Baş Ağrısı, Migren ve Epilepsi İlişkisi

Yazarlar

Nesibe Gevher Eroğlu Ertuğrul
https://orcid.org/0000-0003-4995-8992

Özet

Migren ve epilepsi, ortak klinik bulgulara ve genetik temellere sahip, birbirleriyle karmaşık bir ilişki içinde olan paroksismal nörolojik bozukluklardır. Klinik pratikte sıkça bir arada görülebilen bu durumlar, görsel aura benzerliği veya migren aurasıyla tetiklenen nöbetler gibi ortak "sınır bölgeleri" oluşturur. Antiepileptik ilaçlar, her iki durumun ortak patogenetik mekanizmalarını hedef alarak migren profilaksisinde etkin rol oynamaktadır; ancak kesin tanı için detaylı nörolojik değerlendirme ve bazen EEG monitörizasyonu kritik önem taşır.

 

Migraine and epilepsy are paroxysmal neurological disorders that share common clinical findings, genetic foundations, and complex interrelations. Frequently co-occurring in clinical practice, these conditions form "borderlands," characterized by overlapping features like visual aura similarities or seizures triggered by migraine aura. Antiepileptic drugs play an effective role in migraine prophylaxis by targeting shared pathogenetic mechanisms, although precise diagnosis often requires thorough neurological evaluation and, in select cases, EEG monitoring.

Referanslar

Hershey AD, Kabbouche MA, O’Brien HL, Kacperski J. Headaches. Kliegman RM, ST Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM (eds). Nelson Textbook of Pediatrics. 21. Ed. Philadelphia: Elsevier; 2020. p.3128-3140

Kabbouche MA, Kacperski J, O’Brien HL, Powers SW, Hershey AD. Headache in Children and Adolescents. Swaiman KF, Ashwal S, Ferriero DM (eds). Swaiman’s Pediatric Neurology. 6. Ed. Edinburgh: Elsevier; 2018. p.2462-2476.

Lewis D, Ashwal S, Hershey A, Hirtz D, Yonker M, Silberstein S, American Academy of Neurology Quality Standards Subcommittee, & Practice Committee of the Child Neurology Society. Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society. Neurology, 2004;63(12):2215–2224.

Demarquay G, Rheims S. Relationships between migraine and epilepsy: Pathophysiological mechanisms and clinical implications. Revue neurologique, 2021;177(7):791–800.

Garg D, Tripathi M. Borderlands of Migraine and Epilepsy. Neurol India 2021;69:91-7.

Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia 2018;38:1-211.

Cianchetti C, Avanzini G, Dainese F, Guidetti V. The complex interrelations between two paroxysmal disorders: Headache and epilepsy. Neurol Sci 2017;38:941-8.

Panayiotopoulos CP. “Migralepsy” and the significance of differentiating occipital seizures from migraine. Epilepsia 2006;47:806-8.

Fisher RS, Cross JH, D’Souza C, French JA, Haut SR, Higurashi N, et al. Instruction manual for the ILAE 2017 operational classification of seizure types. Epilepsia 2017;58:531–42. http://doi.org/10.1111/epi.13671.

Cianchetti C, Dainese F, Ledda MG, Avanzini G. Epileptic headache: a rare form of painful seizure. Seizure 2017;52:169–75.

Ekstein D, Schachter SC. post-ictal headache. Epilepsy Behav 2010;19:151 5.

Nunes JC, Zakon DB, Claudino LS, Guarnieri R, Bastos A, Queiroz LP, et al. Hippocampal sclerosis and ipsilateral headache among mesial temporal lobe epilepsy patients. Seizure 2011;20:480–4.

Bernasconi A, Andermann F, Bernasconi N, Reutens DC, Dubeau F. Lateralizing value of peri-ictal headache: A study of 100 patients with partial epilepsy. Neurology 2001;56:130–2.

AlKhaja M, Alhowity I, Alotaibi F, Khoja A, Alsumaili M, Alsulami A, et al. Lateralization value of peri-ictal headache in drug-resistant focal epilepsy. Epilepsy Behav 2021;116:107712.

Palmini A, Gloor P. The localizing value of auras in partial seizures: a prospective and retrospective study. Neurology 1992;42:801–8.

Dainese F, Mai R, Francione S, Mainardi F, Zanchin G, Paladin F. Ictal headache: headache as first ictal symptom in focal epilepsy. Epilepsy Behav 2011;22:790–2.

Belcastro V, Striano P, Pierguidi L, Calabresi P, Tambasco N. Ictal epileptic headache mimicking status migrainosus: EEG and DWI-MRI findings. Headache 2011;51:160–2.

Ito M, Adachi N, Nakamura F, Koyama T, Okamura T, Kato M, et al. Multi-center study on post-ictal headache in patients with localization-related epilepsy. Psychiatry Clin Neurosci 2003;57:385–9.

Graham J, Wolff H. Mechanism of migraine headache and action of ergotamine tartrate. Arch Neurol Psychiatry 1938;39:737–63.

Ashina M, Hansen JM, Do TP, Melo-Carrillo A, Burstein R, Moskowitz MA. Migraine and the trigeminovascular system-40 years and counting. Lancet Neurol 2019;18:795– 804.

Penfield WBE. Somatic motor and sensory representations in the cerebral cortex of man as studied by electrical stimulation. Brain 1937;60(4):389–443.

Hotolean E, Mazzola L, Rheims S, Isnard J, Montavont A, Catenoix H, et al. Headaches provoked by cortical stimulation: Their localizing value in focal epileptic seizures. Epilepsy Behav 2021;122:108125.

Russell MB, Ducros A. Sporadic and familial hemiplegic migraine: pathophysiological mechanisms, clinical characteristics, diagnosis, and management. Lancet Neurol 2011;10:457–70.

Gardiner AR, Bhatia KP, Stamelou M, Dale RC, Kurian MA, Schneider SA, et al. PRRT2 gene mutations: From paroxysmal dyskinesia to episodic ataxia and hemiplegic migraine. Neurology 2012;79:2115-21.

Hasirci Bayir BR, Tutkavul K, Eser M, Baykan B. Epilepsy in patients with familial hemiplegic migraine. Seizure 2021;88:87–94.

Cevoli S, Pallotti F, La Morgia C, Valentino ML, Pierangeli G, Cortelli P, et al. High frequency of migraine-only patients negative for the 3243 A>G tRNALeu mtDNA mutation in two MELAS families. Cephalalgia 2010;30:919-27.

Planche V, Chassin O, Leduc L, Regnier W, Kelly A, Colamarino R. Sturge-Weber syndrome with late onset hemiplegic migraine-like attacks and progressive unilateral cerebral atrophy. Cephalalgia 2014;34:73-7.

Viana M, Sances G, Linde M, Nappi G, Khaliq F, Goadsby PJ, et al. Prolonged migraine aura: new insights from a prospective diary-aided study. J Headache Pain 2018;19:77.

Hartl E, Gonzalez-Victores JA, Re ́mi J, Schankin CJ, Noachtar S. Visual auras in epilepsy and migraine - an analysis of clinical characteristics. Headache 2017;57:908– 16.

Hansen JM, Baca SM, Vanvalkenburgh P, Charles A. Distinctive anatomical and physiological features of migraine aura revealed by 18 years of recording. Brain 2013;136:3589–95.

Panayiotopoulos CP. Elementary visual hallucinations, blindness, and headache in idiopathic occipital epilepsy: differentiation from migraine. J Neurol Neurosurg Psychiatry 1999;66:536–40.

Hartl E, Gonzalez-Victores JA, Re ́mi J, Schankin CJ, Noachtar S. Visual auras in epilepsy and migraine - an analysis of clinical characteristics. Headache 2017;57:908– 16.

Sørensen KV. Valproate: a new drug in migraine prophylaxis. Acta Neurol Scand 1988;78:346–8.

Jensen R, Brinck T, Olesen J. Sodium valproate has a prophylactic effect in migraine without aura: a triple-blind, placebo-controlled crossover study. Neurology 1994;44:647– 51.

Diener H-C, Bussone G, Van Oene JC, Lahaye M, Schwalen S, Goadsby PJ, et al. Topiramate reduces headache days in chronic migraine: a randomized, double-blind, placebo- controlled study. Cephalalgia 2007;27:814–23.

Jackson JL, Cogbill E, Santana-Davila R, Eldredge C, Collier W, Gradall A, et al. A Comparative Effectiveness Meta- Analysis of Drugs for the Prophylaxis of Migraine Headache. PLoS One 2015;10:e0130733.

Romoli M, Costa C, Siliquini S, Corbelli I, Eusebi P, Bedetti C, et al. Antiepileptic drugs in migraine and epilepsy: who is at increased risk of adverse events? Cephalalgia 2018;38:274–82.

Kashipazha D, Ghadikolaei HS, Siavashi M. Levetiracetam in Compare to Sodium Valproate for Prophylaxis in Chronic Migraine Headache: A Randomized

Double-Blind Clinical Trial. Curr Clin Pharmacol 2017;12:55–9.

Buch D, Chabriat H. Lamotrigine in the Prevention of Migraine With Aura: A Narrative Review. Headache 2019;59:1187–97.

Biton V, Shneker BF, Naritoku D, Hammer AE, Vuong A, Caldwell PT, et al. Long-term tolerability and safety of lamotrigine extended-release: pooled analysis of three clinical trials. Clin Drug Investig 2013;33:359–64.

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18 Ocak 2023

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