İdrarda Renk Değişiklikleri
Özet
Bu metin, bebeklik ve çocukluk döneminde görülen idrar renk değişikliklerinin tarihsel gelişimini, tanısal önemini ve olası klinik nedenlerini kapsamlı bir şekilde incelemektedir. İdrarın normal berrak ve sarı renginin ürokrom maddesinden kaynaklandığı, dehidrasyon veya çeşitli hastalıkların bu rengi kırmızıdan yeşile, maviden siyaha kadar değiştirebileceği belirtilmektedir. Özellikle ilaçlar, besinler ve metabolik bozuklukların bu renk değişimlerindeki rolü vurgulanırken; detaylı anamnez ve idrar analizinin teşhis koymadaki kritik değerine dikkat çekilmektedir.
This text comprehensively examines the historical development, diagnostic significance, and potential clinical causes of urine color changes observed in infancy and childhood. It states that the normal clear and yellow color of urine is derived from urochrome, and various diseases, dehydration, or substances can alter this color to shades of red, green, blue, or even black. The role of medications, foods, and metabolic disorders in these color variations is emphasized, highlighting that detailed patient history and urinalysis are critical tools for accurate diagnosis and treatment.
Referanslar
Antic T, DeMay RM. The fascinating history of urine examination. Journal of the American Society of Cytopathology. 2014;3:103-107.
Magiorkinis E, Diamantis A. The fascinating story of urine examination: from uroscopy to the era of microscopy and beyond. Diagnostic Cytopathology. 2015;43:1020-1036.
Drummond KN, Michael AF, Ulstrom RA, et al. The blue diaper syndrome: familial hypercalcemia with nephrocalcinosis and indicanuria; a new familial disease, with definition of the metabolic abnormality. The American Journal of Medicine. 1964;37: 928-948.
Su FH, Chung SY, Chen MH, et al. Case analysis of purple urine-bag syndrome at a long-term care service in a community hospital. Chang Gung Medical Journal. 2005;28: 636-642.
Adonis-Koffy L, Gonzales E, Nathanson S, et al. Alkaptonuria: a rare cause of urine discoloration. Report of a case in a newborn. Archives de Pediatrie. 2000;7: 844-846.
Thadani H, Deacon A, Peters T. Diagnosis and management of porphyria. BMJ. 2000;320: 1647-1651.
Aycock RD, Kass DA. Abnormal urine color. South Medical Journal. 2012;105(1): 43-47.
Higgins T, Eckfeld J, Barton JC, Doumas BT. Hemoglobin, Iron, and Bilirubin. In: Burtis CA, Ashwood ER, Bruns DE (eds) Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. 5th ed. Elsevier; 2012.p. 985-1030.
Vera M, Molano A, Rodriguez P. Turbid white urine. NDT Plus 2010;3(1): 45-47.
Riley RS, McPherson RA. Basic Examination of Urine. In: McPherson RA, Pincus MR (eds.) Henry’s clinical diagnosis and management by laboratory methods. 23rd ed. St. Louis, Missouri: Elsevier; 2017. p. 442-480.
Eisner BH, Tanrikut C, Dahl DM. Chyluria secondary to lymphorenal fistula. Kidney International. 2009;76(1): 126.
Pan CG, Avner ED. Clinical evaluation of the child with hematuria In: Kliegman RM (ed) Nelson textbook of pediatrics. 20th ed. Philadelphia, PA, Elsevier; 2016. p.2494-2496.
Yoo S, Cho MH, Baek HS, et al. Characteristics of pediatric rhabdomyolysis and the associated risk factors for acute kidney injury: a retrospective multicenter study in Korea. Kidney Research Clinical Practice. 2021;40(4): 673-686.
Jeng JY, Franz WB. Orange stains in a healthy neonate’s diaper. Clinical Pediatrics. 2014;53(9): 908-910.
Distelmaier F, Herebian D, Atasever C, et al. Blue diaper syndrome and PCSK1 mutations. Pediatrics. 2018;141(5): 501-505.
Leclercq P, Loly C, Delanaye P, et al. Green urine. Lancet. 2009; 373:1462.
Morell-Garcia D, Bauça JM, Garcia-Suquia A, et al. Green urine: A bezoar effect. Journal of Clinical Anesthesia. 2016;33: 306-308.
Milne MD. Hartnup disease. Biochemical Journal. 1969;111(3):3-4.
Teke Kisa P, Gunduz M, Dorum S, et al. Alkaptonuria in Turkey: Clinical and molecular characteristics of 66 patients, European Journal of Medical Genetics. 2021;64(5): 104197.
