Febril Nöbetler
Özet
Febril nöbetler, genellikle 6 ay ile 5 yaş arasındaki çocuklarda 38°C'den yüksek ateşle seyreden, altta yatan ciddi bir enfeksiyon veya nörolojik bozukluk olmaksızın gelişen en sık nörolojik tablodur. Nöbetler basit, kompleks veya febril status epileptikus olarak sınıflandırılmakta olup, teşhis ve tedavi süreci klinik bulgulara göre bireyselleştirilmelidir. Genellikle iyi huylu bir seyir izleseler de, kompleks nöbet geçiren veya altta yatan risk faktörlerine sahip çocuklarda ileride epilepsi gelişme riski daha yüksektir. Tedavi yaklaşımı akut nöbet yönetimine ve aile eğitimine dayanmakta olup, profilaktik ilaç kullanımı yalnızca belirli risk durumlarında önerilmektedir.
Referanslar
Leung A , Hon KL, Leung T. Febrile seizures: an overview. Drugs Context.2018 ;16;7:212536
Leung AK, Robson WL. Febrile seizures. J Pediatr Health Care. 2007;21:250–255
Steering Committee on Quality Improvement and Management, Subcommittee on Febrile Seizures American Academy of Pediatrics. Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics. 2008;121:1281–1286.
Natsume J, Hamano SI, Iyoda K, et al. New guidelines for management of febrile seizures in Japan. Brain Dev. 2017;39:2–9.
Subcommittee on Febrile Seizures; American Academy of Pediatrics. Neurodiagnostic evaluation of the child with a simple febrile seizure. Pediatrics. 2011;127:389–394
Canpolat M, Per H, Gumus H, Elmali F, Kumandas S. Investigating the prevalence of febrile convulsion in Kayseri, Turkey: an assessment of the risk factors for recurrence of febrile convulsion and for development of epilepsy. Seizure. 2018;55:36–47
Paul SP, Seymour M, Flower D, Rogers E. Febrile convulsions in children. Nurs Child Young People. 2015;27:14–15.
Sharawat IK, Singh J, Dawman L, Singh A. Evaluation of risk factors associated with first episode febrile seizure. J Clin Diagn Res. 2016;10:10–13.
Canpolat M, Kumadaş S.Febril konvülziyon.Kumandaş S,Canpolat M,editörler.Çocukluk Çağı Epilepsileri.1.Baskı.Ankara:Türkiye Klinikleri ;2020.p.72-90.
Seinfeld S, Shinnar S. Febrile Seizures. Swaiman KF, Aswal S, Ferriero DM, eds. Swaiman’s Pediatric neurology. Principles and Practice. (6th Ed). Elsevier Saunders, UK/USA. 2017. p.519-23. 2.
Seinfeld S, Glauser Ta, Shinnar S. Febrile Seizures. Pellock jm, nordli DR, Sankar R, Wheless jW, eds. Pellock’s Petiatric Epilepsy. fourth Ed, new York: Demos medical Publishing. 2017.p.505-16.
Veisani Y, Delpisheh A, Sayehmiri K. Familial history and recurrence of febrile seizures; a systematic review and meta-analysis. Iran J Pediatr. 2013;23:389–395.
Sadleir LG, Scheffer IE. Febrile seizures. BMJ. 2007;334(7588):307–311.
Fetveit A. Assessment of febrile seizures in children. Eur J Pediatr. 2008;167:17–27
Kim K, Kwak BO, Kwon A, et al. Analysis of plasma multiplex cytokines and increased level of IL-10 and IL-1Ra cytokines in febrile seizures. J Neuroinflammation. 2017;14:200
Patterson JL, Carapetian SA, Hageman JR, Kelley KR. Febrile seizures. Pediatr Ann. 2013;42:249–254.
Babl FE, Lewena S, Brown L. Vaccination-related adverse events. Pediatr Emerg Care. 2006;22:514–519
Duffy J, Weintraub E, Hambidge SJ, et al. Vaccine Safety Datalink. Febrile seizure risk after vaccination in children 6 to 23 months. Pediatrics. 2016;138(1)
Duffy J, Hambidge SJ, Jackson LA, et al. Vaccine Safety Datalink. Febrile seizure risk after vaccination in children one to five months of age. Pediatr Neurol. 2017;76:72–78.
Camfield P, Camfield C. Febrile seizures and genetic epilepsy with febrile seizures plus (GEFS+) Epileptic Disord. 2015;17(2):124–133
Tu YF, Wang LW, Wang ST, Yeh TF, Huang CC. Postnatal steroids and febrile seizure susceptibility in preterm children. Pediatrics. 2016;137(4)
Vestergaard M, Wisborg K, Henriksen TB, Secher NJ, Ostergaard JR, Olsen J. Prenatal exposure to cigarettes, alcohol, and coffee and the risk for febrile seizures. Pediatrics. 2005;116:1089–1094.
Gholipoor P, Saboory E, Ghazavi A, et al. Prenatal stress potentiates febrile seizure and leads to long-lasting increase in cortisol blood levels in children under 2 years old. Epilepsy Behav. 2017;72:22–27.
Thébault-Dagher F, Herba CM, Séguin JR, et al. Age at first febrile seizure correlates with perinatal maternal emotional symptoms. Epilepsy Res. 2017;135:95–101.
Hjortebjerg D, Nybo Andersen AM, Ketzel M, Raaschou-Nielsen O, Sørensen M. Exposure to traffic noise and air pollution and risk for febrile seizure: a cohort study. Scand J Work Environ Health. 2018
Aziz KT, Ahmed N, Nagi AG. Iron deficiency anaemia as risk factor for simple febrile seizures: a case control study. J Ayub Med Coll Abbottabad. 2017;29:316–319.
Habibian N, Alipour A, Rezaianzadeh A. Association between iron deficiency anemia and febrile convulsion in 3- to 60-month-old children: a systematic review and meta-analysis. Iran J Med Sci. 2014;39:496–505
Namakin K, Zardast M, Sharifzadeh G, Bidar T, Zargarian S. Serum trace elements in febrile seizure: a case-control study. Iran J Child Neurol. 2016;10:57–60.
Nasehi MM, Sakhaei R, Moosazadeh M, Aliramzany M. Comparison of serum zinc levels among children with simple febrile seizure and control group: a systematic review. Iran J Child Neurol. 2015;9(1):17–24.
Saghazadeh A, Mahmoudi M, Meysamie A, Gharedaghi M, Zamponi GW, Rezaei N. Possible role of trace elements in epilepsy and febrile seizures: a meta-analysis. Nutr Rev. 2015;73:760–779. 28- Özkale Y, Erol İ, Kılıçarslan B, et al. Serum vitamin B12, folic acid, and homocysteine levels in children with febrile seizure. Turk J Pediatr. 2015;57:345–352
Patel N, Ram D, Swiderska N, Mewasingh LD, Newton RW, Offringa M. Febrile seizures. BMJ. 2015;351:h4240
Paul SP, Kirkham EN, Shirt B. Recognition and management of febrile convulsion in children. Nurs Stand. 2015;29:36–43
Hon KL, Leung AK, Torres AR. Febrile infection-related epilepsy syndrome (FIRES): an overview of treatment and recent patents. Recent Pat Endocr Metab Immune Drug Discov. 2018
Pappano D, Osborne M. Febrile myoclonus. Pediatr Emerg Care. 2007;23:649–650
Miller PM, Srouk Y, Watemberg N. Febrile myoclonus: an underreported, benign condition in infancy often misinterpreted as febrile seizures. Pediatr Emerg Care. 2008;24:618–620.
Scheffer IE, Berkovic SF. Generalized epilepsy with febrile seizures plus. A genetic disorder with heterogeneous clinical phenotypes. Brain. 1997;120:479–490.
Zhang YH, Burgess R, Malone JP, et al. Genetic epilepsy with febrile seizures plus: refining the spectrum. Neurology. 2017;89:1210–1219
Wallace RH, Scheffer IE, Barnett S, et al. Neuronal sodium-channel alpha1-subunit mutations in generalized epilepsy with febrile seizures plus. Am J Hum Genet. 2001;68:859–865.
Hirsch LJ, Gaspard N, van Baalen A, et al. Proposed consensus definitions for new-onset refractory status epilepticus (NORSE), febrile infection-related epilepsy syndrome (FIRES), and related conditions. Epilepsia. 2018;59:739–744
Dravet C. Severe myoclonic Epilpesy of ınfancy. Duchowny m, Cross j.H, arzimanoglu a (Eds.) Pediatric Epilepsy. mc graw Hill medical, Printed in China (Except as permitted under the United States Copyright act of 1976). 2013;99-111
Teran CG, Medows M, Wong SH, Rodriguez L, Varghese R. Febrile seizures: current role of the laboratory investigation and source of the fever in the diagnostic approach. Pediatr Emerg Care. 2012;28:493–497
Cuestas E. Is routine EEG helpful in the management of complex febrile seizures ? Arch Dis Child. 2004;89:290
Capovilla G, Mastrangelo M, Romeo A, Vigevano F. Recommendations for the management of “febrile seizures”: Ad Hoc Task Force of LICE Guidelines Commission. Epilepsia. 2009;50:2–6.
Lee SH, Byeon JH, Kim GH, Eun BL, Eun SH. Epilepsy in children with a history of febrile seizures. Korean J Pediatr. 2016;59:74–79.
Pujar SS, Seunarine KK, Martinos MM, et al. Long-term white matter tract reorganization following prolonged febrile seizures. Epilepsia 2017;58:772–780
Yu YH, Lee K, Sin DS, Park KH, Park DK, Kim DS. Altered functional efficacy of hippocampal interneuron during epileptogenesis following febrile seizures. Brain Res Bull. 2017;131:25–38.
Beker-Acay M, Köken R, Ünlü E, Kaçar E, Balçık Ç. Evaluation of hippocampal infolding angle and incomplete hippocampal inversion in pediatric patients with epilepsy and febrile seizures. Diagn Interv Radiol. 2017;23:326–330
Salehi B, Yousefichaijan P, Safi Arian S, Ebrahimi S, Naziri M. Comparison of relation between attention deficit hyperactivity disorder in children with and without simple febrile seizure admitted in Arak Central Iran. Iran J Child Neurol. 2016;10:56–61
Tu YF, Lin CL, Lin CH, Huang CC, Sung FC, Kao CH. Febrile convulsions increase risk of Tourette syndrome. Seizure. 2014;23:651–656.
Lin WY, Muo CH, Ku YC, Sung FC, Kao CH. Increased association between febrile convulsion and allergic rhinitis in children: a nationwide population-based retrospective cohort study. Pediatr Neurol. 2014;50:329–333.
Tasaka K, Matsubara K, Hori M, et al. Neurogenic pulmonary edema combined with febrile seizures in early childhood-A report of two cases. IDCases. 2016;6:90–93.
Myers KA, McPherson RE, Clegg R, Buchhalter J. Sudden death after febrile seizure case report: cerebral suppression precedes severe bradycardia. Pediatrics. 2017;140(5).
Seinfeld S, Shinnar S, Sun S, et al. FEBSTAT study team. Emergency management of febrile status epilepticus: results of the FEBSTAT study. Epilepsia. 2014;55:388–395.
Capovilla G, Mastrangelo M, Romeo A, Vigevano F. Recommendations for the management of "febrile seizures": ad Hoc Task force of lıCE guidelines Commission. Epilepsia. 2009;50(1):2-6.
Yakut A. Febril Konvülziyon. Yalaz K, ed. Temel gelişimsel Çocuk nörolojisi. genişletilmiş 2. Baskı. Hipokrat Kitabevi, ankara. 2018.p.201-9.
Hu L-Y, Shi X-Y, Li H, Zhang M-N, Ma S-F, Zou L-P. Intermittent oral levetiracetam reduced recurrence of febrile seizure accompanied with epileptiform discharge: a pilot study. Italian Journal of Pediatrics .2018; 44:70.
Hu L-Y, Zou L-P, Zhong J-M, Gao L, Zhao J-B, Xiao N, et al. Febrile seizure recurrence reduced by intermittent oral levetiracetam. Annals of Clinical and Translational Neurology.2014; 1(3): 171–179.
Salehiomran M, Hoseini SM, Ghabeli Juibary A. Intermittent diazepam versus continuous phenobarbital to prevent recurrence of febrile seizures: a randomized controlled trial. Iran J Child Neurol. 2016;10:21–24
Khosroshahi n, faramarzi f, Salamati P, Haghighi Sm, Kamrani K. Diazepam versus clobazam for intermittent prophylaxis of febrile seizures. ındian Pediatr. 2011;78(1):38-40.
Offringa m, newton R. Prophylactic drug management for febrile seizures in children (Review). Evid Based Child Health. 2013;8(4): 1376-485.
Offringa m, newton R, Cozijnsen ma, nevitt Sj. Prophylactic drug management for febrile seizures in children. Cochrane Database Syst Rev. 2017;2:CD003031.
