Pediatrik Nöroloji Hastalarının Yoğunbakım Sürecinde Ağrı ve Sedasyon Uygulamaları
Özet
Pediatrik yoğun bakım ünitelerinde nörolojik hastalığı olan çocukların takibi, hem altta yatan kronik durumlar hem de yoğun bakım süreçlerine bağlı gelişen ağrı ve anksiyete yönetimi nedeniyle özel bir klinik dikkat gerektirmektedir. Ağrı ve anksiyetenin uygun şekilde sedasyon ve analjezi ile kontrol altına alınması, çocukların stres yanıtlarını baskılayarak iyileşme sürecini desteklerken, aşırı sedasyonun beraberinde getirebileceği komplikasyon risklerini minimize etmek hayati önem taşımaktadır. Tedavi edici yaklaşımlar, hastanın konforunu ve nörolojik durumunun izlenebilirliğini korumayı hedefleyen objektif ve sübjektif monitorizasyon yöntemleri ile titizlikle dengelenmelidir. Bu süreçte kullanılan farmakolojik ajanların farmakokinetik özellikleri ve potansiyel yan etkileri, yoğun bakım hastalarının organ fonksiyonlarındaki değişimler göz önünde bulundurularak dikkatle seçilmelidir.
Management of pediatric neurology patients in intensive care units requires specialized clinical attention due to both underlying chronic conditions and pain or anxiety associated with critical care interventions. Controlling pain and anxiety through appropriate sedation and analgesia supports recovery by suppressing stress responses, while it is critical to balance these benefits against the potential complications of over-sedation. Therapeutic approaches must be carefully aligned with objective and subjective monitoring methods that prioritize patient comfort and the ability to monitor neurological status. The pharmacokinetics and potential side effects of administered agents must be selected with careful consideration of the changes in organ function typical of these intensive care patients.
Referanslar
Myles PS, Leslie K, McNeil J, Forbes A, Chan MT. Bispectral index monitoring to prevent awareness during anaesthesia: the B-Aware randomised controlled trial. Lancet. 2004 29;363(9423):1757-1763.
Gimson A, Smith M. Processed EEG from depth of anaesthesia monitors and seizures: A scoping review. Seizure.2021;91:198-206.
Sessler CN, Gosnell MS, Grap MJ, et al. The Richmond Agitation-Sedation Scale: validity and reliability in adult intensive care unit patients. Am J Respir Crit Care Med. 2002 15;166(10):1338-1344.
Ambuel B, Hamlett KW, Marx CM, Blumer JL. Assessing distress in pediatric intensive care environments: the COMFORT scale. J Pediatr Psychol. 1992;17(1):95-109.
Johansson M, Kokinsky E. The COMFORT behavioural scale and the modified FLACC scale in paediatric intensive care. Nurs Cri tCare. 2009;14(3):122-130.
Lu H, Rosenbaum S. Developmental pharmacokinetics in pediatric populations. J Pediatr Pharmacol Ther. 2014;19(4):262-276.
Jang SM, Infante S, Abdi Pour A. Drug Dosing Considerations in Critically Ill Patients Receiving Continuous Renal Replacement Therapy. Pharmacy (Basel). 2020;7;8(1):18.
Jacobi J, Fraser GL, Coursin DB, et al. Task Force of the American College of Critical Care Medicine (ACCM) of the Society of Critical Car eMedicine (SCCM), American Society of Health-System Pharmacists (ASHP), American College of Chest Physicians. Clinical practice guidelines for the sustained use of sedatives and analgesics in the critically ill adult. Crit Care Med. 2002;30(1):119-141.
Wells N, Pasero C, McCaffery M. Improving the Quality of Care Through Pain Assessment and Management. In: Hughes RG, editor. PatientSafetyandQuality: An Evidence-Based Handbook for Nurses. Rockville (MD): Agencyfor Healthcare Researchand Quality (US); 2008 Apr. Chapter 17. PMID: 21328759.
Gommers D, Bakker J. Medications for analgesia and sedation in the intensive care unit: an overview. CritCare. 2008;12 Suppl 3(Suppl 3):S4.
Krekels EH, Tibboel D, de Wildt SN, et al. Evidence-based morphine dosing for postoperative neonates and infants. Clin Pharmacokinet. 2014;53(6):553-563.
Ko SH, Kim DC, Han YJ, Song HS. Small-dosefentanyl: optimal time of injection for blunting the circulatory responses to tracheal intubation. Anesth Analg. 1998;86(3):658-661.
Playfor SD. Analgesia and sedation in critically ill children. Arch Dis Child Educ Pract Ed. 2008;93(3):87-92.
Fletcher D, Martinez V. Opioid-induced hyperalgesia in patient safter surgery: a systematic review and a meta-analysis. Br J Anaesth. 2014;112(6):991-1004.
Jahr JS, Lee VK. Intravenous acetaminophen. Anesthesio lClin. 2010;28(4):619-645.
Forrest JB, Heitlinger EL, Revell S. Ketorolac for postoperative pain management in children. Drug Saf. 1997;16(5):309-329.
Kaye AD, Urman RD, Rappaport Y, et al. Multimodal analgesia as an essential part of enhanced recovery protocols in the ambulatory settings. J Anaesthesiol Clin Pharmacol. 2019;35(Suppl 1):S40-S45.
Neunhoeffer F, Hanser A, Esslinger M, et al. Ketamine Infusion as a Counter Measure for Opioid Tolerance in Mechanically Ventilated Children: A Pilot Study. Paediatr Drugs. 2017;19(3):259-265.
Basker S, Singh G, Jacob R. Clonidine in paediatrics-a review. Indian J Anaesth. 2009;53(3):270-280.
Reddy SK, Jones JJ, Gordish-Dressman H, Pestieau SR. Dexmedetomidine as an Opioid-Sparing Agent in Pediatric Craniofacial Surgery. Children (Basel). 2020;7(7):68.
Olutoye OA, Glover CD, Diefenderfer JW, et al. The effect of intraoperative dexmedetomidine on postoperative analgesia and sedation in pediatric patients undergoing tonsillectomy and adenoidectomy. Anesth Analg. 2010;111(2):490-495.
Vet NJ, Kleiber N, Ista E, de Hoog M, de Wildt SN. Sedation in Critically Ill Children with Respiratory Failure. Front Pediatr. 2016;24;4:89.
Albrecht S, MD, Ihmsen H, Hering W. Theeffect of age on the pharmacokinetics and pharmacodynamics of midazolam. Clin Pharmacol Ther 1999;65:630–639.
Cheng C, MD, Roemer C, MD, Pereira J. When midazolam fails. J Pain Symptom Manag 2002; 23:256-265.
Barnes S, Yaster M, Kudchadkar SR. Pediatric Sedation Management. Pediatr Rev. 2016;37:203-212.
Boylan GB, Rennie JM, Chorley G, et al. Second-lin eanticonvulsant treatment of neonatal seizures: a video-EEG monitoringstudy. Neurology. 2004;62(3):486-488.
Bauer TM, Ritz R, Haberthür C, et al. Prolonged sedation due to accumulation of conjugated metabolites of midazolam. Lancet. 1995;346(8968):145-147.
Hoffman WE, PhD, Balyas I, PhD, Harkinder M, MD . GABAα6 reseptörs mediate midazolam induced anxiolysis. J Clin Anaesth 2002;14:206–209.
Greenblatt DJ, Harmatz JS, Friedman H, Locniskar A, Shader RI. A large-sample study of diazepam pharmacokinetics. Ther Drug Monit. 1989;11(6):652-657.
Löscher W, Rogawski MA. How theories evolved concerning the mechanism of action of barbiturates. Epilepsia. 2012;53:12-25.
Weerink MAS, Struys MMRF, Hannivoort LN, Barends CRM, Absalom AR, Colin P. Clinical Pharmacokinetics and Pharmacodynamics of Dexmedetomidine. Clin Pharmacokinet. 2017;56:893-913.
Mason KP, O'Mahony E, Zurakowski D, Libenson MH. Effects of dexmedetomidine sedation on the EEG in children. Paediatr Anaesth. 2009;19(12):1175-1183.
Erickson SJ, Millar J, Anderson BJ, Festa MS, Straney L, Shehabi Y, LongDA;Baby SPICE Investigators and the Australianand New Zealand Intensive Care Society Paediatric Study Group (ANZICS-PSG). Dexmedetomidine Sedation in Mechanically Ventilated Critically Ill Children: A Pilot Randomized Controlled Trial. Pediatr Crit Care Med. 2020;21(9):e731-e739.
Sperotto F, Mondardini MC, Dell'Oste C, et al. Pediatric Neurological Protection and Drugs (PeNPAD) Study Group of the Italian Society of Neonatal and Pediatric Anesthesia and Intensive Care (SARNePI). Efficacy and Safety of Dexmedetomidine for Prolonged Sedation in the PICU: A Prospective Multicenter Study (PROSDEX). Pediatr Crit Care Med. 2020;21(7):625-636.
Takeuchi M, Nemoto S, Suzuki Y, Takahashi N, Takenaka N, Takata A, Kobayashi M. Age-Specific Dose Regimens of Dexmedetomidine for Pediatric Patients in Intensive Care Following Elective Surgery: A Phase 3, Multicenter, Open-LabelClinical Trial in Japan. Pediatr Crit Care Med. 2021 Apr 2.
Coluzzi F, Angelini A, Simmaco M, et al. The effect of dexmedetomidine on status epilepticus in a patient with anti-NMDA receptor encephalitis. Can J Anaesth. 2020;67(11):1677-1679.
Bhaskar, Nisha MD; Thakkar, et al. Dexmedetomidine for Electrocorticography in Patients With Lennox–Gastaut Syndrome Presenting for Epilepsy Surgery: A Case Report, A & A Practice: August 15, 2019 - Volume 13 - Issue 4 - p 148-150.
Hemphill S, McMenamin L, Bellamy MC, Hopkins PM. Propofol infusion syndrome: a structured literatüre review and analysis of published case reports. Br J Anaesth. 2019;122(4):448-459.
Krajčová A, Waldauf P, Anděl M, Duška F. Propofol infusion syndrome: a structured review of experimental studies and 153 published case reports. Crit Care. 2015 Nov12;19:398.
Hughes CG, McGrane S, Pandharipande PP. Sedation in the intensive care setting. Clin Pharmacol. 2012;4:53-63.
Park S, Choi AY, Park E, et al. Effects of continuous ketamine infusion on hemodynamics and mortality in critically ill children. PLoSOne. 2019;14(10):e0224035.
Perbet S, Verdonk F, Godet T, et al. Low doses of ketamine reduce delirium but not opiate consumption in mechanically ventilated and sedated ICU patients: A randomised double-blind controltrial. Anaesth Crit Care Pain Med. 2018;37(6):589-595.
Rai S, Drislane FW. Treatment of Refractory and Super-refractory Status Epilepticus. Neurotherapeutics. 2018;15(3):697-712.
Kishk OA, Simone S, Lardieri AB, Graciano AL, Tumulty J, Edwards S. AntipsychoticTreatment of Delirium in Critically Ill Children: A Retrospective Matched Cohort Study. J Pediatr Pharmacol Ther. 2019;24(3):204-213.
Yaghmai BF, DiGennaro JL, Irby GA, Deeter KH, Zimmerman JJ. A Pediatric Sedation Protocol for Mechanically Ventilated Patients Requires Sustenance Beyond Implementation. Pediatr Crit Care Med. 2016;17(8):721-726.
Gupta K, Gupta VK, Jayashree M, Singhi S. Randomized controlled trial of interrupted versus continuous sedative infusions in ventilated children. Pediatr Crit Care Med. 2012;13(2):131-135.
Vet NJ, de Wildt SN, Verlaat CW, Knibbe CA, Mooij MG, vanWoensel JB, vanRosmalen J, Tibboel D, de Hoog M. A randomized controlled trial of Daily sedation interruption in critically ill children. Intensive Care Med. 2016;42(2):233-244.
Cunliffe M, McArthur L, Dooley F. Managing sedation withdrawal in children who undergo prolonged PICU admission after discharge to the ward. Paediatr Anaesth. 2004;14(4):293-298.
Keogh SJ, LongDA,Horn DV. Practice guidelines for sedation and analgesia management of critically ill children: a pilot study evaluating guideline impact and feasibility in the PICU. BMJ Open. 2015;5(3):e006428.
Best KM, Wypij D, Asaro LA, Curley MA; Randomized Evaluation of Sedation Titration For Respiratory Failure Study Investigators. Patient, Process, and System Predictors of Iatrogenic Withdrawal Syndrome in Critically Ill Children. Crit Car eMed. 2017;45(1):e7-e15.
Fisher D, Grap MJ, Younger JB, Ameringer S, Elswick RK. Opioid withdrawal signs and symptoms in children: frequency and determinants. Heart Lung. 2013;42(6):407-413.
Amigoni A, Vettore E, Brugnolaro V, et al. High doses of benzodiazepine predict analgesic and sedative drug withdrawal syndrome in paediatric intensive care patients. Acta Paediatr. 2014;103(12):e538-543.
Ávila-Alzate JA, Gómez-Salgado J, Romero-Martín M, Martínez-Isasi S, Navarro-Abal Y, Fernández-García D. Assessment and treatment of the withdrawal syndrome in paediatric intensive care units: Systematic review. Medicine (Baltimore). 2020;99(5):e18502.