Nöroborelyoz
Özet
Lyme nöroborelyoz (LNB), kene kaynaklı Borrelia enfeksiyonunun cilt tutulumundan sonra gelişen ve tüm Lyme olgularının yaklaşık %15'inde görülen multisistemik bir komplikasyondur. Hastalık genellikle eritema migrans ile başlar ve tedavi edilmediğinde kraniyal sinir felçleri, menenjit ve nadiren ensefalit gibi ciddi nörolojik tablolara yol açabilir. Tanıda klinik öykü, fizik muayene ve beyin omurilik sıvısında (BOS) intratekal antikor sentezinin gösterilmesi kritik öneme sahiptir; tedavi süreci ise hastalığın evresine göre uygun antibiyotik rejimleri ile yönetilir. Çocuklarda yetişkinlere kıyasla daha iyi bir prognoza sahip olan LNB, erken teşhis ve doğru antibiyotik yönetimiyle başarılı şekilde tedavi edilebilmektedir.
Lyme neuroborreliosis (LNB) is a multisystemic complication occurring in approximately 15% of all Lyme borreliosis cases, triggered by tick-borne Borrelia infections. The disease typically begins with erythema migrans and, if left untreated, can progress to severe neurological conditions such as cranial nerve palsies, meningitis, and rarely, encephalitis. Diagnosis relies critically on clinical history, physical examination, and the demonstration of intrathecal antibody synthesis in the cerebrospinal fluid (CSF), while the treatment process is managed with appropriate antibiotic regimens based on the stage of the infection. Generally having a better prognosis in children than in adults, LNB can be successfully treated with early diagnosis and proper antibiotic management.
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