İlaçların Vitaminlerle Etkileşmesi

Yazarlar

Mahmut Özdemir
https://orcid.org/0000-0003-1124-6957

Özet

Modern tıp ve artan yaşlı nüfusla birlikte çoklu ilaç kullanımı, ilaçların vitamin ve minerallerle olan karmaşık etkileşimlerini klinik açıdan daha kritik hale getirmektedirÖzellikle kortikosteroidler, aspirin, diüretikler ve metformin gibi yaygın reçete edilen ilaçlar; D, C ve B12 gibi hayati vitaminlerin seviyelerini düşürerek osteoporoz, anemi ve nöropati gibi ciddi sağlık sorunlarına yol açabilmektedirBu etkileşimlerin farkında olunması, özellikle kronik hastalığı olan bireylerde tedavi başarısını artırmak ve komplikasyonları önlemek adına hekim ve eczacıların takibini zorunlu kılmaktadır.

 

Advances in medicine and an aging population have made the interaction between drugs and vitamins clinically significant due to increased multi-drug useCommon medications such as corticosteroids, diuretics, and metformin can deplete essential vitamins like D, C, and B12, potentially leading to complications such as osteoporosis and neuropathyRecognizing these interactions is vital for healthcare professionals to optimize treatment outcomes and prevent long-term nutritional deficiencies in patients with chronic conditions.

Referanslar

Economic and Financial Affairs. 2017. Underlying assumptions and projection methodologies. Institutional paper 065. European Commission November 2017

Hall M, Dondo TB, Yan AT, et al. Multimorbidity and survival for patients with acute myocardial infarction in England and Wales: Latent class analysis of a nationwide population-based cohort. PLoS Medicine, 2018, 15 (3). Article e1002501. 10.1371/journal.pmed.1002501

Puth MT, Klaschik M, Schmid M, et al. Prevalence and comorbidity of osteoporosis-a cross-sectional analysis on 10,660 adults aged 50 years and older in Germany. BMC Musculoskeletal Disorders, 2018, 19(1):144.

Smithburger PL, Buckley MS, Culver MA, et al. A multicenter evalu-ation of off-Label Medication use and associated adverse drug reactions in adult medical ICUs. Critical Care Medicine, 2015, 43(8):1612–21.

McCabe BJ. Prevention of food-drug interactions with special emphasis on older adults. Curr. Opin. Clin. Nutr. Metab. Care, 2004, 7, 21–26.

Samaras D, Samaras N, Lang PO, et al. Effects of widely used drugs on micronutrients: A story rarely told. Nutrition, 2013, 29, 605–610.

Blahos J, Care AD, Sommerville BA. The effect of betamethasone on duodenal calcium absorption and 1,25-dihydroxy vitamin D3 production in the chick. Horm. Metab. Res. 1983, 15, 197–200.

Canalis E. Clinical review83: Mechanisms of glucocorticoid action in bone: Implications to glucocorticoid-induced osteoporosis. J. Clin. Endocrinol. Metab. 1996, 81, 3441–3447.

Kim M-H, Lee G-S, Jung E-M, et al. The negative effect of dexamet-hasone on calcium-processing gene expressions is associated with a gluco-corticoid-induced calcium-absorbing disorder. Life Sci. 2009, 85, 146–152.

Kim M-H, Lee G-S, Jung E-M, et al. Dexamethasone differentially regulates renal and duodenal calcium-processing genes in calbindin-D9k and -D28k knockout mice. Exp. Physiol. 2009, 94, 138–151

Nielsen HK, Thomsen K, Eriksen EF, et al. The effects of high-dose glucocorticoid administration on serum bone gamma carboxyglutamic acid-containing protein, serum alkaline phosphatase and vitamin D metabolites in normal subjects. Bone Miner. 1988, 4, 105–113.

Ton FN, Gunawardene SC, Lee H, et al. Effects of low-dose prednisone on bone metabolism. J. Bone Miner. Res. 2005, 20, 464–470.

Van Staa TP, Leufkens HG, Cooper C. The Epidemiology of Corticosteroid-Induced Osteoporosis: A Meta-analysis. Osteoporos. Int. 2002, 13, 777–787

Briot K, Roux C. Glucocorticoid-induced osteoporosis. RMD Open 2015;1:e000014. doi:10.1136/rmdopen-2014- 000014 .

Hahn TJ, Halstead LR, Haddad JG. Serum 25-hydroxyvitamin D concentrations in patients receiving chronic corticosteroid therapy. J. Lab. Clin. Med. 1977, 90, 399–404.148.

Hahn TJ, Halstead LR, Baran DT. Effects off short term glucocorticoid administration on intestinal calcium absorption and circulating vitamin D metabolite concentrations in man. J. Clin. Endocrinol. Metab. 1981, 52, 111–115.

Homik J; Suarez-Almazor ME, Shea B, et al. Calcium and vitamin D for corticosteroid-induced osteoporosis. Cochrane Database Syst. Rev. 2000, CD000952.

Allen CS, Yeung JH, Vandermeer B, et al. Bisphosphonates for steroid-induced osteoporosis. Cochrane Database Syst. Rev. 2016, 10, CD001347.

Sahud MA, Cohen J. Effect of aspirin ingestion on ascorbic-acid levels in rheumatoid arthritis. Lancet, 1971, 1, 937–938.

Basu TK. Vitamin C-aspirin interactions. Int. J. Vitam. Nutr. Res. Suppl. 1982, 23, 83–90.

Loh HS, Wilson CWM. The Interactions of Aspirin and Ascorbic Acid in Normal Men. J. Clin. Pharmacol. 1975, 15, 36–45.

Dammann H-G, Saleki M, Torz M, et al. Effects of buffered and plain acetylsalicylic acid formulations with and without ascorbic acid on gastric mucosa in healthy subjects. Aliment. Pharmacol. Ther. 2004, 19, 367–374.

Konturek PC, Kania J, Hahn EG, et al. Ascorbic acid attenuates aspirin-induced gastric damage: Role of inducible nitric oxide synthase. J. Physiol. Pharmacol. 2006, 57 (Suppl 5), 125–136.

Rieck J, Halkin H, Almog S, et al. Urinary loss of thiamine is increased by low doses of furosemide in healthy volunteers. J. Lab. Clin. Med. 1999, 134, 238–243.

Zenuk C, Healey J, Donnelly J, et al. Thiamine deficiency in congestive heart failure patients receiving long term furosemide therapy. Can. J. Clin. Pharmacol. 2003, 10, 184–188.

Seligmann H, Halkin H, Rauchfleisch S, et al. Thiamine deficiency in patients with congestive heart failure receiving long-term furosemide therapy: A pilot study. Am. J. Med. 1991, 91, 151–155

Hanninen SA, Darling PB, Sole MJ, et al. The prevalence of thiamin deficiency in hospitalized patients with congestive heart failure. J Am Coll Cardio. 2006; 47:354-361.

McCabe-Sellers BJ, Sharkey JR, Browne BA. Diuretic medication therapy use and low thiamin intake in homebound older adults. J. Nutr. Elder. 2005, 24, 57–71.

Zangen A, Botzer D, Zanger R, Shainberg A. Furosemide and digoxin inhibit thiamine update in cardiac cells. Eur J Pharmacol. 1998; 361:151-155.

Prevalence of thiamine deficiency in patients on long-term diuretic therapy. J Pract Cardiovasc Sci, 2015;1:25-29.

Rocha RM, Silva GV, de Albuquerqe DL, et al. Influence of spironolactone therapy on thiamine blood levels in patients with heart failure. Arq Bras Cardiol, 2008; 90:324-328

Shimon I, Almog S, Vered Z, et al. Improved left ventricular function after thiamine supplementation in patients with congestive heart failure receiving long-term furosemide therapy. Am J Med, 1995:98:485-490.

Schoenenberger AW, Schoenenberger-Berzius R, Aufdermaus C, et al. Thiamine supplementation in symptomatic heart failure: a randomized, double-blind, placebo controlled, cross-over pilot study. Clin Res Cardiol, 2012; 101:159- 164.

DiNicolantonio JJ, Lavie CJ, Niazi AK, et al. Effects of thiamine on cardiac function in patients with systolic heart failure: Systematic review and meta-analysis of randomized, double-blind, placebo-controlled trials. Ochsner J. 2013, 15:495- 499

Lieberman FL, Bateman JR. Megaloblastic anemia possibly induced by triamterene in patients with alcoholic cirrhosis. Two case reports. Ann. Intern. Med. 1968, 68, 168–173.

Schalhorn A, Siegert W, Sauer H-J. Antifolate effect of triamterene on human leucocytes and on a human lymphoma cell line. Eur. J. Clin. Pharmacol. 1981, 20, 219–224)

Mason JB, Zimmerman J, Otradovec CL, et al. Chronic diuretic therapy with moderate doses of triamterene is not associated with folate deficiency. J. Lab. Clin. Med. 1991, 117, 365–369.

Morrow LE, Grimsley EW. Long-term diuretic therapy in hypertensive patients: Effects on serum homocysteine, vitamin B6, vitamin B12, and red blood cell folate concentrations. South. Med. J. 1999, 92,866–870.)

Westphal S, Rading A, Luley C, et al. Antihypertensive treatment and homocysteine concentrations. Metabolism, 2003, 52, 261–263.

Morrow LE, Grimsley EW. Long-term diuretic therapy in hypertensive patients: Effects on serum homocysteine, vitamin B6, vitamin B12, and red blood cell folate concentrations. South. Med. J. 1999, 92,866–870.)

Westphal S, Rading A, Luley C, et al. Antihypertensive treatment and homocysteine concentrations. Metabolism, 2003, 52, 261–263.

Rejnmark L, Vestergaard P, Pedersen AR; et al. Dose-effect relations of loop- and thiazide-diuretics on calcium homeostasis: A randomized, double-blinded Latin-square multiple cross-over study in postmenopausal osteopenic women. Eur. J. Clin. Investig. 2003, 33, 41–50.

Jones G, Nguyen T, Sambrook PN, et al. Thiazide diuretics and fractures: Can meta-analysis help? J. Bone Miner. Res. 1995, 10, 106–111

Aung K, Htay T. Thiazide diuretics and the risk of hip fracture. Cochrane Database Syst. Rev. 2011, CD005185.

Rejnmark L, Vestergaard P, Mosekilde, L. Reduced fracture risk in users of thiazide diuretics. Calcif. Tissue Int. 2005, 76, 167–175.

Chandler PD, Scott JB, Drake BF, et al. Risk of hypercalcemia in blacks taking hydrochlorothiazide and vitamin D. Am. J. Med. 2014, 127, 772–778.

Miller C, Damm D. Incidence of verapamil-induced gingival hyperplasia in a dental population. J. Periodontol.1992, 63, 453–456.

Tejnani A, Mani A, Sodhi NK, et al. Incidence of amlodipine-induced gingival overgrowth in the rural population of Loni. J. Indian Soc. Periodontol. 2014, 18,226–228.

Barclay S, Thomason JM, Idle JR, et al. The incidence and severity of nifedipine-induced gingival overgrowth. J. Clin. Periodontol. 1992, 19, 311–314.

Sanz M. Current use of calcium channel blockers (CCBs) is associated with an increased risk of gingival hyperplasia. J. Evid.-Based Dent. Pract. 2012, 12, 147–148.

Arya R, Gulati S, Kabra M, et al. Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children. Neurology, 2011, 76, 1338–1343.

Prasad VN, Chawla HS, Goyal A, et al. Folic acid and phenytoin induced gingival overgrowth—Is there a preventive effect. J. Indian Soc. Pedod. Prev. Dent. 2004, 22, 82–91.

Brown R, Arany P. Mechanism of drug-induced gingival overgrowth revisited: A unifying hypothesis. Oral Dis. 2015, 21, e51–e61.

Rydén M, Leanderson P, Kastbom K-O, et al. Effects of simvastatin on carotenoid status in plasma. Nutr. Metab. Cardiovasc. Dis. 2012, 22, 66–71.

Vasankari T, Ahotupa M, Viikari J, et al. Effect of 12-month statin therapy on antioxidant potential of LDL and serum antioxidant vitamin concentrations. Ann. Med. 2004, 36, 618–622

Shin M-J, Chung N, Lee JH, et al. Effects of simvastatin on plasma antioxidant status and vitamins in hypercholesterolemic patients. Int. J. Cardiol. 2007, 118, 173–177

Anagnostis P, Adamidou F, Slavakis A, et al. Comparative Effect of Atorvastatin and Rosuvastatin on 25-hydroxy-Vitamin D Levels in Non-diabetic Patients with Dyslipidaemia: A Prospective Randomized Open-label Pilot Study. Open Cardiovasc. Med. J. 2014, 8, 55–60.

Ismail F, Corder CN, Epstein S, et al. Effects of pravastatin and cholestyramine on circulating levels of parathyroid hormone and vitamin D metabolites. Clin. Ther. 1990, 12, 427–430.

Montagnani M, Loré F, Di Cairano G, et al. Effects of pravastatin treatment on vitamin D metabolites. Clin. Ther. 1994, 16, 824–829.

Ott C, Raff U, Schneider MP, et al. 25-hydroxyvitamin D insufficiency is associated with impaired renal endothelial function and both are impro-ved with rosuvastatin treatment. Clin. Res. Cardiol.2013, 102, 299–304.

Sathyapalan T, Shepherd J, Arnett C, et al. Atorvastatin increases 25-hydroxy vitamin D concentrations in patients with polycystic ovary syndrome. Clin. Chem. 2010, 56,1696–1700.

Pérez-Castrillón JL, Abad L, Vega G, et al. Effect of atorvastatin on bone mineral density in patients with acute coronary syndrome. Eur. Rev. Med.Pharmacol. Sci. 2008, 12, 83–88.

Ahmed W, Khan N, Glueck CJ, et al. Low serum 25 (OH) vitamin D levels (<32 ng/mL) are associated with reversible myositis-myalgia in statin-treated patients. Transl. Res. J. Lab. Clin. Med. 2009, 153, 11–16.

Yavuz B, Ertugrul DT, Cil H, et al. Increased levels of 25 hydroxyvitamin D and 1,25-dihydroxyvitamin D after rosuvastatin treatment: A novel pleiotropic effect of statins? Cardiovasc. Drugs Ther. 2009, 23, 295–299

Ertugrul DT, Yavuz B, Cil H, et al. STATIN-D study: Comparison of the influences of rosuvastatin and fluvastatin treatment on the levels of 25 hydroxyvitamin D. Cardiovasc. Ther. 2011, 29, 146–152.

Glossmann, H.H.; Blumthaler, M. Does rosuvastatin increase serum levels of 25-hydroxy-vitamin D? Dermato-Endocrinology 2012, 4, 2–7.

Holick, M.F. The statin D-lemma. Dermato-Endocrinology 2012, 4, 10–11.

Grimnes G, Almaas B, Eggen AE, et al. Effect of smoking on the serum levels of 25-hydroxyvitamin D depends on the assay employed. Eur. J. Endocrinol. 2010, 163, 339–348.

Yavuz B, Ertugrul DT. Statins and vitamin D. Dermato-Endocrinology, 2012, 4, 8–9.

Cangemi R, Loffredo L, Carnevale R, et al. Statins enhance circulating vitamin E. Int. J. Cardiol.2008, 123, 172–174.

Oranje WA, Sels JP, Rondas-Colbers GJ, et al. Effect of atorvastatin on LDL oxidation and antioxidants in normocholesterolemic type 2 diabetic patients. Clin. Chim. Acta. 2001, 311,91–94.

Human JA, Ubbink JB, Jerling JJ, et al. The effect of Simvastatin on the plasma antioxidant concentrations in patients with hypercholesterolaemia. Clin. Chim. Acta. 1997, 263, 67–77.

Jula A, Marniemi J, Huupponen R, et al. Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: A randomized controlled trial. JAMA, 2002, 287, 598–605

Pepping J. Coenzyme Q10. Am. J. Health. Syst. Pharm. 1999, 56, 519–521.

Folkers K, Langsjoen P, Willis R,et al. Lovastatin decreases coenzyme Q levels in humans. Proc. Natl. Acad. Sci. USA, 1990, 87, 8931–8934.

Watts GF, Castelluccio C, Rice-Evans C,et al. Plasma coenzyme Q (ubiquinone) concentrations in patients treated with simvastatin. J. Clin. Pathol. 1993, 46, 1055–1057.

Ghirlanda G, Oradei A, Manto A, et al. Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: A double-blind, placebo-controlled study. Clin. Pharmacol. 1993, 33, 226–229.

Bargossi AM, Grossi G, Fiorella PL, et al. Exogenous CoQ10 supplementation prevents plasma ubiquinone reduction induced by HMG-CoA reductase inhibitors. Mol. Asp. Med. 1994, 15, 187–193.

Mortensen SA, Leth A, Agner E, et al. Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors. Mol. Asp. Med. 1997, 18, 137–144.

Laaksonen R, Jokelainen K, Sahi T, et al. Decreases in serum ubiquinone concentrations do not result in reduced levels in muscle tissue during short-term simvastatin treatment in humans. Clin. Pharmacol. Ther. 1995, 57, 62–66.

Päivä H, Thelen KM, Van Coster R, et al. High-dose statins and skeletal muscle metabolism in humans: A randomized, controlled trial. Clin. Pharmacol. Ther. 2005, 78, 60–68

Laaksonen R, Jokelainen K, Laakso J, et al. The effect of simvastatin treatment on natural antioxidants in low-density lipoproteins and high-energy phosphates and ubiquinone in skeletal muscle. Am. J. Cardiol. 1996, 77, 851–854.

Asping M, Stride N, Søgaard D, et al. The effects of 2 weeks of statin treatment on mitochondrial respiratory capacity in middle-aged males: The LIFESTAT study. Eur. J. Clin. Pharmacol. 2017.

Lamperti C, Naini AB, Lucchini V, et al. Muscle coenzyme Q10 level in statin-related myopathy. Arch. Neurol. 2005, 62, 1709–1712.

Sacconi S, Trevisson E, Salviati L, et al. Coenzyme Q10 is frequently reduced in muscle of patients with mitochondrial myopathy. Neuromuscul. Disord. 2010, 20, 44–48.

Skarlovnik A, Jani´c M, Lunder M, et al. Coenzyme Q10 Supplementation Decreases Statin-Related Mild-to-Moderate Muscle Symptoms: A Randomized Clinical Study. Med. Sci. Monit. 2014, 20, 2183–2188.

Caso G, Kelly P, McNurlan MA, et al. Effect of coenzyme Q10 on myopathic symptoms in patients treated with statins. Am. J. Cardiol. 2007, 99, 1409–1412.

Fedacko J, Pella D, Fedackova P, et al. Coenzyme Q(10) and selenium in statin-associated myopathy treatment. Can. J. Physiol. Pharmacol. 2013, 91, 165–170.

Young JM, Florkowski CM, Molyneux SL, et al. Effect of coenzyme Q(10) supplementation on simvastatin-induced myalgia. Am. J. Cardiol. 2007, 100, 1400–1403.

Bookstaver DA, Burkhalter NA, Hatzigeorgiou C. Effect of coenzyme Q10 supplementation on statin-induced myalgias. Am. J. Cardiol. 2012, 110, 526–529.)

Ayers JJ, Cook RA, Koenig EM, et al. Recent developments in the role of coenzyme Q10 for coronary heart disease: A systematic review. Current Atherosclerosis Reports, 2018, 20(6):29. doi:10.1007/s11883-018-0730-1.

Hernandez-Camacho JD, Bernier M, Lopez-Lluch G, et al. Coenzyme Q10 supplementation in aging and disease. Frontiers in Physiology, 2018, 9:44. doi:10.3389/fphys.2018.00044.

Taylor BA. Does coenzyme Q10 supplementation mitigate Statin-Associated muscle symptoms? pharmacological and methodological considerations. American Journal of Cardiovascular Drugs, 2018, 18(2): 75–82.

Ting RZ-W, Szeto CC, Chan MH-M, et al. Risk factors of vitamin B(12) deficiency in patients receiving metformin. Arch. Intern. Med. 2006, 166, 1975–1979

Nervo M, Lubini A, Raimundo FV, et al. Vitamin B12 in metformin-treated diabetic patients: A cross-sectional study in Brazil. Rev. Assoc. Médica Bras. 2011, 57, 46–49130.

Iftikhar R, Kamran SM, Qadir A, et al. Prevalence of Vitamin B12 deficiency in patients of type 2 diabetes mellitus on metformin: A case control study from Pakistan. Pan Afr. Med. J. 2013, 16.

De Groot-Kamphuis DM, van Dijk PR, Groenier KH, et al. Vitamin B12 deficiency and the lack of its consequences in type 2 diabetes patients using metformin. Neth. J. Med. 2013, 71, 386–390.

Ko S-H, Ko S-H, Ahn Y-B, et al. Association of vitamin B12 deficiency and metformin use in patients with type 2 diabetes. J. Korean Med. Sci. 2014, 29, 965–972

Beulens JWJ, Hart HE, Kuijs R, et al. Influence of duration and dose of metformin on cobalamin deficiency in type 2 diabetes patients using metformin. Acta Diabetol. 2015, 52, 47–53.

Damião CP; Rodrigues AO, Pinheiro MFMC, et al. Prevalence of vitamin B12 deficiency in type 2 diabetic patients using metformin: A cross-sectional study. Sao Paulo Med. J. 2016, 134, 473–479.

Liu Q, Li S, Quan H, et al. Vitamin B12 status in metformin treated patients: systematic review. PLoS One, 2014 9(6):e100379. doi:10.1371/ journal.pone.0100379.).

Pflipsen MC, Oh R, Saguil A, et al. The prevalence of vitamin B (12) deficiency in patients with type 2 diabetes: A cross-sectional study. J. Am. Board Fam. Med. 2009, 22, 528–534.

Wile DJ, Toth C. Association of Metformin, Elevated Homocysteine, and Methylmalonic Acid Levels and Clinically Worsened Diabetic Peripheral Neuropathy. Diabetes Care, 2010, 33, 156–161.

SparreHermann L, Nilsson B, Wettre S. Vitamin B12 status of patients treated with metformin: A cross-sectional cohort study. Br. J. Diabetes Vasc. Dis. 2004, 4, 401–406.

Pongchaidecha M, Srikusalanukul V, Chattananon A, et al. Effect of metformin on plasma homocysteine, vitamin B12 and folic acid: A cross-sectional study in patients with type 2 diabetes mellitus. J. Med. Assoc. Thail. 2004, 87, 780–787.

Sato YK, Ouchi Y, Funase K, et al. Relationship between metformin use, vitamin B12 deficiency, hyperhomocysteinemia and vascular complications in patients with type 2 diabetes. Endocrine Journal, 2013, 60(12):1275–80.

Out MA, Kooy P, Lehert CA, et al. Long-term treatment with metformin in type 2 diabetes and methylmalonic acid: Post hoc analysis of a randomized controlled 4.3year trial. Journal of Diabetes and Its Complications, 2018, 32(2):171–8.

Gröber U, Schmidt J, Kisters K. Important drug micronutrient interactions: A selection for clinical practice, Critical Reviews in Food Science and Nutrition, 2020, 60:2, 257-275, DOI: 10.1080/10408398. 2018.1522613

Lecka-Czernik, B. Bone as a target of type 2 diabetes treatment. Curr. Opin. Investig. 2009, 10, 1085–1090.

Lecka-Czernik, B. Bone Loss in Diabetes: Use of Antidiabetic Thiazolidinediones and Secondary Osteoporosis. Curr. Osteoporos. Rep. 2010, 8, 178–184

Habib ZA, Havstad SL, Wells K, et al. Thiazolidinedione use and the longitudinal risk of fractures in patients with type 2 diabetes mellitus. J. Clin. Endocrinol. Metab. 2010, 95, 592–600.

Solomon DH, Cadarette SM, Choudhry NK, et al. A cohort study of thiazolidinediones and fractures in older adults with diabetes. J. Clin. Endocrinol. Metab. 2009, 94, 2792–2798.

Schwartz AV, Chen H, Ambrosius WT, et al. Effects of TZD Use and Discontinuation on Fracture Rates in ACCORD Bone Study. J. Clin. Endocrinol. Metab. 2015, 100, 4059–4066

Rose DP. The influence of oestrogens on tryptophan metabolism in man. Clin. Sci. 1966, 31, 265–272.

Luhby AL, Brin M, Gordon M, et al. Vitamin B6 metabolism in users of oral contraceptive agents. I. Abnormal urinary xanthurenic acid excretion and its correction by pyridoxine. Am. J. Clin. Nutr. 1971, 24, 684–693.

Donald EA, Bossé TR. The vitamin B6 requirement in oral contraceptive users. II. Assessment by tryptophan metabolites, vitamin B6, and pyridoxic acid levels in urine. Am. J. Clin. Nutr. 1979, 32, 1024–1032. 117: Price JM, Thornton MJ, Mueller LM. Tryptophan metabolism in women using steroid hormones for ovulation control. Am. J. Clin. Nutr. 1967, 20, 452–456.

Aly HE, Donald EA, Simpson MH. Oral contraceptives and vitamin B6 metabolism. Am. J. Clin. Nutr.1971, 24, 297–303.

Brown RR, Rose DP, Leklem JE, et al. Effects of oral contraceptives on tryptophan metabolism and vitamin B6 requirements in women. Acta Vitaminol. Enzymol. 1975, 29, 151–157.

Leklem JE, Brown RR, Rose DP, et al. Vitamin B6 requirements of women using oral contraceptives. Am. J. Clin. Nutr. 1975, 28, 535–541.

Lumeng L, Cleary RE, Li TK. Effect of oral contraceptives on the plasma concentration of pyridoxal phosphate. Am. J. Clin. Nutr. 1974, 27, 326–333.

Lussana F, Zighetti ML, Bucciarelli P, et al. Blood levels of homocysteine, folate, vitamin B6 and B12 in women using oral contraceptives compared to non-users. Thromb. Res. 2003, 112, 37–41.

Bossé TR, Donald EA. The vitamin B6 requirement in oral contraceptive users. I. Assessment by pyridoxal level and transferase activity in erythrocytes. Am. J. Clin. Nutr. 1979, 32, 1015–1023.

Salkeld RM, Knörr K, Körner WF. The effect of oral contraceptives on vitamin B6 status. Clin. Chim. Acta Int. J. Clin. Chem. 1973, 49, 195–199.

Vir SC, Love AH. Effect of oral contraceptives on vitamin B6 nutriture of young women. Int. J. Vitam.Nutr. Res. 1980, 50, 29–34.

Leklem JE. Vitamin B-6 requirement and oral contraceptive use—A concern? J. Nutr. 1986, 116, 475–477.

Bermond P. Therapy of side effects of oral contraceptive agents with vitamin B6. Acta Vitaminol. Enzymol. 1982, 4, 45–54.

Villegas-Salas E, Ponce de León R, Juárez-Perez MA, et al. Effect of vitamin B6 on the side effects of a low-dose combined oral contraceptive. Contraception, 1997, 55, 245–248.

Gardyn J, Mittelman M, Zlotnik J, et al. Oral contraceptives can cause falsely low vitamin B(12) levels. Acta Haematol. 2000, 104, 22–24.

Prasad AS, Lei KY, Moghissi KS, et al. Effect of oral contraceptives on nutrients. III.Vitamins B6, B12, and folic acid. Am. J. Obstet. Gynecol. 1976, 125, 1063–1069.

Briggs M, Briggs M. Vitamin C requirements and oral contraceptives. Nature, 1972, 238, 277.

McLeroy VJ, Schendel HE. Influence of oral contraceptives on ascorbic acid concentrations in healthy, sexually mature women. Am. J. Clin. Nutr. 1973, 26, 191–196.

Palmery M, Saraceno A, Vaiarelli A, et al. Oral contraceptives and changes in nutritional requirements. Eur. Rev. Med. Pharmacol. Sci. 2013, 17, 1804–1813

Pincemail J, Vanbelle S, Gaspard U, et al. Effect of different contraceptive methods on the oxidative stress status in women aged 40–48 years from the ELAN study in the province of Liege, Belgium. Hum. Reprod. 2007, 22, 2335–2343

Zal F, Mostafavi-Pour Z, Amini F, et al. Effect of vitamin E and C supplements on lipid peroxidation and GSH-dependent antioxidant enzyme status in the blood of women consuming oral contraceptives. Contraception, 2012, 86, 62–66.

Palan PR, Magneson AT, Castillo M, et al. Effects of menstrual cycle and oral contraceptive use on serum levels of lipid-soluble antioxidants. Am. J. Obstet. Gynecol. 2006, 194, e35–e38.

De Groote D; d’Hauterive SP, Pintiaux A, et al. Effects of oral contraception with ethinylestradiol and drospirenone on oxidative stress in women 18–35 years old. Contraception, 2009, 80, 187–193.

Chen J, Kotani K. Oral Contraceptive Therapy Increases Oxidative Stress in Pre-Menopausal Women. Int. J. Prev. Med. 2012, 3, 893–896.

Kowalska K, Milnerowicz H. Pro/antioxidant status in young healthy women using oral contraceptives. Environ. Toxicol. Pharmacol. 2016, 43, 1–6.

Cauci S, Buligan C, Marangone M, et al. Oxidative Stress in Female Athletes Using Combined Oral Contraceptives. Sports Med. Open 2016, 2, 40.

De Vries F, Pouwels S, Bracke M, et al. Use of beta-2 agonists and risk of hip/femur fracture: A population-based case-control study. Pharmacoepidemiol. Drug Saf. 2007, 16, 612–619.

Tattersfield AE, Town GI, Johnell O, et al. Bone mineral density in subjects withmild asthma randomised to treatment with inhaled corticosteroids or non-corticosteroid treatment for two years. Thorax, 2001, 56, 272–278.

Richy F, Bousquet J, Ehrlich GE, et al. Inhaled corticosteroids effects on bone in asthmatic and COPD patients: A quantitative systematic review. Osteoporos. Int. 2003, 14, 179–190.

Jones A, Fay JK, Burr M, et al. Inhaled corticosteroid effects on bone metabolism in asthma and mild chronic obstructive pulmonary disease. Cochrane Database Syst. Rev. 2002, CD003537

Loke LK, Gilbert D, Thavarajah M, et al. Bone mineral density and fracture risk with long-term use of inhaled corticosteroids in patients with asthma:Systematic review and meta-analysis.BMJOpen, 2015, 5, e008554.

van Orten-Luiten AC, Janse A, Dhonukshe-Rutten RA, et al. Vitamin D deficiency as adverse drug reaction? A cross-sectional study in Dutch geriatric outpatients. Eur J Clin Pharmacol. 2016;72(5):605–614.

Verhoeven V, Vanpuyenbroeck K, Lopez-Hartmann M, et al. Walk on the sunny side of life–epidemiology of hypovitaminosis D and mental health in elderly nursing home residents. J Nutr Health Aging. 2012;16(4):417–420.

Rizzoli R, Cooper C, Reginster YJ, et al. Antidepressant medications and osteoporosis. Bone, 2012, 51, 606–613.

Eom C-S, Lee H-K, Ye S, et al. Use of selective serotonin reuptake inhibitors and risk of fracture: A systematic review and meta-analysis. J. Bone Miner. Res. 2012, 27, 1186–1195.

Panday K, Gona A, Humphrey MB. Medication-induced osteoporosis: Screening and treatment strategies. Ther. Adv. Musculoskelet. Dis. 2014, 6, 185–202.

Tsapakis EM, Gamie Z, Tran GT, et al. The adverse skeletal effects of selective serotonin reuptake inhibitors. Eur. Psychiatry, 2012, 27, 156–169.

Parsons C, Johnston S, Mathie E, et al. Potentially inappropriate prescribing in older people with dementia in care homes: A retrospective analysis. Drugs Aging, 2012. 29(2):143–55.

Zhang X, Zhou S, Pan K, et al. Potentially inappropriate medications in hospitalized older patients: A cross-sectional study using the beers 2015 criteria versus the 2012 criteria. Clinical Interventions in Aging, 2017, 12:1697–703. doi:10.2147/CIA.S146009. eCollection 2017.

Boucherie Q, Rouby F, Frankel D, et al. Proton pump inhibitors prescriptions in France: Main trends from 2006 to 2016 on French health insurance database. Therapie, 2018. pii: S0040-5957(18)30044-1. doi:10.1016/j.therap.2018.03.001.)

Ito, T, and Jensen RT. 2010. Association of long-term proton pump inhibitor therapy with bone fractures and effects on absorption of calcium, vitamin B12, iron, and magnesium. Current Gastroenterology Reports, 2010, 12(6):448–57.

Tang G, Serfaty-Lacrosniere C, Camilo ME, et al. Gastric acidity influences the blood response to a beta-carotene dose in humans. Am. J. Clin. Nutr. 1996, 64, 622–626.

Valuck RJ, Ruscin JM. A case-control study on adverse effects: H2 blocker or proton pump inhibitor use and risk of vitamin B12 deficiency in older adults. J. Clin. Epidemiol. 2004, 57, 422–428.

Dharmarajan TS, Kanagala MR, Murakonda P, et al. Do acid-lowering agents affect vitamin B12 status in older adults? J. Am. Med. Dir. Assoc. 2008, 9, 162–167

Schenk BE, Kuipers EJ, Klinkenberg-Knol EC, et al. Atrophic gastritis during long-term omeprazole therapy affects serum vitamin B12 levels. Aliment. Pharmacol. Ther. 1999, 13, 1343–1346

Schenk BE, Festen HP, Kuipers EJ, et al. Effect of short- and long-term treatment with omeprazole on the absorption and serum levels of cobalamin. Aliment. Pharmacol. Ther. 1996, 10, 541–545.

Lam JR, Schneider JL, Zhao W, et al. Proton pump inhibitor and histamine 2 receptor antagonist use and vitamin B12 deficiency. JAMA, 2013, 310(22):2435–42.

Pennypacker LC, Allen RH, Kelly JP, et al. High prevalence of cobalamin deficiency in elderly outpatients. J. Am. Geriatr. Soc. 1992, 40, 1197–1204.

Sagar M, Janczewska I, Ljungdahl A, et al. Effect of CYP2C19 polymorphism on serum levels of vitamin B12 in patients on long-term omeprazole treatment. Aliment. Pharmacol. Ther. 1999, 13, 453–458.

Furuta T, Shirai N, Sugimoto M, et al. Influence of CYP2C19 Pharmacogenetic Polymorphism on Proton Pump Inhibitor-based Therapies. Drug Metab. Pharmacokinet. 2005, 20, 153–167.

Kittang E, Aadland E, Schjønsby H. Effect of omeprazole on the secretion of intrinsic factor, gastric acid and pepsin in man. Gut, 1985, 26, 594–598.

Saltzman JR, Kemp JA, Golner BB, et al. Effect of hypochlorhydria due to omeprazole treatment or atrophic gastritis on protein-bound vitamin B12 absorption. J. Am. Coll. Nutr. 1994, 13, 584–591.

McColl KEL. Effect of proton pump inhibitors on vitamins and iron. Am. J. Gastroenterol. 2009, 104 (Suppl. S2), S5–S9.

Mowat C, Williams C, Gillen D, et al. Omeprazole, Helicobacter pylori status, and alterations in the intragastric milieu facilitating bacterial N-nitrosation. Gastroenterology, 2000, 119, 339–347.

Woodward M, Tunstall-Pedoe H, McColl K. Helicobacter pylori infection reduces systemic availability of dietary vitamin C. Eur. J. Gastroenterol. Hepatol. 2001, 13, 233–237.

Mowat C, Carswell A, Wirz A, et al. Omeprazole and dietary nitrate independently affect levels of vitamin C and nitrite in gastric juice. Gastroenterology, 1999, 116, 813–822.

Henry EB, Carswell A, Wirz A, et al. Proton pump inhibitors reduce the bioavailability of dietary vitamin C. Aliment. Pharmacol. Ther. 2005, 22, 539–545.

Qato DM, Wilder J, Schumm LP, et al. Changes in Prescription and Over-the-Counter Medication andDietary Supplement Use Among Older Adults in the United States, 2005 vs. 2011. JAMA Intern. Med. 2016, 176, 473–482.

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