Kilo Kaybı

Özet

İstemsiz kilo kaybı, 6-12 ay içinde vücut ağırlığının %5'inden fazlasının çaba sarf etmeden azalması olarak tanımlanan ve özellikle 65 yaş üstü bireylerde artan morbidite ve mortalite ile ilişkilendirilmiş ciddi bir klinik durumdurEn yaygın etiyolojik nedenler arasında malignite, gastrointestinal hastalıklar ve psikiyatrik bozukluklar yer alırken; tanı süreci kapsamlı bir öykü, fizik muayene ve hedeflenmiş laboratuvar tetkiklerini içeren multidisipliner bir yaklaşımı gerektirmektedir. Tedavi protokolleri doğrudan altta yatan nedene odaklanmakta olup, farmakolojik müdahalelerin yanı sıra diyet düzenlemeleri ve egzersiz gibi destekleyici yöntemlerle hastanın yaşam kalitesinin artırılması hedeflenmektedir.

 

Unintentional weight loss is defined as a spontaneous reduction of more than 5% of body weight within 6-12 months and is a serious clinical condition associated with increased morbidity and mortality, especially in individuals over 65The most common etiological causes include malignancy, gastrointestinal diseases, and psychiatric disorders; the diagnostic process requires a multidisciplinary approach involving a comprehensive history, physical examination, and targeted laboratory tests. Treatment protocols focus directly on the underlying cause, aiming to improve the patient's quality of life through supportive methods such as dietary adjustments and exercise alongside pharmacological interventions.

Referanslar

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Marton KI, Sox HC, Krupp JR. Involuntary weight loss: Diagnostic and prognostic significance. Annals of Internal Medicine. 1981;95(5): 568–574. doi:10.7326/0003-4819-95-5-568

Bosch X, Monclús E, Escoda O, et al. Unintentional weight loss: Clinical characteristics and outcomes in a prospective cohort of 2677 patients. PLoS ONE. 2017;12(4). doi:10.1371/journal.pone.0175125

Jin Y, Cho J, Lee I, et al. Involuntary weight loss and late-life depression in Korean older adults. Iranian Journal of Public Health. 2020;49(4): 637–644. doi:10.18502/ijph.v49i4.3169

Rao S, Kikano EG, Smith DA, et al. Unintentional weight loss: what radiologists need to know and what clinicians want to know. Abdominal Radiology. 2021;46(5): 2236–2250. doi:10.1007/s00261-020-02908-6

Torné Cachot J, Baucells Azcona JM, Blanch Falp J, et al. Isolated involuntary weight loss: Epidemiology and predictive factors of malignancy. Medicina Clínica (English Edition). 2019;152(10): 384–390. doi:10.1016/j.medcle.2019.03.008

Wong CJ. Involuntary weight loss. Medical Clinics of North America. 2014. p. 625–643. doi:10.1016/j.mcna.2014.01.012

Sökmen ÜN, Dişcigil G. Sarcopenia in the elderly. The Journal of Turkish Family Physician. 2017;8(2): 49–54. doi:10.15511/tjtfp.17.00249

Aligué J, Vicente M, Arnau A, et al. Etiologies and 12-month mortality in patients with isolated involuntary weight loss at a rapid diagnostic unit. PLoS ONE. 2021;16(9 September). doi:10.1371/journal.pone.0257752

Gaddey HL, Holder K. Unintentional Weight Loss in Older Adults. American Family Physician. 2014;89(9):718-722

Nicholson BD, Hamilton W, O’Sullivan J, et al. Weight loss as a predictor of cancer in primary care: A systematic review and meta-analysis. British Journal of General Practice. 2018;68(670): e311–e322. doi:10.3399/bjgp18X695801

Gelecek

15 Ekim 2022

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