, the elderly, and immunocompromised patients, require a more cautious approach as diagnostic and management processes can follow an atypical course. Additionally, neoplasms such as carcinoid tumors or adenocarcinomas are occasionally encountered in appendectomy specimens.
Referanslar
Eliis H. Appendix. In: SchwartzSI,ed. Maingot’s Abdominal Operations, 8th ed, vol. 2. Norwalk: Appleton-Century-Crofts; 1985:1255.
May Day of 1961 and Self-appendectomy with Novocaine in Antarctica: Leonid Rogozov's 0.5% Solution?. Anesthesiology. 2019;131(4):768. doi:10.1097/ALN.0000000000002980
Jaffe BM, Berger DH. The appendix. In: Schwartz's Principles of Surgery, 8th ed, Schwartz SI, Brunicardi CF (Eds), McGraw-Hill Companies, New York 2005
Mulholland MW, Lillemoe KD, Doherty GM, et al. Greenfield's Surgery: Scientific Principles and Practice, 4th ed, Lippincott Williams & Wilkins, Philadelphia 2005
Brunicardi, F., et al. (2014) Schwartz’sPrinciples of Surgery. 10th Edition, McGraw-HillEducation, New York. p:1241-1262
Buschard K, Kjaeldgaard A. Investigation and analysis of the position, fixation, length and embryology of the vermiform appendix. Acta Chir Scand. 1973;139(3):293-298.
Ilves I, Paajanen HE, Herzig KH, et al. Changing incidence of acute appendicitis and nonspecific abdominal pain between 1987 and 2007 in Finland. World J Surg 2011; 35:731.
Addiss DG, Shaffer N, Fowler BS, et al. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol 1990; 132:910.
Golz RA, Flum DR, Sanchez SE, et al. Geographic Association Between Incidence of Acute Appendicitis and Socioeconomic Status. JAMA Surg 2020; 155:330.
Stringer MD. Acute appendicitis. J Paediatr Child Health. 2017;53(11):1071-1076. doi:10.1111/jpc.13737
ErtekinC.(2009).AcilCerrahi,İstanbul. NobelTıpKitabevi
Berry J, Malt RA. Appendicitis near its centenary. AnnSurg.
1984;200:567-575.
Taviloğlu K: (2002) Akut Apandisit ve Apandiks Hastalıkları. In: Kalaycı G, Acarlı K, Demirkol K, Ertekin C, Özmen V, Sökücü N, Editörler. Genel Cerrahi. İstanbul. Nobel tıp kitabevi: s. 259-70
Prystowsky JB, Pugh CM, Nagle AP: Current problems in surgery. Appendicitis. CurrProblSurg42:688–742, 2005.
Wray CJ, Kao LS, Millas SG, et al: Acute appendicitis: Con- troversies in diagnosis and management. CurrProblSurg50:54–86, 2013.
Birkhahn RH, Briggs M, Van Deusen SK, et al: Classifaying patients suspected or appendicitis with regard to likehood. American J Sure. 141(4): 2006.
Ünal Y. A newandearly marker in thediagnosis of acutecomplicatedappendicitis: immaturegranulocytes. Ulus Travma Acil Cerrahi Derg. 2018;24(5):434-439. doi:10.5505/tjtes.2018.91661
Parks NA, Schroeppel TJ: Update on imaging for acute appendicitis. Surg Clin North Am 91:141–154, 2011.
Birnbaum BA, Wilson SR: Appendicitis at the millennium. Radiology215:337–348, 2000.
Brown MA: Imaging acute appendicitis. Semin Ultrasound CT MR 29:293–307, 2008.
Jones K, Pena AA, Dunn EL, et al: Are negative appendectomies still acceptable? Am J Surg: 188(6): 2004
Antoniou SA, Mavridis D, Kontouli KM, et al. EAES rapid guideline: appendicitis in the elderly. Surg Endosc 2021; 35:3233.
Fan SM, Grigorian A, Smith BR, et al. Geriatric patients undergoing appendectomy have increased risk of intraoperative perforation and/or abscess. Surgery 2020; 168:322.
Paajanen H, Kettunen J, Kostiainen S. Emergency appendectomies in patients over 80 years. Am Surg 1994; 60:950.
Harrell AG, Lincourt AE, Novitsky YW, et al. Advantages of laparoscopic appendectomy in the elderly. Am Surg 2006; 72:474.
Guller U, Hervey S, Purves H, et al. Laparoscopic versus open appendectomy: outcomes comparison based on a large administrative database. Ann Surg 2004; 239:43.
Carpenter SG, Chapital AB, Merritt MV, et al. Increased risk of neoplasm in appendicitis treated with interval appendectomy: single-institution experience and literature review. Am Surg 2012; 78:339.
Flum DR, Steinberg SD, Sarkis AY, et al. Appendicitis in patients with acquired immunodeficiency syndrome. J Am Coll Surg 1997; 184:481.
Bova R, Meagher A. Appendicitis in HIV-positive patients. Aust N Z J Surg 1998; 68:337.
Whitney TM, Macho JR, Russell TR, et al. Appendicitis in acquired immunodeficiency syndrome. Am J Surg 1992; 164:467.
Ciarrocchi A, Amicucci G. Laparoscopic versus open appendectomy in obese patients: A meta-analysis of prospective and retrospective studies. J Minim Access Surg 2014; 10:4.
Tamir IL, Bongard FS, Klein SR. Gebe hastada akut apandisit. Ben J Surg 1990; 160:571.
Mourad J, Elliott JP, Erickson L, et al. Hamilelikte apandisit: uzun süredir devam eden klinik inançlarla çelişen yeni bilgiler. J ObstetGynecol 2000; 182:1027.
Hodjati H, Kazerooni T. Gravid hastada apendiksin yeri: yerleşik kavramın yeniden değerlendirilmesi. Int J GynaecolObstet 2003; 81:245.
Popkin CA, Lopez PP, Cohn SM, et al. Apandisitli hamile kadınlar için tercih edilen insizyon, McBurney'in görüşüdür. Ben J Surg 2002; 183:20.
Mahmoodian S. Gebeliği komplike eden apandisit. Güney Med J 1992; 85:19.
Andersen B, Nielsen TF. Appendicitis in pregnancy: diagnosis, management and complications. Acta Obstet Gynecol Scand 1999; 78:758.
Al-Fozan H, Tulandi T. Safety and risks of laparoscopy in pregnancy. Curr Opin Obstet Gynecol 2002; 14:375.
Treves F. A series of cases of relapsing typhlitis treated by operation. BMJ. 1893.
Varadhan KK, Neal KR, Lobo DN. Safety and efficacy of antibiotics compared with appendicectomy for treatment of uncomplicated acute appendicitis: meta-analysis of randomised controlled trials. BMJ 2012; 344: e2156.
Drake FT, Mottey NE, Farrokhi ET, et al. Time to appendectomy and risk of perforation in acute appendicitis. JAMA Surg2014; 149: 837–44.
Lefrancois M, Lefevre JH, Chafai N, et al. Management of acute appendicitis in ambulatory surgery: is it possible? How to select patients? Ann Surg2015; 261: 1167–72.
Willemsen PJ, Hoorntje LE, Eddes EH, et al: The need for interval appendectomy after resolution of an appendiceal mass questioned. DigSurg19:216–220, discussion 221, 2002.
Furman MJ, Cahan M, Cohen P, et al: Increased risk of mucinous neoplasm of the appendix in adults undergoing interval appendectomy. JAMA Surg148:703–706, 2013.
Humes DJ, Simpson J: Acute appendicitis. BMJ: 333: 530-534, 2006.
Fisher KS, Ross DS. Guidelines for therapeutic decision in inci-dental appendectomy. SurgGynecolObstet. 1990;171:95-98.
Semm K. Endoscopicappendectomy. Endoscopy. 1983;15(2):59-64. doi:10.1055/s-2007-1021466
Frazee RC, Roberts JW, Symmonds RE, et al. A prospective randomized trial comparing open versus laparoscopic appendectomy. AnnSurg. 1994;219(6):725-728; discussion 728-731.
Martin LC, Puente I, Sosa JL, et al. Open versus laparoscopic appendectomy. A prospective randomized comparison. AnnSurg. 1995;222(3):256-261; discussion 261-262.
McCall JL, Sharples K, Jadallah F. Systematic review of randomized controlled trials comparing laparoscopic with open appendicectomy. Br J Surg. 1997;84(8):1045-1050.
Golub R, Siddiqui F, Pohl D. Laparoscopic versus open appendectomy: a metaanalysis. J Am Coll Surg. 1998;186(5):545-553.
Sauerland S, Lefering R, Neugebauer E. Laparoscopic versus open surgery for suspected appendicitis. Cochrane Database Syst Rev. 2004;(4):CD001546
Di Saverio S. Emergency laparoscopy: a new emerging discipline for treating abdominal emergencies attempting to minimize costs and invasiveness and maximize outcomes and patients’ comfort. J TraumaAcuteCareSurg2014; 77: 338–50.
Chen JM, Geng W, Xie SX, et al. Single-incision versus conventional three-port laparoscopic appendectomy: a meta-analysis of randomized controlled trials. Minim Invasive Ther Allied Technol2015; published online Jan 20. DOI:10.3109/13645706.2014.995675.
Mui LM, Ng CS, Wong SK, et al. Optimum duration of pro- phylactic antibiotics in acute non-perforated appendicitis. ANZ J Surg. 2005;75:425-428.
Taylor E, Berjis A, Bosch T, et al. The efficacy of postoperative oral antibiotics in appendicitis: a randomized prospective double-blinded study. Am Surg. 2004;70:858-862.
Teixeira PG, Demetriades D: Appendicitis: Changing per- spectives. AdvSurg47:119–140, 2013.
Townsend, J. C. M., Beauchamp, R. D., Evers, B. M., &Mattox, K. L. (2016). Sabistontextbook of surgery (20th ed.). Elsevier -HealthSciencesDivision. p:1296-1311
.McCusker ME, Cote TR, Clegg LX, et al. Primary malignant neoplasms of the appendix: a population-based study from the Surveillance, Epidemiology and End Results program, 1973–1998. Cancer. 2002;94:3307-3312.
Sugarbaker PH, Bijelic L, Chang D, et al: Neoadjuvant FOLFOX chemotherapy in 34 consecutive patients with mucinous peritoneal carcinomatosis of appendiceal origin. J Surg Oncol 102:576–581, 2010.