Febril Konvülziyon
Özet
Bu metin, çocukluk çağının en sık görülen nörolojik durumlarından biri olan febril konvülziyonu (ateşli nöbet) kapsamlı bir şekilde ele almaktadır. Çalışmada, nöbetlerin tanımı, basit ve kompleks olarak sınıflandırılması, genetik ve çevresel risk faktörleri ile tanı ve tedavi yöntemleri güncel literatür ışığında detaylandırılmaktadır. Özellikle aile eğitimi ve nöbet anında yapılması gereken ilk yardım müdahaleleri vurgulanarak, hekimler ve ebeveynler için pratik bir rehber sunulmaktadır.
This text, provides a comprehensive analysis of febrile convulsions, one of the most common acute neurological conditions in childhood. The study details the definition of seizures, their classification as simple or complex, genetic and environmental risk factors, and diagnostic and treatment methods in light of current literature. By emphasizing family education and first aid interventions during a seizure, it offers a practical guide for both physicians and parents.
Referanslar
Consensus statement. Febrile seizures: long-term management of children with fever-associated seizures. Pediatrics. 1980 Dec;66(6):1009-12.
Guidelines for epidemiologic studies on epilepsy. Commission on Epidemiology and Prognosis, International League Against Epilepsy. Epilepsia. 1993;34(4):592-6.
Subcommittee on Febrile Seizures; American Academy of Pediatrics. Neurodiagnostic evaluation of the child with a simple febrile seizure. Pediatrics. 2011;127(2):389-94.
Berg AT, Berkovic SF, Brodie MJ, et al. Revised terminology and concepts for organization of seizures and epilepsies: report of the ILAE Commission on Classification and Terminology, 2005-2009. Epilepsia. 2010;51(4):676-85.
Seinfeld S, Shinnar S. Febrile seizures. In: Swaiman KF, Ashwal S, Ferriero DM, et al (eds). Swaiman’s Pediatric Neurology: Principles and Practice (6th ed) Philadelphia: Elsevier, 2017: 519-23.
Patterson JL, Carapetian SA, Hageman JR, et al. Febrile seizures. Pediatr Ann. 2013;42(12):249-54.
Leung AK, Hon KL, Leung TN. Febrile seizures: an overview. Drugs Context. 2018;16;7:212536.
Graves RC, Oehler K, Tingle LE. Febrile seizures: risks, evaluation, and prognosis. Am Fam Physician. 2012;85(2):149-53.
Patel N, Ram D, Swiderska N, et al. Febrile seizures. BMJ. 2015;351:h4240.
Shinnar S, Hesdorffer DC, Nordli DR Jr, et al. Phenomenology of prolonged febrile seizures: results of the FEBSTAT study. Neurology. 2008;71(3):170-76.
Mewasingh LD. Febrile seizures. BMJ Clin Evid. 2014;2014:0324.
Laino D, Mencaroni E, Esposito S. Management of Pediatric Febrile Seizures. Int J Environ Res Public Health. 2018;15(10):2232.
Smith DK, Sadler KP, Benedum M. Febrile Seizures: Risks, Evaluation, and Prognosis. Am Fam Physician. 2019;99(7):445-450.
Canpolat M, Per H, Gumus H, Elmali F, et al. Investigating the prevalence of febrile convulsion in Kayseri, Turkey: An assessment of the risk factors for recurrence of febrile convulsion and for development of epilepsy. Seizure. 2018;55:36-47.
Canpolat M, Kumandas S, Poyrazoglu HG,et al. Prevalence and risk factors of epilepsy among school children in Kayseri City Center, an urban area in Central Anatolia, Turkey. Seizure. 2014;23(9):708-16.
Canpolat M, Kumandas S. (2020). Febril Konvülziyon. Sefer Kumandaş, Mehmet Canpolat (Ed), Çocukluk Çağı Epilepsileri içinde (s. 72-90). Ankara: Türkiye Klinikleri
Knudsen FU. Febrile seizures – treatment and outcome. Brain Dev 1996;18:438–49.
Ozmen M, et al. (2010) Pediatrik Noroloji, Febril konvulziyon. Hasanoğlu E, Dusunsel R, Bideci A (Ed), Temel Pediatri içinde (s. 1264-1267). Ankara: Güneş Kitabevi,
Yousefichaijan P, Eghbali A, Rafeie M, et al. The relationship between iron deficiency anemia and simple febrile convulsion in children. J Pediatr Neurosci. 2014;9(2):110–14
Millichap JG, Millichap JJ. Role of viral infections in the etiology of febrile seizures. Pediatr Neurol. 2006;35(3):165–72
Epstein LG, Shinnar S, Hesdorffer DC, et al; FEBSTAT study team. Human herpesvirus 6 and 7 in febrile status epilepticus: the FEBSTAT study. Epilepsia. 2012;53(9):1481-8.
Babl FE, Lewena S, Brown L. Vaccination-related adverse events. Pediatr Emerg Care. 2006;22(7):514–19.
Duffy J, Weintraub E, Hambidge SJ, et al; Vaccine Safety Datalink. Febrile seizure risk after vaccination in children 6 to 23 months. Pediatrics. 2016;138(1):pii: e20160320
Duffy J, Hambidge SJ, Jackson LA, et al; Vaccine Safety Datalink. Febrile seizure risk after vaccination in children one to five months of age. Pediatr Neurol. 2017;76:72–78.
Yakut A. Febril konvülziyon.(2010) Gökçay E, Sönmez FM, Topaloğlu h, Tekgül H, Gürer YKY (Ed). (Türkiye Çocuk Nöroloji Derneği Yönetim ve Yayın Kurulu). Çocuk Nörolojisi içinde (s.319-26) Ankara: Anıl Gurup Matbaacılık.
Leung AK, Robson WL. Febrile seizures. J Pediatr Health Care. 2007;21(4):250–55.
Tu YF, Wang LW, Wang ST, et al. Postnatal steroids and febrile seizure susceptibility in preterm children. Pediatrics. 2016;137(4):pii:e20153404.
Vestergaard M, Wisborg K, Henriksen TB, et al. Prenatal exposure to cigarettes, alcohol, and coffee and the risk for febrile seizures. Pediatrics. 2005;116(5):1089–94.
Gholipoor P, Saboory E, Ghazavi A, et al. Prenatal stress potentiates febrile seizure and leads to long-lasting increase in cortisol blood levels in children under 2 years old. Epilepsy Behav. 2017;72:22–27.
Aziz KT, Ahmed N, Nagi AG. Iron deficiency anaemia as risk factor for simple febrile seizures: a case control study. J Ayub Med Coll Abbottabad. 2017;29(2):316–19.
Nasehi MM, Sakhaei R, Moosazadeh M, et al. Comparison of serum zinc levels among children with simple febrile seizure and control group: a systematic review. Iran J Child Neurol. 2015;9(1):17–24.
Namakin K, Zardast M, Sharifzadeh G, et al. Serum trace elements in febrile seizure: a case-control study. Iran J Child Neurol. 2016;10(3):57–60.
Özkale Y, Erol İ, Kılıçarslan B, et al. Serum vitamin B12, folic acid, and homocysteine levels in children with febrile seizure. Turk J Pediatr. 2015;57(4):345–52.
Chung, S. Febrile seizures. Korean J. Pediatr. 2014, 57, 384–95.
Oluwabusi, T.; Sood, S.K. Update on the management of simple febrile seizures: Emphasis on minimal intervention. Curr. Opin. Pediatr. 2012, 24, 259–65.
National Institute for Health and Care Excellence. Clinical Knowledge Summaries: Febrile Seizures; NICE: London, UK, 2013.
Naric, J.; Rissland, J.; Simon, A. Role of multiplex PCR analysis in children with febrile seizures. Wien. Med. Wochenschr. 2016, 167, 246–50.
Green SM, Rothrock SG, Clem KJ, et al. Can seizures be the sole manifestation of meningitis in febrile children? Pediatrics. 1993 Oct;92(4):527-34.
Millichap JJ. Clinical features and evaluation of febrile seizures. In: Post TW, ed. UpToDate. Waltham, MA.
Sadleir LG, Scheffer IE. Febrile seizures. BMJ. 2007;334(7588):307–11.
Steering Committee on Quality Improvement and Management, Subcommittee on Febrile Seizures American Academy of Pediatrics. Febrile seizures: clinical practice guideline for the long-term management of the child with simple febrile seizures. Pediatrics. 2008;121(6):1281–86.
Natsume J, Hamano SI, Iyoda K, et al. New guidelines for management of febrile seizures in Japan. Brain Dev. 2017;39(1):2–9.
Capovilla G, Mastrangelo M, Romeo A, et al. Recommendations for the management of “febrile seizures”: Ad Hoc Task Force of LICE Guidelines Commission. Epilepsia. 2009;50(Suppl 1):2–6.
Cuestas E. Is routine EEG helpful in the management of complex febrile seizures? Arch Dis Child. 2004;89(3):290.
Nordli DR Jr, Moshé SL, Shinnar S, et al; FEBSTAT Study Team. Acute EEG findings in children with febrile status epilepticus: results of the FEBSTAT study. Neurology. 2012 Nov 27;79(22):2180-6.
Seinfeld S, Glauser TA, Shinnar S. Febrile Seizures. Pellock JM, Nordii DR, Sankar R, Wheless JW, eds. Pellock’s Pediatric Epilepsy, 4th edn, New York: Demos Medical Publishing. 2017: pp.505-16.
Shinnar S. Febrile seizures. In: Treatment of Pediatric Neurologic Disorders. 2005. p. 73.
Seinfeld S, Shinnar S, Sun S, et al. FEBSTAT Study Team. Emergency management of febrile status epilepticus: results of the FEBSTAT study. Epilepsia. 2014;55(3):388-95.
Wong V, Rosman NP, Fukuyama Y, et al. Clinical guideline on management of febrile convulsion. HK J Paediatr 2002; 7: 143- 51.
Yüksel A. Febril konvülziyonlara güncel yaklaşım. Sempozyum Dizisi 2006; 53: 57- 66
Hampers LC, Spina LA. Evaluation and management pediatric febrile seizures in the emergency department. Emerg Med Clin 2011; 1: 83-93
Canpolat M, Kumandaş S. Çocuklarda Status Epileptikus Yönetimi. Turkiye Klinikleri J Pediatr. Sci 2018;14(1):58-81
Erkek N, Öztürk N, Şevketoğlu E. Çocuk acil Tıp ve Yoğun Bakım Derneği. Status Epileptikus Tedavi Protokolü2017.http://www.cayd.org.tr/gorseller/files/protokolle C%CC%a7aYD%20Status%20Epileptikus%20protokolu%CC%88%20(0102218).pdf.
Heinen F, ed. Medication. NeuroKids Child Nerology Workbook Diagnosis and Therapy Mind Maps. 1st ed. Stuttgart: W. Kohlhammer gmbH. 2017.p.389-555.
Luo S, Ran M, Luo Q, et al. Alternating Acetaminophen and Ibuprofen versus Monotherapies in Improvements of Distress and Reducing Refractory Fever in Febrile Children: a Randomized Controlled Trial. Paediatr Drugs. 2017;19(5):479-86.
Fetveit A. Assessment of febrile seizures in children. Eur J Pediatr. 2008 Jan;167(1):17-27. doi: 10.1007/s00431-007-0577-x. Epub 2007 Sep 2.
Canpolat M, Kaya Özçora G, Kumandaş S. Konvülsiyonlu Çocuğa Yaklaşım. Turkiye Klinikleri J Fam Med-Special Topics. 2017; 8(5):353-68.
Kimia AA, Bachur RG, Torres A, et al. Febrile seizures: emergency medicine perspective. Curr Opin Pediatr. 2015 Jun;27(3):292-7.
Sugai K. Current management of febrile seizures in Japan: an overview. Brain Dev. 2010 Jan;32(1):64-70. doi: 10.1016/j.braindev.2009.09.019. Epub 2009 Oct 22.
Baumann RJ, Duffner PK. Treatment of children with simple febrile seizures: the AAP practice parameter. American Academy of Pediatrics. Pediatr Neurol. 2000;23(1):11–7.
Offringa M, Newton R, Cozijnsen MA, et al. Prophylactic Drug Management for Febrile Seizures in Children. The Cochrane Library. 2017.
Herranz JL, Armijo JA, Arteaga R. Effectiveness and Toxicity of Phenobarbital, Primidone, and Sodium Valproate in the Prevention of Febrile Convulsions, Controlled by Plasma Levels. Epilepsia. 1984;25(1):89-95.
Siemes H. Anfälle und Epilespsien bei Kindern und Jugendlichen. Stutgart, Thieme Verlag, 2001: 165-80.
Autret E, Billard C, Bertrand P, et al. Double-blind,randomized trial of diazepam versus placebo for prevention of recurrence of febrile seizures. J Pediatr 1990; 177: 490-4.
Neubauer B. Fieberkrämpfe. Giessen Universität Eröfnungsvorlesung Hefte. 2001; 1-20.
Febril Konvülziyon El Rehberi. Ege Üniversitesi Tıp fakültesi PediatriAanabilim Dalı Çocuk Nörolojisi Bilim Dalı. http://cnd.org.tr/ folders/file/fkd_azemson.pdf., 2018.
Fukuyama Y, Seki T, Ohtsuka C, et al. Practical guidelines for physicians in the management of febrile seizures. Brain Dev. 1996 Nov-Dec;18(6):479-84.
