Akut Radyasyon Sendromunda Hemşirelik Bakımı

Yazarlar

Vacide Aşık Özdemir
https://orcid.org/0000-0001-6421-1518

Özet

Akut Radyasyon Sendromu (ARS), yüksek dozda penetran radyasyona maruz kalınması sonucu saatler, günler veya haftalar içinde gelişen, acil tanı ve tedavi gerektiren kritik bir klinik tablodur. Sendrom patofizyolojik olarak prodromal, latent, açık hastalık ve final olmak üzere dört belirgin evre halinde ilerler. Alınan radyasyonun düzeyine bağlı olarak hematopoetik (1-8 Gy), gastrointestinal (6-20 Gy) ve nörovasküler (20-50 Gy) olmak üzere üç alt sendrom ortaya çıkar. Tanı aşamasında mutlak lenfosit sayısındaki azalma ile kromozomal sapma analizleri en güvenilir laboratuvar parametreleridir. Tıbbi yönetim organ sistemlerine göre kategorize edilerek kan ürünleri replasmanı, büyüme faktörleri ve sitokin uygulamalarını içerir. Bu süreçte hemşirelik bakımı, çoklu organ yetmezliği yönetimine benzer bir yaklaşım sergileyerek tedavinin merkezinde yer alır. Ağır vakalarda ters bariyer hemşireliği uygulanması, triaj, dekontaminasyon, yara bakımı ve psikolojik destek hemşirelerin temel sorumluluklarındandır. Sağlık personeli ise maruziyeti en aza indirmek için zaman, mesafe ve kalkan ilkelerine uymalı, uygun kişisel koruyucu ekipman kullanmalıdır.

Acute Radiation Syndrome (ARS) is a critical clinical condition requiring emergency diagnosis and treatment, which develops within hours, days, or weeks following exposure to high-dose penetrating radiation. The syndrome progresses pathophysiologically through four distinct phases: prodromal, latent, manifest illness, and final. Depending on the radiation dose, three sub-syndromes emerge: hematopoietic (1-8 Gy), gastrointestinal (6-20 Gy), and neurovascular (20-50 Gy). In diagnosis, a decrease in absolute lymphocyte counts and chromosomal aberration analyses serve as the most reliable laboratory parameters. Medical management is categorized by organ systems and involves blood product replacement, growth factors, and cytokine administrations. Nursing care plays a central role in treatment success, adopting an approach similar to multi-organ failure management. Implementing reverse barrier nursing in severe cases, along with screening, triage, decontamination, wound care, and psychological support, constitute the primary responsibilities of nurses. Healthcare personnel must adhere to time, distance, and shielding principles and use appropriate personal protective equipment to minimize exposure.

Referanslar

Blakely WF, Ossetrova NI, Whitnall MH, et al. Multiple parameter radiation injury assessment using a nonhuman primate radiation model-biodosimetry applications. Health Physics. 2010;98(2):153–159.

Bader JL, Nemhauser J, Chang F, et al. Radiation event medical management (REMM): website guidance for health care providers. Prehospital Emergency Care: Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors. 2008;12(1):1–11.

Hatchett RJ, Kaminski JM, Goans RE, et al. Nuclear and radiological events. In: Koenig K.L., Schultz C.H., eds. Koenig and Schultz’s Disaster Medicine: Comprehensive Principles and Practices. 2009;477–510, Cambridge, England: Cambridge University Press.

Linet MS, Kazzi Z, Paulson JA. Council on environmental health. Pediatric considerations before, during, and after radiological or nuclear emergencies. Pediatric. 2018;142(6):e20183001.

Garau MI, Calduch ML, López EC. Radiobiology of the acute radiation syndrome. Reports of Practical Oncology and Radiotherapy: Journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology. 2011;16(4):123–130.

De-Coursey E. Human pathological anatomy of ionizing radiation effects of the atomic bomb explosions. Mil Surg. 1948;102:427–32.

Denham JW, Hauer-Jensen M, Peters LJ. Is it time for a new formalism to categorize normal tissue radiation injury? Int J Radiat Oncol Biol Phys. 2001;50:1105–1106.

Pedigo T. (2005) Radiological weapons in Currance PL. Medical response to weapons of mass destruction. Mosby/Jems,wyd.1.

Menon SS, Uppal M, Randhawa S, et al. Radiation Metabolomics: Current Status and Future Directions. Frontiers in Oncology. 2016;6:20.

Dainiak N, Waselenko JK, Armitage JO, et al. The hematologist and radiation casualties. Hematology. American Society of Hematology. Education Program. 2003:473–496.

Gourmelon P, Benderitter M, Bertho JM, et al. European consensus on the medical management of acute radiation syndrome and analysis of the radiation accidents in Belgium and Senegal. Health Physics. 2010;98(6):825–832.

Singh VK, Seed TM. An update on sargramostim for treatment of acute radiation syndrome. Drugs of Today (Barcelona, Spain: 1998). 2018;54(11):679–693.

Wang H, Mu X, He H, et al. Cancer Radiosensitizers. Trends in Pharmacological Sciences. 2018;39(1):24–48.

Mettler FA, Royal HD, Drum DE. (2006) Radiation accidents. In: Textbook of Pediatric Emergency Medicine, 5th ed, Fleisher GR, Ludwig S, Henretig FM (Eds), p.1033. Lippincott Williams & Wilkins, Philadelphia.

Newburger PE, Dale DC. Evaluation and management of patients with isolated neutropenia. Seminars in Hematology. 2013;50(3):198–206.

Kato TA. Human Lymphocyte Metaphase Chromosome Preparation for Radiation-Induced Chromosome Aberration Analysis. Methods in Molecular Biology (Clifton, NJ.), 2019;1984:1–6.

Cavallero, Riccobono D, Drouet M. MSC-Derived Extracellular Vesicles: New emergency treatment to limit the development of radiation-induced hematopoietic syndrome? Health Physics. 2020;119(1):21–36.

Qian L, Cen J. Hematopoietic stem cells and mesenchymal stromal cells in acute radiation syndrome. Oxidative Medicine and Cellular Longevit. 2020;2020:8340756.

Igaki H, Nakagawa K, Uozaki H, et al. Pathological changes in the gastrointestinal tract of a heavily radiation-exposed worker at the Tokai-mura criticality accident. Journal of Radiation Research. 2008;49(1):55–62.

Guo H, Chou WC, Lai Y, et al. Multi-omics analyses of radiation survivors identify radioprotective microbes and metabolites. Science. 2020;370(6516):eaay9097.

Meineke V, van Beuningen D, Sohns T, et al. Medical management principles for radiation accidents. Military Medicine. 2003;168(3):219–222.

Ye F, Ning J, Fardous Z, et al. Citrulline, A Potential Biomarker of Radiation-Induced Small Intestine Damage. Dose-Response: a Publication of International Hormesis Society. 2020;18(3):1559325820962341.

Ende M. Management of the acute radiation syndrome. Ann Intern Med. 2004;141(11):89.

Nair V, Karan DN, Makhani CS. Guidelines for medical management of nuclear/radiation emergencies. Medical Journal Armed Forces India. 2017;73(4):388–393.

Cerveny TJ, MacVittae TJ, Young RW. (1989). Acute radiation syndrome in humans. In: Walker RI, Cerveny TJ, eds. Medical Consequences of Nuclear Warfare. In: Zajtchuk R, Bellamy RF, eds. Textbook of Military Medicine. Washington, DC: Department of the Army, Office of The Surgeon General, Borden Institute.

Hall EJ. (2000) Acute effects of total-body irradiation. In: Hall EJ, eds. Radiobiology for the Radiologist. 5th ed.:124-135. Philadelphia Lippincott Williams & Wilkins.

Kato M, Chida K, Ishida T, et al. Occupational radiation exposure of the eye in neurovascular interventional physician. Radiation Protection Dosimetry. 2019;185(2):151–156.

Jackson WL Jr, Gallagher C, Myhand RC, et al. Medical management of patients with multiple org.an dysfunction arising from acute radiation syndrome. BJR Suppl. 2005;27:161–168.

Gourmelon P, Marquette C, Agay D, et al. Involvement of the central nervous system in radiationinduced multi-organ dysfunction and/or failure. BJR Suppl. 2005;27;62–68.

López M, Martín M. Medical management of the acute radiation syndrome. Reports of practical oncology and radiotherapy: Journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology. 2011;16(4):138–146.

West CM, Davidson SE, Elyan SA, et al. Lymphocyte radiosensitivity is a significant prognostic factor for morbidity in carcinoma of the cervix. International Journal of Radiation Oncology, Biology, Physics. 2001;51(1):10–15.

Dainiak N. Medical management of acute radiation syndrome and associated infections in a high-casualty incident. Journal of Radiation Research. 2018;59(suppl_2):ii54–ii64.

Liu X, Li C, Zheng K, et al. Chromosomal aberration arises during somatic reprogramming to pluripotent stem cells. Cell Division. 2020;15(1):12.

Okunieff P, Morgan D, Niemierko A, et al. Radiation dose-response of human tumors. International Journal of Radiation Oncology, Biology, Physics. 1995;32(4):1227–1237.

Petersen OB, Smith E, Van Opstal D, et al. Nuchal translucency of 3.0-3.4 mm an indication for NIPT or microarray? Cohort analysis and literature review. Acta Obstetricia et Gynecologica Scandinavica. 2020;99(6):765–774.

Elhajouji A, Lukamowicz-Rajska M. Flow cytometric determination of micronucleus frequency. Methods in Molecular Biology (Clifton, NJ.). 2013;1044:209–235.

Fliedner TM, Friesecke I, Beyrer K. (2001) (Eds): Medical Management of Radiation Accidents–Manual on the Acute Radiation Syndrome London: British Institute of Radiology.

Waselenko JK, MacVittie TJ, Blakely WF, et al. Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Annals of Internal Medicine. 2004;140(12):1037–1051.

Williams JP, McBride WH. After the bomb drops: a new look at radiation-induced multiple organ dysfunction syndrome (MODS). International Journal of Radiation Biology. 2011;87(8):851–868.

Dumont F, Le Roux A, Bischoff P. Radiation countermeasure agents: an update. Expert Opinion on Therapeutic Patents. 2010;20(1):73–101.

Müller K, Meineke V. Advances in the management of localized radiation injuries. Health Physics. 2010;98(6):843–850.

Rong X, Zhang G, Yang Y, et al. Transplanted antler stem cells stimulated regenerative healing of radiation-induced cutaneous wounds in rats. Cell Transplantation. 2020;29:963689720951549.

Messerschmidt O. Combined effects of radiation and trauma. Advances in Space Research: The Official Journal of the Committee on Space Research (COSPAR), 1989;9(10):197–201.

Tierney L, McPhee S, Papadakis M. (2002) Current medical diagnosis & treatment, 41st ed. 2002:1601-1603. New York, NY: Lange/McGraw-Hill.

Holdstock D, Waterston L. Nuclear weapons, a continuing threat to health. Lancet (London, England). 2000;355(9214):1544–1547.

Chan RJ, Webster J, Chung B, et al.(2014). Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials. BMC Cancer. 2014;14:53.

Marazziti D, Baroni S, Catena-Dell'Osso M, et al. Cognitive, psychological and psychiatric effects of ionizing radiation exposure. Current Medicinal Chemistry. 2012;19(12):1864–1869.

Adams TG, Sumner LE, Casagrande R. Estimating risk of hematopoietic acute radiation syndrome in children. Health Physics. 2017;113(6):452–457.

Medhora M, Gao F, Gasperetti T, et al. delayed effects of acute radiation exposure (deare) in juvenile and old rats: Mitigation by lisinopril. Health Physics. 2019;116(4):529–545.

Le Heron J, Padovani R, Smith I, et al. Radiation protectionof medical staff. Eur J Radiol. 2010;76(1):20-23.

Sayfalar

607-616

Gelecek

23 Ağustos 2022

Lisans

Lisans