D Vitamini ve Kolorektal Kanser İlişkisi
Özet
Kolorektal kanser gelişimi ve ilerlemesinde çevresel faktörler, genetik etkenler ve beslenme alışkanlıkları kritik rol oynamakta; özellikle D vitamini eksikliği bu hastalık için önemli bir risk faktörü olarak öne çıkmaktadır. Güneş ışığı, diyet ve takviyelerle alınan D vitamini, vitamin D reseptörleri (VDR) aracılığıyla hücre çoğalmasını baskılayıp apoptozu uyararak ve bağırsak florasını düzenleyerek antitümör etkiler göstermektedir. Yapılan klinik çalışmalar, cerrahi operasyon sonrası yüksek D vitamini seviyelerine sahip hastalarda nüks oranlarının azaldığını ve sağkalım süresinin arttığını kanıtlamaktadır.
Environmental factors, genetic predispositions, and dietary habits play a critical role in the development and progression of colorectal cancer, with vitamin D deficiency emerging as a significant risk factor. Vitamin D, obtained through sunlight, diet, and supplements, exerts antitumor effects via vitamin D receptors (VDR) by suppressing cell proliferation, inducing apoptosis, and regulating gut microbiota. Clinical studies demonstrate that patients with higher vitamin D levels after surgery experience lower recurrence rates and improved survival outcomes.
Referanslar
KannanT., Gazala K., Colorectal Cancer and Nutrition Nutrients 2019, 11, 164
Cheng, L., Eng, C., Nieman L.Z.,et.al. Trends in colorectal cancer incidence by anatomic site and disease stage in the United States from 1976 to 2005. Am. J. Clin. Oncol. 2011, 34, 573–580.
Siegel, R.L.,Miller K.D., Jemal A. Cancer statistics, 2018. CA Cancer J. Clin. 2018, 68, 7–30.
Siegel R.L., Miller K.D., Fedewa S.A.,et.al. Colorectal cancer statistics, 2017. CA Cancer J. Clin. 2017, 67, 177–193.
Finlay A., Macrae R.M.G., Seres D.,et.al. Colorectal Cancer: Epidemiology, Risk Factors, and Protective Factors. Available online: https://www.uptodate.com/contents/colorectal-cancer-epidemiologyrisk-factors-and-protective-factors (accessed on 24 December 2018).
Thrift A.P., Gong J., Peters U., et al. Mendelian Randomization Study of Body Mass Index and Colorectal Cancer Risk. Cancer Epidemiol. Biomarkers Prev. 2015, 24, 1024–1031.
McCullough M.L., Zoltick E.S., Weinstein S.J., et al. Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts. J. Natl. Cancer Inst. 2018.
Burkitt D.P., Walker A.R., Painter N.S. Dietary fiber and disease. JAMA 1974, 229, 1068–1074.
Kelly D., Yang, L., Pei Z. Gut Microbiota, Fusobacteria, and Colorectal Cancer. Diseases 2018, 6, 109.
Nosho K., Sukawa Y., Adachi Y., et al. Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer. World J. Gastroenterol. 2016, 22, 557–566.
Farhana L., Antaki F., Murshed F., et.al. Gut microbiome profiling and colorectal cancer in African Americans and Caucasian Americans. World J. Gastrointest. Pathophysiol. 2018, 9, 47–58.
Bingham S.A., Day N.E., Luben R.,et al. Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): An observational study. Lancet 2003, 361, 1496–1501.
Mehta R.S., Nishihara R., Cao Y., et al. Association of Dietary Patterns with Risk of Colorectal Cancer Subtypes Classified by Fusobacterium nucleatum in Tumor Tissue. JAMA Oncol. 2017, 3, 921–927.
Song M., Wu K., Meyerhard, J.A., et.al. Fiber Intake and Survival After Colorectal Cancer Diagnosis. JAMA Oncol. 2018, 4, 71–79.
Clark J.W., Sanoff H.K. Adjunctive Therapy for Patients with Resected Early Stage Colorectal Cancer: Diet, Exercise, NSAIDs, and Vitamin D. Available online: https://www.uptodate.com/contents/adjunctivetherapy-for-patients-with-resected-early-stage-colorectal-cancer-diet-exercise-nsaids-and-vitamin-d (accessed on 24 December 2018).
Meyerhardt J.A., Sato K., Niedzwiecki D., et al. Dietary glycemic load and cancer recurrence and survival in patients with stage III colon cancer: Findings from CALGB 89803. J. Natl. Cancer Inst. 2012, 104, 1702–1711.
Guercio B.J., Sato K., Niedzwiecki D., et al. Coffee Intake, Recurrence, and Mortality in Stage III Colon Cancer: Results from CALGB 89803 (Alliance). J. Clin. Oncol. 2015, 33, 3598–3607.
Hu Y., Ding M., Yuan C., et al. Association Between Coffee Intake After Diagnosis of Colorectal Cancer and Reduced Mortality. Gastroenterology 2018, 154, 916–926.
Fadelu T., Zhang S., Niedzwiecki D., et al. Nut Consumption and Survival in Patients with Stage III Colon Cancer: Results from CALGB 89803 (Alliance). J. Clin. Oncol. 2018, 36, 1112–1120.
Ballard-Barbash R., Friedenreich C.M., Courneya K.S., et.al. Physical activity, biomarkers, and disease outcomes in cancer survivors: A systematic review. J. Natl. Cancer Inst. 2012, 104, 815–840.
Baron J.A., Cole B.F., Sandler R.S., et al. A randomized trial of aspirin to prevent colorectal adenomas. N. Engl. J. Med. 2003, 348, 891–899.
Sandler R.S., Halabi S.,Baron J.A., et al. A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N. Engl. J. Med. 2003, 348, 883–890.
Ünlü A.,Kırca Ö,öğretmen İ ve ark. D vitamini ve kanserden koruma Akd Tıp D / Akd Med J / 2016; 2: 51-54
Tıp Enstitüsü Gıda ve Beslenme Kurulu.Kalsiyum ve D Vitamini İçin Diyet Referans Alımları. Washington, DC: Ulusal Akademi Yayınları, 2010.
Burcu Merve Aksu & Esra Tansu Sarıyer Kolorektal Kanser ve D Vitamini Journal of Health Services and Education; 4(2): 39-44
Buğrul F. Süt çocukluğu dönemindeki bebeklerin annelerine verilen D vitamininin çocuklardaki D vitamini düzeyine etkisi. 2011, İstanbul Üniversitesi Çocuk sağlığı Enstitüsü, Uzmanlık tezi, 86 sayfa, İstanbul, (Prof. Dr. E. Gülbin Gökçay
Meeker S, Seamons A, Maggio-Price L, et.al. Protective links between vitamin D, inflammatory bowel disease and colon cancer. World J Gastroenterol. 2016; 22(3): 933-948
Vurgun E, Evliyaoğlu O, Yıldırmak S. Kanıta dayalı laboratuvar: D vitamini yetersizlik sınırlarının belirlenmesi. Med Bull Haseki. 2016; 54: 76-82
Camara AB, Brandao IA. The role of vitamin D and sunlight incidence in cancer. Anti-Cancer Agent in Medical Chemistry. 2019; 19(11): 1418-1436.
Alptekin İM. Anti-Kanser Etkiler Işığında D vitamini ve Kanser. ACU Sağlık Bil Derg. 2017;2:70-74.
Akın H, Tözün N. Diet, Mikrobiota and Colorectal Cancer. J Clin Gastroenterol. 2014; 48(1): 67-69.
O’Neill AM, Burrington CM, Gillaspie EA, et al. High-fat westren diet-induced obesity contributes to increased tumor growth in mouse models of human colon cancer. Nutrition Research. 2016; 36: 1325-1334
Bastide NM, Chenni F, Audebert M et. al. A Central Role for Heme Iron in Colon Carcinogenesis Associated with Red Meat Intake. Cancer Research. 2015; 75(5): 870-879.
Qamar TR, Igbal S, Syed F, et. al. İmpact of novel prebiotic galacto-oligosaccharides on various biomarkers of colorectal cancer in wister rats. Int J Mol Sci. 2017; 18: 1785-1797
Rivera-Huerta, M, Lizárraga-Grimes V, Castro-Torres I,et. al. Functional Effects of Prebiotic Fructans in Colon Cancer and Calcium Metabolism in Animal Models. BioMed Research International. 2017: 1-10
Zamora-Ros R, Cayssials V, Jenab M, et. al. Dietary intake of total polyphenol and polyphenol classes and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. European Journal of Epidemiology. 2018; 33(11): 1063-1075
Bizzaro G, Antico A, Fortunato A, et.al. Vitamin D and Autoimmune Diseases: İs Vitamin D Receptor(VDR) Polymorphism the Culprit? IMAJ. 2017; 19(7): 438-443.
Gemma F.M ,María J.L, Piero C. , et.al. Mechanisms of action of vitamin D in colon cancer The Journal of Steroid Biochemistry and Molecular BiologyVolüme 185, January 2019, Pages 1-6
Al-Ghafari AB, Balamash KS, Doghaither AA. Relationship between serum vitamin D and calcium levels and vitamin D gene polymorphisms in colorectal cancer. BieMed Research İnternational. 2019. Doi: https://doi. org/10.1155/2019/8571541.
Lu R, Zhang YG, Xia Y, et.al. Imbalance of autophagy and apoptosis in intestinal epithelium laching the vitamin D receptor. FASEB J. 2019. doi: 10.1096/fj.201900727R
Zhou X, Chen C, Zhong Y, et al. Effect and mechanism of vitamin D on the development of colorectal cancer based on intestinal flora disorder. J Gastroenterol Hepatol. 2019; 35(6): 1023-1031.
Yang H, Wang Z, Jin M, et al. Effects of Vitamin D Receptor on Mucosal Barrier Proteins in Colon Cells under Hypoxic Environment. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019; 41(4): 506-511.
Ranji P, Agah S, Heydari Z,et.al. Effects of Lactobacillus acidophilus and Bifidobacterium bifidum probiotics on the serum biochemical parameters and the vitamin D and leptin receptor genes on mice colon cancer. Iranian Journal of Basic Medical Sciences. 2019; 22(6): 631- 636
Markotic A, Langer S, Kelava T, et al. Higher Post-Operative Serum Vitamin D Level is Associated with Better Survival Outcome in Colorectal Cancer Patients. Nutr Cancer. 2019; 71(7): 1078- 1085.
Fuchs MA, Yuan C, Sato K, Niedzwiecki D, Ye X, Saltz LB et al. Predicted Vitamin D Status and Colon Cancer Recurrence and mortality in CALGB 89803(Alliance). Annals of Oncology. 2017; 28(6): 1359–1367
