Pankreas Hastalıklarında Girişimsel Radyoloji
Özet
Girişimsel radyoloji; pankreas kanseri, nekroz, psödokist ve vasküler komplikasyonların tanı ve tedavisinde minimal invaziv yöntemler sunarak hasta yaşam kalitesini artırmaktadır. Tanı aşamasında USG veya BT eşliğinde yapılan perkütan biyopsiler, özellikle tru-cut biyopsi yöntemiyle %95’e varan doğruluk oranlarına ulaşmaktadır. Akut pankreatit sonrası gelişen sıvı koleksiyonları ve psödokistlerin yönetiminde perkütan drenaj %80-90 başarı oranıyla etkin bir seçenek olup cerrahi ihtiyacını azaltmaktadır. Pankreatik nekroz durumunda ise perkütan nekrozektomi gibi kapalı yöntemler, cerrahinin yüksek mortalite riskine karşı güvenli bir alternatif sunar. Ayrıca safra yolu tıkanıklıklarında ve pankreatik kanal darlıklarında uygulanan stentleme ve perkütan transhepatik kolanjioskopi işlemleri, kanal basıncını normalleştirerek ağrı ve sarılık gibi semptomları hızla iyileştirir. Komplikasyon riskini minimize etmek için deneyimli radyologlar tarafından uygun iğne seçimi ve görüntüleme rehberliği kritik önem taşımaktadır. Sonuç olarak girişimsel radyoloji, modern tıpta pankreas hastalıklarının yönetiminde cerrahiye alternatif veya tamamlayıcı, düşük morbiditeli ve yüksek etkili çözümler sağlamaktadır.
Interventional radiology provides minimal invasive methods for the diagnosis and treatment of pancreatic cancer, necrosis, pseudocysts, and vascular complications, thereby enhancing patient quality of life. During the diagnostic phase, percutaneous biopsies guided by USG or CT, particularly through the tru-cut biopsy method, reach accuracy rates of up to 95%. In managing fluid collections and pseudocysts developed after acute pancreatitis, percutaneous drainage is an effective option with an 80-90% success rate, reducing the need for surgery. In cases of pancreatic necrosis, closed methods such as percutaneous necrosectomy offer a safe alternative to the high mortality risks associated with open surgery. Furthermore, stenting and percutaneous transhepatic cholangioscopy procedures applied in biliary obstructions and pancreatic duct strictures rapidly improve symptoms like pain and jaundice by normalizing ductal pressure. To minimize the risk of complications, appropriate needle selection and imaging guidance by experienced radiologists are of critical importance. Consequently, interventional radiology provides low-morbidity and highly effective solutions as an alternative or complement to surgery in the management of pancreatic diseases in modern medicine.
Referanslar
Uysal A, Unal E, Karaosmanoglu AD, et al. The role of interventional radiology in the treatment of patients with pancreatic cancer. Br J Radiol. 2021;94(1118):20200702. doi: 10.1259/bjr.20200702.
Xin Y, Yang Y, Chen Y, et al. Safety and efficacy of ultrasound-guided percutaneous coaxial core biopsy of pancreatic lesions: a retrospective study. J Ultrasound. 2021;24(3):269-277. doi: 10.1007/s40477-020-00487-2.
Chen PT, Liu KL, Cheng TY, et al. Chang CC, Chang YC. Indirect percutaneous core needle biopsy of solid pancreatic or peripancreatic lesions. Abdom Radiol (NY). 2019 Jan;44(1):292-303.
Nabahati M, Moazezi Z, Fartookzadeh S, et al. The comparison of accuracy of ultrasonographic features versus ultrasound-guided fine-needle aspiration cytology in diagnosis of malignant thyroid nodules. J Ultrasound. 2019;22(3):315–321. doi: 10.1007/s40477-019-00377-2.
Stella SF, Van Borsel M, Markose G, et al. Image-Guided Percutaneous Biopsy for Pancreatic Lesions: 10-Year Experience in a Tertiary Cancer Center. Can Assoc Radiol J. 2019 ;70(2):199-203. doi: 10.1016/j.carj.2018.10.014.
XuK, ZhouL, LiangB, et al.Safety and accuracy of percutaneous core needle biopsy in examining pancreatic neoplasms. Pancreas 2012;41:649e51. doi: 10.1097/MPA.0b013e3182374f27.
Zamboni GA, D’Onofrio M, Idili A, et al. Ultrasound-guided percutaneous fine-needle aspiration of 545 focal pancreatic lesions. AJR Am J of Roentgenol 2009;193:1691e5. doi: 10.2214/AJR.09.2958.
Bhatti I, Ojo D, Dennison AR, et al. Percutaneous Pancreatic Biopsies-Still an Effective Method for Histologic Confirmation of Malignancy. Surg Laparosc Endosc Percutan Tech. 2016 Aug;26(4):334-7. doi: 10.1097/SLE.0000000000000288.
Mallery JS, Centeno BA, Hahn PF, et al. Pancreatic tissue sampling guided by EUS, CT/US, and surgery: a comparison of sensitivity and specificity. Gastrointest Endosc. 2002;56: 218–224. doi: 10.1016/s0016-5107(02)70181-8.
Roy A, Kim M, Hawes R, et al. Changing trends in tissue acquisition in malignant pancreatic neoplasms. J Gastroenterol Hepatol. 2016;31:501–505. doi: 10.1111/jgh.13081.
Tian G, Ye Z, Zhao Q, et al. Complication incidence of EUS-guided pancreas biopsy: A systematic review and meta-analysis of 11 thousand population from 78 cohort studies. Asian J Surg. 2020 Nov;43(11):1049-1055. doi: 10.1016/j.asjsur.2019.12.011.
Katanuma A, Maguchi H, Yane K, et al. Factors predictive of adverse events associated with endoscopic ultrasound-guided fine needle aspiration of pancreatic solid lesions. Dig Dis Sci. 2013 Jul;58(7):2093-9. doi: 10.1007/s10620-013-2590-4.
Tian G, Ye Z, Zhao Q, et al. Complication incidence of EUS-guided pancreas biopsy: A systematic review and meta-analysis of 11 thousand population from 78 cohort studies. Asian J Surg. 2020 Nov;43(11):1049-1055. doi: 10.1016/j.asjsur.2019.12.011.
Yamaguchi H, Morisaka H, Sano K, et al. Seeding of a Tumor in the Gastric Wall after Endoscopic Ultrasound-guided Fine-needle Aspiration of Solid Pseudopapillary Neoplasm of the Pancreas. Intern Med. 2020;59(6):779-782. doi: 10.2169/internalmedicine.3244-19.
Acton HJ, Mulholland D, Torreggiani WC. Quantification of the impact of interventional radiology in the management of acute pancreatitis. Ir J Med Sci. 2019;188(4):1195-1200. doi: 10.1007/s11845-019-01970-4.
Foster BR, Jensen KK, Bakis G, et al. Revised Atlanta classification for acute pancreatitis: a pictorial essay. Radiographics 2016;36(3):675–687. doi: 10.1148/rg.2016150097.
Foster BR, Jensen KK, Bakis G, et al. Revised Atlanta Classification for Acute Pancreatitis: A Pictorial Essay. Radiographics. 2016;36(3):675-87. doi: 10.1148/rg.2016150097.
Uysal A, Akhan O. "Pankreasta Girişimsel Radyoloji." TRD seminerleri 2019
Kwon YM, Gerdes H, Schattner MA, et al. Management of peripancreatic fluid collections following partial pancreatectomy: a comparison of percutaneous versus EUS-guided drainage. Surg Endosc. 2013 Jul;27(7):2422-7. doi: 10.1007/s00464-012-2752-z.
Warshaw AL, Rattner DW. Timing of surgical drainage for pancreatic pseudocyst. Clinical and chemical criteria. Ann Surg 1985; 202: 720-4. doi: 10.1007/s00464-012-2752-z.
Thomson JE, Van SM, Brand M, et al. Managing Infected Pancreatic Necrosis. Chirurgia. 2018;113(3):291-299. doi: 10.21614/chirurgia.113.3.291.
Baron TH, DiMaio CJ, Wang AY, et al. American Gastroenterological Association Clinical Practice Update: Management of Pancreatic Necrosis. Gastroenterology. 2020;158(1):67-75. doi: 10.21614/chirurgia.
Wang GJ, Gao CF, Wei D, et al. Acute pancreatitis: etiology and common pathogenesis. World J Gastroenterol. 2009;15(12):1427-30. doi: 10.3748/wjg.15.1427.
Lund H, Tønnesen H, Tønnesen MH, et al. Long-term recurrence and death rates after acute pancreatitis. Scand J Gastroenterol. 2006;41:234–238. doi: 10.1080/00365520510024133.
Tringali A, Bove V, Vadalà di Prampero SF, et al. Long-term follow-up after multiple plastic stenting for refractory pancreatic duct strictures in chronic pancreatitis. Endoscopy. 2019;51(10):930-935. doi: 10.1055/a-0959-6163.
Costamagna G, Bulajic M, Tringali A et al. Multiple stenting of refractory pancreatic duct strictures in severe chronic pancreatitis: longterm results. Endoscopy 2006; 38: 254 – 259. doi: 10.1055/s-2005-921069.
Hatzidakis A, Venetucci P, Krokidis M, et al. Percutaneous biliary interventions through the gallbladder and the cystic duct: What radiologists need to know. Clin Radiol. 2014 Dec;69(12):1304-11. doi: 10.1016/j.crad.2014.07.016.
Miyayama S, Matsui O, Akakura Y, et al. Percutaneous cholecy stochole doc hostomy for chole cystitis and cystic duct obstruction in gallbladder carcinoma. J Vasc Interv Radiol 2003;14:261e4. doi: 10.1097/01.rvi.0000058330.82956.8a.
Ahmed O, Mathevosian S, Arslan B. Biliary Interventions: Tools and Techniques of the Trade, Access, Cholangiography, Biopsy, Cholangioscopy, Cholangioplasty, Stenting, Stone Extraction, and Brachytherapy. Semin Intervent Radiol. 2016;33(4):283-290. doi: 10.1055/s-0036-1592327.
Ponchon T, Genin G, Mitchell R. et al.Methods, indications, and results of percutaneous choledo choscopy. A series of 161 procedures. Ann Surg. 1996;223(1):26–36. doi: 10.1097/00000658-199601000-00005.