Epilepsi ve Otizm
Özet
Otizm Spektrum Bozukluğu (OSB) ile epilepsi arasındaki ilişki, genetik yatkınlıklar ve nörolojik mekanizmalarla açıklanabilen oldukça yaygın ve karmaşık bir birlikteliktir. OSB tanılı bireylerde epileptik nöbetler ve subklinik EEG anormallikleri genel popülasyondan belirgin şekilde daha sık görülmekte, bu durum sıklıkla ciddi davranışsal ve bilişsel işlev bozukluklarıyla ilişkilendirilmektedir. Tuberoz skleroz, Dravet ve Rett sendromu gibi genetik temelli sendromlarda ise bu iki durumun eş zamanlı görülme oranı artmakta, tedavi yaklaşımlarında subklinik epileptik deşarjların yönetimi nöroprotektif bir seçenek olarak değerlendirilmektedir.
The relationship between Autism Spectrum Disorder (ASD) and epilepsy is a common and complex association explainable through genetic predispositions and neurological mechanisms. Epileptic seizures and subclinical EEG abnormalities occur significantly more frequently in individuals with ASD than in the general population, which is often linked to severe behavioral and cognitive dysfunctions. In genetically based syndromes such as Tuberous Sclerosis, Dravet, and Rett syndrome, the co-occurrence of these conditions increases, and the management of subclinical epileptic discharges in treatment approaches is considered a potential neuroprotective strategy.
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