Santral Sinir Sisteminin Bakteriyel Enfeksiyonları
Özet
Santral sinir sisteminin bakteriyel enfeksiyonları, yüksek morbidite ve mortalite oranları nedeniyle çocuk sağlığında kritik bir öneme sahiptir. Hızlı tanı ve uygun antimikrobiyal tedavi, komplikasyonları önlemek ve nörolojik sekelleri azaltmak için temel zorunluluktur. Enfeksiyonlar hematojen yolla veya doğrudan yayılım sonucu gelişebilir ve genellikle yoğun bakım desteği gerektiren ciddi klinik tablolarla seyreder. İyileşme süreci, etken organizmaya göre antibiyotik seçimi ve gerekirse cerrahi müdahale ile yönetilir.
Bacterial infections of the central nervous system pose a significant threat to pediatric health due to high risks of morbidity, mortality, and permanent neurological sequelae. Rapid identification and immediate initiation of targeted antibiotic therapy are essential to manage these complex clinical conditions effectively. These infections frequently arise from either systemic hematogenous spread or localized anatomical extensions, necessitating rigorous supportive care. Successful management often integrates antibiotic regimens with surgical interventions depending on the specific complications and the pathogen involved.
Referanslar
Panuganti SM, Nadel S. Acute Bacterial Meningitis Beyond the Neonatal Period. Long SS, Prober CG, Fischer M editors. Principles and practice of pediatric infectious diseases. 5th Edition. Philadelphia; Elsevier; 2018. p.278-287.
Guennec LL, Bourdoulous S. Pathogenesis and Pathophysiology of Bacterial Infections of the CNS. Chrétien F, Wong KT, Sharer LR, Keohane C, Gray F editors. Infections of the central nervous system: pathology and genetics. 1st Edition. Hoboken, NJ; Wiley-Blackwell; 2020. p. 279-295.
Techasaensiri C, Messine AF, Katz K, et al. Epidemiology and evolution of invasive pneumococcal disease caused by multidrug resistant serotypes of 19A in the 8 Years after implementation of pneumococcal conjugate vaccine immunization in Dallas, Texas. Pediatr Infect Dis J 2010;29:294–300.
Kim KS. Bacterial Meningitis Beyond the Neonatal Period. Cherry JD, Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ editors. Feigin and Cherry’s Textbook of Pediatric Infectious Diseases. 8th Edition. Philadelphia; Elsevier; 2019. p.309-335.
Lin TY, Chrane DF, Nelson JD, et al. Seven days of ceftriaxone therapy is as effective as ten days’ treatment for bacterial meningitis. JAMA. 1985;253:3559-3563.
Ampofo K, Bender J, Sheng X, et al. Seasonal invasive pneumococcal disease in children: role of preceding respiratory viral infection. Pediatrics 2008;122:229–237.
Kim KS. Acute bacterial meningitis in infants and children. Lancet Infect Dis 2010;10:32–42.
Brouwer MC, Tunkel AR, van de Beek D. Epidemiology, diagnosis, and antimicrobial treatment of acute bacterial meningitis. Clin Microbiol Rev 2010;23:467–492.
Harper MB. Meningitis. Shah SS, Kemper AR, Ratner AJ editors. Pediatric Infectious Diseases: Essentials for Practice. 2nd Edition. McGraw-Hill Education; 2019. p.159-166.
Singhi P, Singhi S. Acute Bacterial Meningitis. Singhi P, Griffin DE, Newton CR editors. Central Nervous System Infections in Childhood. 1st Edition. London; Mac Keith Press; 2014. p.160-181.
Sormunen P, Kallio MJT, et al. C-reactive protein is useful in distinguishing Gram stain-negative bacterial meningitis from viral meningitis. J Pediatr. 1999;134:725-729.
Dubos F, Martinet A, Gendrel D, et al. Clinical decision rules for evaluating meningitis in children. Curr Opin Neurol. 2009;22:288-293.
Bonsu BK, Harper MB. Utility of the peripheral blood white blood cell count for identifying sick young infants who need lumbar puncture. Ann Emerg Med. 2003;41:206-214.
Sáez-Llorens X, O’Ryan M. Cefepime in the empiric treatment of meningitis in children. Pediatr Infect Dis. 2001;20:356-361.
American Academy of Pediatrics. Pneumococcal infections. In: Pickering LK, ed. 2006 Red Book: Report of the Committee on Infectious Diseases. 27th ed. Elk Grove Village, Ill: American Academy of Pediatrics; 2006:525-537.
Paris MM, Hickey SM, Vocher MI, et al. Effect of dexamethasone on therapy of experimental penicillin- and cephalosporin-resistant pneumococcal meningitis. Antimicrob Agents Chemother 1994;38:1320.
Molyneux E, Nizami SQ, Saha S, et al. 5 Versus 10 days of treatment with ceftriaxone for bacterial meningitis in children: a double-blind randomised equivalence study. Lancet 2011;377:1837–1845.
Mcintyre PB, Berkey CS, King SM, et al. Dexamethasone as adjunctive therapy in bacterial meningitis. JAMA. 1997;278:925-931.
Brady MT, Kaplan SL, Taber LH. Association between persistence of pneumococcal meningitis and dexamethasone administration. J Pediatr. 1981;99:924-926.
Feigin RD, Dodge PR. Bacterial meningitis: newer concepts of pathophysiology and neurologic sequelae. Pediatr Clin North Am. 1976;23:541-556.
Feldman WE, Ginsburg CB, McCracken GH, et al. Relation of concentrations of Haemophilus influenzae type b in cerebrospinal fluid to late sequelae of patients with meningitis. J Pediatr. 1982;100:209-218.
Pomeroy SL, Holmes SJ, Dodge PR, et al. A prospective evaluation of the neurologic sequelae of bacterial meningitis in children with special emphasis on late seizures. N Engl J Med. 1990;323:1651-1657.
Feigin RD, Stechenberg BW, Chang MJ, et al. Prospective evaluation of treatment of Hemophilus influenzae meningitis. J Pediatr. 1976;88:773-775.
Edmond K, Clark A, Korczak VS, et al. Global and regional risk of disabling sequelae from bacterial meningitis: a systematic review and meta-analysis. Lancet Infect Dis. 2010;10:317-328.
Wicher V, Wicher K. Pathogenesis of maternal-fetal syphilis revisited. Clin Infect Dis 2001;33:354–363.
Kollmann TR, Dobson S. Syphilis. Remington JS, et al. Editors. Infectious Diseases of the Fetus and Newborn Infant, 7th Edition. Philadelphia;Elsevier; 2010, p.525–556.
Swanson D, Harrison CJ. Chronic Meningitis. Long SS, Prober CG, Fischer M editors. Principles and practice of pediatric infectious diseases. 5th Edition. Philadelphia; Elsevier; 2018. p.288-295.
Marra CM. Neurosyphilis. Curr Neurol Neurosci Rep 2004;4:435–440.
Noordhoek GT, Wolters EC, de longe ME, et al. Detection by polymerase chain reaction of Treponema pallidum DNA in cerebrospinal fluid from neurosyphilis patients before and after antibiotic treatment. J Clin Microbiol 1991;29:1976-1984.
Espariat AT, Sharer LR. Cerebral Nocardiosis. Chrétien F, Wong KT, Sharer LR, Keohane C, Gray F editors. Infections of the central nervous system: pathology and genetics. 1st Edition. Hoboken, NJ; Wiley-Blackwell; 2020. p. 343-347.
31- Wilson, J.W. (2012). Nocardiosis: update and clinical review. Mayo Clin. Proc. 87: 403–407.
Espariat AT. Cerebral Actinomycosis. Chrétien F, Wong KT, Sharer LR, Keohane C, Gray F editors. Infections of the central nervous system: pathology and genetics. 1st Edition. Hoboken, NJ; Wiley-Blackwell; 2020. p. 337-341.
Roth, J. and Ram, Z. (2010). Intracranial infections caused by Actinomyces species. World Neurosurg. 74:261–262.
Sáez-Llorens X, Guevara JN. Parameningeal Infections. Cherry JD, Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ editors. Feigin and Cherry’s Textbook of Pediatric Infectious Diseases. 8th Edition. Philadelphia; Elsevier; 2019. p.336-344.
Fischer EG, McLennan JE, Suzuki Y. Cerebral abscess in children. Am J Dis Child. 1981;135(8):746-749.
Harrison CJ. Focal Suppurative Infections of the Nervous System. Long SS, Prober CG, Fischer M editors. Principles and practice of pediatric infectious diseases. 5th Edition. Philadelphia; Elsevier; 2018. p.329-338.
Mathisen GE, Johnson JP. Brain abscess. Clin Infect Dis. 1997;25(4):763-779.
Fitzpatrick MO, Gan P. Contrast-enhanced computed tomography in the early diagnosis of cerebral abscess. Br Med J 1999;319:239–240.
Hlavin ML, Kaminski HJ, Fenstermaker RA, et al. Intracranial suppuration: a modern decade of postoperative subdural empyema and epidural abscess. Neurosurgery 1994;34:974–981.
Mat Nayan SA, Mohd Haspani MS, Abd Latiff AZ, et al. Two surgical methods used in 90 patients with intracranial subdural empyema. J Clin Neurosci. 2009;16(12):1567-1571.
Espariat AT, Roux A, Still M, Zanello M, Zah‐Bi G, Hmeydia G, Oppenheim C, Wolff M, Pallud J, Chrétien F. Pyogenic Infections of the CNS 2:(Brain Abscess, Subdural Abscess or Empyema, Epidural Abscess, Septic Embolism, and Suppurative Intracranial Phlebitis). Chrétien F, Wong KT, Sharer LR, Keohane C, Gray F editors. Infections of the central nervous system: pathology and genetics. 1st Edition. Hoboken, NJ; Wiley-Blackwell; 2020. p. 309-318.
Kojan, S. and Al‐Jumah, M. (2006). Infection related cerebral venous thrombosis. J Pak Med Assoc 56:494–497.
Tan TQ, Mithal LB. Infections Related to Prosthetic or Artificial Devices. Cherry JD, Harrison GJ, Kaplan SL, Steinbach WJ, Hotez PJ editors. Feigin and Cherry’s Textbook of Pediatric Infectious Diseases. 8th Edition. Philadelphia; Elsevier; 2019. p.725-743.
Singhi P. Focal intracranial suppuration. Singhi S. Singhi P, Griffin DE, Newton CR editors. Central Nervous System Infections in Childhood. 1st Edition. London; Mac Keith Press; 2014. p.182-201.