Epilepsinin Etiyolojisi ve Risk Faktörleri
Özet
Epilepsinin etiyolojisi; yapısal, genetik, enfeksiyöz, metabolik, immün ve bilinmeyen olmak üzere altı ana başlıkta sınıflandırılır ve bu sınıflandırma hastaların tanı, tedavi ve prognoz yönetiminde kritik bir rol oynar. Genetik yatkınlık, kafa travmaları, merkezi sinir sistemi enfeksiyonları ve febril nöbetler gibi faktörler epilepsi gelişimi için önemli risk oluşturmaktadır. Tedavi sürecinde hedefe yönelik yaklaşım ve hassas tıp uygulamaları, etiyolojik nedenlerin doğru belirlenmesiyle mümkün olmaktadır.
Epilepsy etiology is categorized under six main groups—structural, genetic, infectious, metabolic, immune, and unknown—which serve as a critical guide for diagnosis, treatment, and prognosis management. Factors such as genetic predisposition, head trauma, central nervous system infections, and febrile seizures pose significant risks for the development of epilepsy. Targeted treatment approaches and precision medicine applications in the clinical process depend heavily on the accurate identification of these underlying etiological causes.
Referanslar
Scheffer IE, Berkovic S, Capovilla G, Connolly MB, French J, Guilhoto L, Hirsch E, Jain S, Mathern GW, Moshé SL, Nordli DR. ILAE classification of the epilepsies: position paper of the ILAE Commission for Classification and Terminology. Epilepsia. 2017 Apr;58(4):512-21.
Varnado S, Price D. Basics of modern epilepsy classification and terminology. Current Problems in Pediatric and Adolescent Health Care. 2020 Nov 1;50(11):100891.
Balestrini S, Arzimanoglou A, Blümcke I, Scheffer IE, Wiebe S, Zelano J, Walker MC. The aetiologies of epilepsy. Epileptic Disorders. 2021 Feb;23(1):1-6.
Shorvon SD. A history of neuroimaging in epilepsy 1909–2009. Epilepsia. 2009 Mar;50:39-49.
Bernasconi N, Wang I. Emerging trends in neuroimaging of epilepsy. Epilepsy Currents. 2021 Mar;21(2):79-82.
Rosenow F, Akamatsu N, Bast T, Bauer S, Baumgartner C, Benbadis S, Bermeo-Ovalle A, Beyenburg S, Bleasel A, Bozorgi A, Brázdil M. Could the 2017 ILAE and the four-dimensional epilepsy classifications be merged to a new “Integrated Epilepsy Classification”?. Seizure. 2020 May 1;78:31-7.
Blümcke I, Thom M, Aronica E, Armstrong DD, Bartolomei F, Bernasconi A, Bernasconi N, Bien CG, Cendes F, Coras R, Cross JH. International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: a Task Force report from the ILAE Commission on Diagnostic Methods. Epilepsia. 2013 Jul;54(7):1315-29.
Malmgren K, Thom M. Hippocampal sclerosis—origins and imaging. Epilepsia. 2012 Sep;53:19-33.
van Breemen MS, Wilms EB, Vecht CJ. Epilepsy in patients with brain tumours: epidemiology, mechanisms, and management. The Lancet Neurology. 2007 May 1;6(5):421-30.
de Groot M, Reijneveld JC, Aronica E, Heimans JJ. Epilepsy in patients with a brain tumour: focal epilepsy requires focused treatment. Brain. 2012 Apr 1;135(4):1002-16.
D'Ambrosio R, Perucca E. Epilepsy after head injury. Current opinion in neurology. 2004 Dec;17(6):731.
Tubi MA, Lutkenhoff E, Blanco MB, McArthur D, Villablanca P, Ellingson B, Diaz-Arrastia R, Van Ness P, Real C, Shrestha V, Engel Jr J. Early seizures and temporal lobe trauma predict post-traumatic epilepsy: a longitudinal study. Neurobiology of disease. 2019 Mar 1;123:115-21.
Ferguson PL, Smith GM, Wannamaker BB, Thurman DJ, Pickelsimer EE, Selassie AW. A population‐based study of risk of epilepsy after hospitalization for traumatic brain injury. Epilepsia. 2010 May;51(5):891-8.
Hilgetag CC, Barbas H. Role of mechanical factors in the morphology of the primate cerebral cortex. PLoS computational biology. 2006 Mar;2(3):e22.
Leventer RJ, Guerrini R, Dobyns WB. Malformations of cortical development and epilepsy. Dialogues in clinical neuroscience. 2008 Mar;10(1):47.
Higueros E, Roe E, Granell E, Baselga E. Sturge-Weber syndrome: a review. Actas Dermo-Sifiliográficas (English Edition). 2017 Jun 1;108(5):407-17.
Chiaretti A, De Benedictis R, Polidori G, Piastra M, Iannelli A, Di Rocco C. Early post-traumatic seizures in children with head injury. Child's Nervous System. 2000 Dec;16(12):862-6.
Sundelin HE, Tomson T, Zelano J, Söderling J, Bang P, Ludvigsson JF. Pediatric Ischemic Stroke and Epilepsy: A Nationwide Cohort Study. Stroke. 2021 Nov;52(11):3532-40.
Akar N, Dönmez B, Deda G. FXIII gene Val34Leu polymorphism in Turkish children with cerebral infarct. Journal of child neurology. 2007 Feb;22(2):222-4.
Zhao Y, Li X, Zhang K, Tong T, Cui R. The progress of epilepsy after stroke. Current Neuropharmacology. 2018 Jan 1;16(1):71-8.
Bhalla D, Godet B, Druet-Cabanac M, Preux PM. Etiologies of epilepsy: a comprehensive review. Expert review of neurotherapeutics. 2011 Jun 1;11(6):861-76.
Striano P, Minassian BA. From genetic testing to precision medicine in epilepsy. Neurotherapeutics. 2020 Apr;17(2):609-15.
Perucca P, Bahlo M, Berkovic SF. The genetics of epilepsy. Annual review of genomics and human genetics. 2020 Aug 31;21:205-30.
Rahman MM, Fatema K. Genetic Diagnosis in Children with Epilepsy and Developmental Disorders by Targeted Gene Panel Analysis in a Developing Country. Journal of Epilepsy Research. 2021 Jun;11(1):22.
Murthy JM, Prabhakar S. Bacterial meningitis and epilepsy. Epilepsia. 2008 Aug;49:8-12.
Da Silva LF, Nunes ML, Da Costa JC. Risk factors for developing epilepsy after neonatal seizures. Pediatric neurology. 2004 Apr 1;30(4):271-7.
Zainel A, Mitchell H, Sadarangani M. Bacterial meningitis in children: neurological complications, associated risk factors, and prevention. Microorganisms. 2021 Mar;9(3):535.
Chuang MJ, Chang WN, Chang HW, Lin WC, Tsai NW, Hsieh MJ, Wang HC, Lu CH. Predictors and long-term outcome of seizures after bacterial brain abscess. Journal of Neurology, Neurosurgery & Psychiatry. 2010 Aug 1;81(8):913-7.
Misra UK, Tan CT, Kalita J. Viral encephalitis and epilepsy. Epilepsia. 2008 Aug;49:13-8.
Reddy C, Saini AG. Metabolic epilepsy. Indian Journal of Pediatrics. 2021 Oct;88(10):1025-32.
Sharma S, Prasad AN. Inborn errors of metabolism and epilepsy: current understanding, diagnosis, and treatment approaches. International journal of molecular sciences. 2017 Jul;18(7):1384.
Papetti L, Parisi P, Leuzzi V, Nardecchia F, Nicita F, Ursitti F, Marra F, Paolino MC, Spalice A. Metabolic epilepsy: an update. Brain and Development. 2013 Oct 1;35(9):827-41.
Vezzani A, French J, Bartfai T, Baram TZ. The role of inflammation in epilepsy. Nature reviews neurology. 2011 Jan;7(1):31-40.
Husari K, Dubey D. Autoimmune epilepsy. Neuroimmunology. 2021:189-206.
Asadi-Pooya AA, Hojabri K. Risk factors for childhood epilepsy: a case–control study. Epilepsy & Behavior. 2005 Mar 1;6(2):203-6.
Daoud AS, Batieha A, Bashtawi M, El-Shanti H. Risk factors for childhood epilepsy: a case-control study from Irbid, Jordan. Seizure. 2003 Apr 1;12(3):171-4.
Hauser WA. Risk factors for epilepsy. InThe Epilepsies 1999 Jan 1 (pp. 1-11). Academic Press.
Patel N, Ram D, Swiderska N, Mewasingh LD, Newton RW, Offringa M. Febrile seizures. Bmj. 2015 Aug 18;351.
Vestergaard M, Pedersen CB, Sidenius P, Olsen J, Christensen J. The long-term risk of epilepsy after febrile seizures in susceptible subgroups. American journal of epidemiology. 2007 Apr 15;165(8):911-8.
Ziobro J, Shellhaas RA. Neonatal seizures: diagnosis, etiologies, and management. InSeminars in Neurology 2020 Apr (Vol. 40, No. 02, pp. 246-256). Thieme Medical Publishers.
Canpolat M, Kumandas S, Poyrazoglu HG, Gumus H, Elmali F, Per H. Prevalence and risk factors of epilepsy among school children in Kayseri City Center, an urban area in Central Anatolia, Turkey. Seizure. 2014 Oct 1;23(9):708-16.
Hesdorffer DC, Tian H, Anand K, Hauser WA, Ludvigsson P, Olafsson E, Kjartansson O. Socioeconomic status is a risk factor for epilepsy in Icelandic adults but not in children. Epilepsia. 2005 Aug;46(8):1297-303.
