Otoimmün Ensefalitler
Özet
Otoimmün ensefalit, nöronal hücre yüzeyindeki veya hücre içindeki proteinlere karşı gelişen immün yanıt sonucu ortaya çıkan, klinik ve etiyolojik olarak heterojen bir beyin inflamasyonudur. Hastalar sıklıkla davranış değişikliği, psikoz, nöbet ve bilişsel bozukluklar gibi geniş bir yelpazede nöropsikiyatrik semptomlarla başvurmaktadır. Erken tanı ve immün süpresif tedavi, prognozun iyileştirilmesi ve kalıcı nörolojik hasarın önlenmesi açısından kritik öneme sahiptir.
Autoimmune encephalitis is a heterogeneous inflammatory brain condition resulting from immune responses against neuronal cell surface or intracellular proteins, rather than direct infectious invasion. Patients typically present with a broad spectrum of neuropsychiatric symptoms, including behavioral changes, psychosis, seizures, and cognitive impairment. Early diagnosis and prompt immunotherapy are critical to improving patient outcomes and preventing long-term neurological damage.
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