Pediatrik Hastalarda Pankreas Cerrahisi
Özet
Özetlenen bu çalışma, çocuklarda yetişkinlerden farklı bir profil sergileyen pediatrik pankreas hastalıklarını ve bunların cerrahi yönetimini kapsamlı bir şekilde incelemektedir. Çocuklarda cerrahi müdahale gerektiren durumlar genellikle doğumsal anomaliler, travmalar ve nadiren görülen tümörlerden kaynaklanmaktadır. Pankreasın hayati fonksiyonları ve kritik vasküler yapılara yakınlığı nedeniyle, embriyolojik gelişimin ve anatomik varyasyonların bilinmesi, cerrahi başarının temelini oluşturur. Çalışmada distal pankreatektomi, near-total pankreatektomi ve Roux-N-Y pankreatikojejunostomi gibi yaygın tekniklerin yanı sıra; anüler pankreas, pankreas divisum ve pankreatik psödokistler gibi spesifik durumlar detaylandırılmıştır. Pankreatoblastom ve insülinoma gibi pediatrik neoplazmların yönetimi de ele alınırken, bu vakaların multidisipliner merkezlerde takip edilmesi gerektiği vurgulanmıştır. Sonuç olarak, çocukların yetişkinlerin küçük birer versiyonu olmadığı, konservatif tedaviye yanıt kapasitelerinin yüksekliği göz önünde bulundurularak agresif cerrahilerden kaçınılması gerektiği belirtilmektedir.
This study provides a comprehensive analysis of pediatric pancreatic diseases and their surgical management, highlighting that children exhibit a profile distinct from adults. Surgical interventions in pediatric patients typically stem from congenital anomalies, trauma, and rare tumors. Due to the pancreas's vital functions and proximity to critical vascular structures, a deep understanding of embryological development and anatomical variations is essential for surgical success. The text details common techniques such as distal pancreatectomy, near-total pancreatectomy, and Roux-en-Y pancreaticojejunostomy, while also addressing specific conditions like annular pancreas, pancreas divisum, and pancreatic pseudocysts. The management of pediatric neoplasms, including pancreatoblastoma and insulinoma, is discussed with an emphasis on the necessity of multidisciplinary care in specialized centers. Ultimately, the study concludes that children are not merely small versions of adults; their high capacity for responding to conservative treatment must be recognized, and aggressive surgeries should be avoided whenever possible.
Referanslar
Sadler TW. Development of the gastrointestinal tract. Langman’s medical embryology. China: Lippincott Williams and Wilkins; 2010. 222-3.
Kockel L, Storm A, Delacour A, et al. Anamylase/cre transene marks the whole endoderm but the primordia of liver and ventral pancreas. Genesis 2006;44:287-96.
Schoenwolf GC, Bleyl SB, Brauer PR, et al. Development of the gastrointestinal tract. Larsen’s human embryolog. China: Elsevier; 2009. 450-2.
Klimstra DS, Hruban RH, Pitman MB. Pancreas. Mills SE eds. Histology for pathologists. 3. Edition. USA, Lippincott Williams and Wilkins, 2007; 723-760.
Ceyhan GO, Michalski CW, Demir İE,et al. Pancreatic pain. Best Practice and Research Clinical Gastroenterology. 2008; 22: 31-44.
Brunicardi F, Brandt M, Andersen D, et al. The Pancreas. Schwartz’s Principles of Surgery, 1265-1334.USA : McGraw Hill Medical Publishing, 2005
Townsend MC, Beauchamp D, Evers BM, et al. Sabiston Textbook of General Surgery 20th edition,2016. USA: Elsevier
Clavien PA, Sarr MGu, Fong Y. Pancreas Atlas of Upper Gastrointestinal and Hepato-Pancreato-Biliary Surgery,2007; 725-949.USA: Springer.
Beckingham IJ. Acute Pancreatitis, Chronic Pancreatitis, Pancreatic Tumours. ABC of Liver, Pancreas and Gall Bladder First Edition. 2001; 33-44.UK: BMJ Books
Carroll M. Harmon, Arnold G. Coran. The Pancreas. Pediatric Surgery 7th edition, 2012; 1371-85.USA: Elsevier
Tadokoro H, Takase M, Nobukawa B. Development and Congenital Anomalies of the Pancreas. Anatomy Research International Volume 2011.
Başaklar C. Pankreatit, Pankreas Kist ve Tümörleri. Bebek ve Çocukların Cerrahi ve Ürolojik Hastalıkları 1. baskı. 2006; 1997-2019.Ankara : Palme Yayınevi
Lopez MJ. The changing incidence of acute pancreatitis in children: a single-institution perspective. J Pediatr 2002;140(5):622-4.
De Banto JR, Goday PS, Pedroso MR, et al. Multi -center Pancreatic Study Group. Acute pancreatitis in children. Am J Gastroenterol 2002;97(7):1726-31.
Choi BH, Lim YJ, Yo on CH, et al. Acute pancreatitis associated with biliary disease in children. J Gastroenterol Hepatol 2003;18(8):915-21.
Shet NS, Cole BL, Iyer RS Imaging of Pediatric Pancreatic Neoplasms With Radiologic Histopathologic Correlation. AJR 2014; 202:1337–48.
Nydeg ger A, Couper RT, Oliver MR. Childhood pancreatitis. J Gastroenterol and Hepatol 2006;21(3):499-509.
Carachi R, Grosfeld JL. Pancreatic Neoplasms in Children. The Surgery of Childhood Tumor 3rd Edition, 1998; 303-23.
Tucker MS. Pediatric Neoplasms of the Pancreas: A Review . Ann Clin Pathol 2(2): 1017.
Huang Y, Cao YF, Lin JL, et al. Acinar cell cystadenocarcinoma of the pancreas in a 4-year-old child. Pancreas. 2006;33(3):311–2.
Perez EA, Gutierrez JC, Koniaris LG, et al. Malignant pancreatic tumors: incidence and outcome in 58 pediatric patients. J Pediatr Surg. 2009;44(1):197–203.
Cheuk W, Beavon I, Chui DT, et al. Extrapancreatic solid pseudo- papillary neoplasm: report of a case
Classification of tumors of the digestive system, 4th ed. Lyon: International Agency for Research on Cancer, World Health Organization: 2010. doi: 10.1111/his.13975
Kouvaraki MA, Shapiro SE, Cote GJ, et al. Management of pancreatic endocrine tumors in multiple
Ishikawa T, Itoh A, Kawashima H, et al. Usefulness of EUS combined with contrast-enhancement in the differential diagnosis of malignant versus benign and preoperative localization of pancreatic endocrine tumors. Gastrointest Endosc. 2010;71(6):951–9.
Bushnell DL, Baum RP. Endocrinol Metab Clin North Am. 2011;40(1):153–62.
Schettini ST, Ribeiro RC, Facchin CG, et al. Gastrinoma in child- hood: case report and update on diagnosis and treatment. Eur J Pediatr Surg. 2009;19(1):38–40.
Brenner RW, Sank LI, Kerner MB, et al. Resection of a vipoma of the pancreas in a 15-year-old girl. J Pediatr Surg. 1986;21(11): 983–5.
Fanjiang G, Guelrud M, Gupta M, et al. Intraductal papillary- mucinous neoplasm of the pancreas in a 14-year-old. J Pediatr Gastroenterol Nutr. 2007;44(2):287–90.
Mukai M, Takamatsu H, Noguchi H, et al. Post-pubertal mucinous cystadenoma of the pancreas. Pediatr Surg Int. 2001;17(7):545–8.
National Cancer Instute (2021) Surveillance, Epidemiology and End Results (SEER) Program, National Cancer Institute, National Institutes of Health, Bethesda. ( 2021 yılında www.seer.cancer.gov adresinden ulaşılmıştır)