Çocuk ve Ergenlerde Duygudurum Bozuklukları ve Uyku
Özet
Çocuk ve ergenlerde duygudurum bozuklukları ile uyku arasındaki ilişkiyi inceleyen bu çalışma, uykunun fiziksel ve ruhsal sağlık üzerindeki hayati önemini vurgulayarak, uyku bozukluklarının klinik tabloyu karmaşıklaştırdığını ortaya koymaktadır. Araştırmalar, majör depresif bozukluğu olan gençlerin büyük bir kısmında insomnia veya hipersomnia görüldüğünü, bu sorunların depresyonun şiddetini artırdığını ve tedavi yanıtını olumsuz etkilediğini göstermektedir. Özellikle ergenlerde uyku problemleri ile intihar düşüncesi ve kendine zarar verme davranışı arasında güçlü bir bağ tespit edilmiştir. Pediatrik bipolar bozuklukta ise azalan uyku ihtiyacı manik dönemlerin ayırt edici bir belirtisi olarak öne çıkarken, uyku düzensizliklerinin duygudurum ataklarını tetikleyebildiği saptanmıştır. Tedavi tarafında, farmakolojik yöntemlerin yanı sıra uykusuzluk için uygulanan bilişsel davranışçı terapinin (BDT-I), hem uyku kalitesini hem de duygudurum semptomlarını iyileştirmede etkili olduğu belirtilmektedir. Sonuç olarak, uyku bozukluklarının erken teşhisi ve tedavisi, çocuk ve ergenlerde duygudurum bozukluklarının önlenmesi ve başarılı bir şekilde yönetilmesi için kritik bir müdahale hedefi olarak değerlendirilmektedir.
This study examining the relationship between mood disorders and sleep in children and adolescents emphasizes the vital importance of sleep for physical and mental health, revealing that sleep disorders complicate the clinical picture. Research shows that a large proportion of youth with major depressive disorder experience insomnia or hypersomnia, and these problems increase the severity of depression and negatively affect treatment response. A strong link has been identified between sleep problems and suicidal ideation and self-harming behavior, especially in adolescents. In pediatric bipolar disorder, decreased need for sleep stands out as a distinguishing symptom of manic episodes, while it has been found that sleep irregularities can trigger mood episodes. On the treatment side, in addition to pharmacological methods, cognitive behavioral therapy for insomnia (CBT-I) is stated to be effective in improving both sleep quality and mood symptoms. Consequently, early diagnosis and treatment of sleep disorders are considered a critical intervention target for the prevention and successful management of mood disorders in children and adolescents.
Referanslar
Lofthouse N, Fristad M, Splaingard M, et al. Parent and child reports of sleep problems associated with early-onset bipolar spectrum disorders. J Fam Psychol. 2007;21(1):114.
Verkhratsky A, Nedergaard M, Steardo L, et al. Sleep and Mood Disorders. Front psychiatry. 2020;10:981.
Euston DR, Steenland HW. Memories—getting wired during sleep. Science. 2014;344(6188):1087–1088.
Benca RM, Peterson MJ. Insomnia and depression. Sleep Med. 2008;9:3–9.
Asarnow LD, McGlinchey E, Harvey AG. The effects of bedtime and sleep duration on academic and emotional outcomes in a nationally representative sample of adolescents. J Adolesc Heal. 2014;54(3):350–356.
Johnson EO, Roth T, Breslau N. The association of insomnia with anxiety disorders and depression: exploration of the direction of risk. J Psychiatr Res. 2006;40(8):700–708.
Sivertsen B, Harvey AG, Reichborn-Kjennerud T, et al. Later emotional and behavioral problems associated with sleep problems in toddlers: a longitudinal study. JAMA Pediatr. 2015;169(6):575–582.
McGlinchey EL, Harvey AG. Risk behaviors and negative health outcomes for adolescents with late bedtimes. J Youth Adolesc. 2015;44(2):478–488.
Harvey AG, Hein K, Dolsen MR, et al. Modifying the impact of eveningness chronotype (“night-owls”) in youth: A randomized controlled trial. J Am Acad Child Adolesc Psychiatry. 2018;57(10):742–754.
American Psychiatric Association. DSM-5 Diagnostic Classification. In: Diagnostic and Statistical Manual of Mental Disorders. 2013.
Asarnow LD, Mirchandaney R. Sleep and mood disorders among youth. Child Adolesc Psychiatr Clin. 2021;30(1):251–268.
Fava M. Daytime sleepiness and insomnia as correlates of depression. J Clin Psychiatry. 2004;65(16):27–32.
Puig-Antich J, Goetz R, Hanlon C, et al. Sleep architecture and REM sleep measures in prepubertal children with major depression: a controlled study. Arch Gen Psychiatry. 1982;39(8):932–939.
Liu X, Buysse DJ, Gentzler AL, et al. Insomnia and hypersomnia associated with depressive phenomenology and comorbidity in childhood depression. Sleep. 2007;30(1):83–90.
Ryan ND, Puig-Antich J, Ambrosini P, et al. The clinical picture of major depression in children and adolescents. Arch Gen Psychiatry. 1987;44(10):854–861.
Yilmaz E, Sedky K, Bennett DS. The relationship between depressive symptoms and obstructive sleep apnea in pediatric populations: a meta-analysis. J Clin Sleep Med. 2013;9(11):1213–1220.
Roberts RE, Lewinsohn PM, Seeley JR. Symptoms of DSM-III-R major depression in adolescence: evidence from an epidemiological survey. J Am Acad Child Adolesc Psychiatry. 1995;34(12):1608–1617.
Whalen DJ, Silk JS, Semel M, et al. Caffeine consumption, sleep, and affect in the natural environments of depressed youth and healthy controls. J Pediatr Psychol. 2008;33(4):358–367.
Ford DE, Kamerow DB. Epidemiologic study of sleep disturbances and psychiatric disorders: an opportunity for prevention? Jama. 1989;262(11):1479–1484.
Breslau N, Roth T, Rosenthal L, et al. Sleep disturbance and psychiatric disorders: a longitudinal epidemiological study of young adults. Biol Psychiatry. 1996;39(6):411–418.
Asarnow JR, Bai S, Babeva KN, et al. Sleep in youth with repeated self‐harm and high suicidality: Does sleep predict self‐harm risk? Suicide Life‐Threatening Behav. 2020;50(6):1189–1197.
Selvi Y, Aydin A, Boysan M, et al. Associations between chronotype, sleep quality, suicidality, and depressive symptoms in patients with major depression and healthy controls. Chronobiol Int. 2010;27(9–10):1813–1828.
Chan JWY, Lam SP, Li SX, et al. Eveningness and insomnia: independent risk factors of nonremission in major depressive disorder. Sleep. 2014;37(5):911–917.
Ivanenko A, Crabtree VM, Gozal D. Sleep and depression in children and adolescents. Sleep Med Rev. 2005;9(2):115–129.
Puig-Antich J, Goetz R, Hanlon C, et al. Sleep architecture and REM sleep measures in prepubertal major depressives: Studies during recovery from the depressive episode in a drug-free state. Arch Gen Psychiatry. 1983;40(2):187–192.
Forbes EE, Bertocci MA, Gregory AM, et al. Objective sleep in pediatric anxiety disorders and major depressive disorder. J Am Acad Child Adolesc Psychiatry. 2008;47(2):148–155.
Dahl RE, Ryan ND, Birmaher B, et al. Electroencephalographic sleep measures in prepubertal depression. Psychiatry Res. 1991;38(2):201–214.
Arana-Lechuga Y, Nuñez-Ortiz R, Terán-Pérez G, et al. Sleep-EEG patterns of school children suffering from symptoms of depression compared to healthy controls. World J Biol Psychiatry. 2008;9(2):115–120.
Armitage R, Emslie GJ, Hoffmann RF, et al. Ultradian rhythms and temporal coherence in sleep EEG in depressed children and adolescents. Biol Psychiatry. 2000;47(4):338–350.
Lahmeyer HW, Poznanski EO, Bellur SN. EEG sleep in depressed adolescents. Am J Psychiatry. 1983;140(9):1150–1153.
Knowles JB, MacLean AW. Age-related changes in sleep in depressed and healthy subjects. A meta-analysis. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol. 1990;3(4):251–259.
Goetz RR, Puig-Antich J, Dahl RE, et al. EEG sleep of young adults with major depression: a controlled study. J Affect Disord. 1991;22(1–2):91–100.
Dahl RE, Ryan ND, Matty MK, et al. Sleep onset abnormalities in depressed adolescents. Biol Psychiatry. 1996;39(6):400–410.
Rao U, Dahl RE, Ryan ND, et al. Heterogeneity in EEG sleep findings in adolescent depression: unipolar versus bipolar clinical course. J Affect Disord. 2002;70(3):273–280.
Armitage R, Hoffmann R. Sleep electrophysiology of major depressive disorders. Curr Rev Mood Anxiety Disord. 1997;1:139–151.
Goetz RR, Puig-Antich J, Ryan N, et al. Electroencephalographic sleep of adolescents with major depression and normal controls. Arch Gen Psychiatry. 1987;44(1):61–68.
Dahl RE, Puig-Antich J, Ryan ND, et al. EEG sleep in adolescents with major depression: the role of suicidality and inpatient status. J Affect Disord. 1990;19(1):63–75.
Naylor MW, Shain BN, Shipley JE. REM latency in psychotically depressed adolescents. 1990;28:161-164.
Robert JJT, Hoffmann RF, Emslie GJ, et al. Sex and age differences in sleep macroarchitecture in childhood and adolescent depression. Sleep. 2006;29(3):351–358.
Bertocci MA, Dahl RE, Williamson DE, et al. Subjective sleep complaints in pediatric depression: a controlled study and comparison with EEG measures of sleep and waking. J Am Acad Child Adolesc Psychiatry. 2005;44(11):1158–1166.
Lofthouse N, Gilchrist R, Splaingard M. Mood-related sleep problems in children and adolescents. Child Adolesc Psychiatr Clin. 2009;18(4):893–916.
Dahl RE. The regulation of sleep and arousal: Development and psychopathology. Dev Psychopathol. 1996;8(1):3–27.
Rao U, Dahl RE, Ryan ND, et al. The relationship between longitudinal clinical course and sleep and cortisol changes in adolescent depression. Biol Psychiatry. 1996;40(6):474–484.
Goetz RR, Wolk SI, Coplan JD, et al. Premorbid polysomnographic signs in depressed adolescents: a reanalysis of EEG sleep after longitudinal follow-up in adulthood. Biol Psychiatry. 2001;49(11):930–942.
J. Emslie G, Armitage R, Weinberg WA, et al. Sleep polysomnography as a predictor of recurrence in children and adolescents with major depressive disorder. Int J Neuropsychopharmacol. 2001;4(2):159–168.
Armitage R, Emslie GJ, Hoffmann RF, et al. Delta sleep EEG in depressed adolescent females and healthy controls. J Affect Disord. 2001;63(1–3):139–148.
Armitage R, Hoffmann RF, Emslie GJ, et al. Sleep microarchitecture as a predictor of recurrence in children and adolescents with depression. Int J Neuropsychopharmacol. 2002;5(3):217–218.
Morehouse RL, Kusumakar V, Kutcher SP, et al. Temporal coherence in ultradian sleep EEG rhythms in a never-depressed, high-risk cohort of female adolescents. Biol Psychiatry. 2002;51(6):446–456.
Adler I, Weidner K, Eberhard-Gran M, et al. The impact of maternal symptoms of perinatal insomnia on social-emotional child development: a population-based, 2-year follow-up study. Behav Sleep Med. 2021;19(3):303–317.
Morales-Muñoz I, Lemola S, Saarenpää-Heikkilä O, et al. Parent-reported early sleep problems and internalising, externalising and dysregulation symptoms in toddlers. BMJ Paediatr open. 2020;4(1): e000622.
Jansen PW, Saridjan NS, Hofman A, et al. Does disturbed sleeping precede symptoms of anxiety or depression in toddlers? The generation R study. Psychosom Med. 2011;73(3):242–249.
Troxel WM, Trentacosta CJ, Forbes EE, et al. Negative emotionality moderates associations among attachment, toddler sleep, and later problem behaviors. J Fam Psychol. 2013;27(1):127.
Whalen DJ, Gilbert KE, Barch DM, et al. Variation in common preschool sleep problems as an early predictor for depression and anxiety symptom severity across time. J Child Psychol Psychiatry. 2017;58(2):151–159.
Hatzinger M, Brand S, Perren S, et al. In pre-school children, sleep objectively assessed via sleep-EEGs remains stable over 12 months and is related to psychological functioning, but not to cortisol secretion. J Psychiatr Res. 2013;47(11):1809–1814.
Gregory AM, Rijsdijk FV, Lau JYF, et al. The direction of longitudinal associations between sleep problems and depression symptoms: a study of twins aged 8 and 10 years. Sleep. 2009;32(2):189–199.
Alvaro PK, Roberts RM, Harris JK. A systematic review assessing bidirectionality between sleep disturbances, anxiety, and depression. Sleep. 2013;36(7):1059–1068.
Greene G, Gregory AM, Fone D, et al. Childhood sleeping difficulties and depression in adulthood: the 1970 British Cohort Study. J Sleep Res. 2015;24(1):19–23.
Gregory AM, O’connor TG. Sleep problems in childhood: a longitudinal study of developmental change and association with behavioral problems. J Am Acad Child Adolesc Psychiatry. 2002;41(8):964–971.
Johnson EO, Chilcoat HD, Breslau N. Trouble sleeping and anxiety/depression in childhood. Psychiatry Res. 2000;94(2):93–102.
Gregory AM, Eley TC. Sleep problems, anxiety and cognitive style in school‐aged children. Infant Child Dev An Int J Res Pract. 2005;14(5):435–444.
Armstrong JM, Ruttle PL, Klein MH, et al. Associations of child insomnia, sleep movement, and their persistence with mental health symptoms in childhood and adolescence. Sleep. 2014;37(5):901–909.
Steinsbekk S, Wichstrøm L. Stability of sleep disorders from preschool to first grade and their bidirectional relationship with psychiatric symptoms. J Dev Behav Pediatr. 2015;36(4):243–51.
Shanahan L, Copeland WE, Angold A, et al. Sleep problems predict and are predicted by generalized anxiety/depression and oppositional defiant disorder. J Am Acad Child Adolesc Psychiatry. 2014;53(5):550–558.
O’Connor TG, Caprariello P, Blackmore ER, et al. Prenatal mood disturbance predicts sleep problems in infancy and toddlerhood. Early Hum Dev. 2007;83(7):451–458.
Toffol E, Lahti-Pulkkinen M, Lahti J, et al. Maternal depressive symptoms during and after pregnancy are associated with poorer sleep quantity and quality and sleep disorders in 3.5-year-old offspring. Sleep Med. 2019;56:201–210.
Taylor AK, Netsi E, O’Mahen H, et al. The association between maternal postnatal depressive symptoms and offspring sleep problems in adolescence. Psychol Med. 2017;47(3):451–459.
Emslie GJ, Kennard BD, Mayes TL, et al. Insomnia moderates outcome of serotonin-selective reuptake inhibitor treatment in depressed youth. J Child Adolesc Psychopharmacol. 2012;22(1):21–28.
Nyer M, Farabaugh A, Fehling K, et al. Relationship between sleep disturbance and depression, anxiety, and functioning in college students. Depress Anxiety. 2013;30(9):873–880.
Lovato N, Gradisar M. A meta-analysis and model of the relationship between sleep and depression in adolescents: recommendations for future research and clinical practice. Sleep Med Rev. 2014;18(6):521–529.
Alfano CA, Zakem AH, Costa NM, et al. Sleep problems and their relation to cognitive factors, anxiety, and depressive symptoms in children and adolescents. Depress Anxiety. 2009;26(6):503–512.
Manglick M, Rajaratnam SM, Taffe J, et al. Persistent sleep disturbance is associated with treatment response in adolescents with depression. Aust New Zeal J Psychiatry. 2013;47(6):556–563.
Gregory AM, Sadeh A. Sleep, emotional and behavioral difficulties in children and adolescents. Sleep Med Rev. 2012;16(2):129–136.
McGlinchey EL, Reyes‐Portillo JA, Turner JB, et al. Innovations in Practice: The relationship between sleep disturbances, depression, and interpersonal functioning in treatment for adolescent depression. Child Adolesc Ment Health. 2017;22(2):96–99.
Edinger JD, Manber R, Buysse DJ, et al. Are patients with childhood onset of insomnia and depression more difficult to treat than are those with adult onsets of these disorders? A report from the TRIAD study. J Clin Sleep Med. 2017;13(2):205–213.
Urrila AS, Karlsson L, Kiviruusu O, et al. Sleep complaints in adolescent depression: one year naturalistic follow-up study. BMC Psychiatry. 2014;14(1):1–9.
Kovacs M, Feinberg TL, Crouse-Novak MA, et al. Depressive disorders in childhood: I. A longitudinal prospective study of characteristics and recovery. Arch Gen Psychiatry. 1984;41(3):229–237.
Strober M, Lampert C, Schmidt S, et al. The course of major depressive disorder in adolescents: I. Recovery and risk of manic switching in a follow-up of psychotic and nonpsychotic subtypes. J Am Acad Child Adolesc Psychiatry. 1993;32(1):34–42.
Emslie GJ, Rush AJ, Weinberg WA, et al. Recurrence of major depressive disorder in hospitalized children and adolescents. J Am Acad Child Adolesc Psychiatry. 1997;36(6):785–792.
Kennard B, Silva S, Vitiello B, et al. Remission and residual symptoms after short-term treatment in the Treatment of Adolescents with Depression Study (TADS). J Am Acad Child Adolesc Psychiatry. 2006;45(12):1404–1411.
Nierenberg AA, Husain MM, Trivedi MH, et al. Residual symptoms after remission of major depressive disorder with citalopram and risk of relapse: a STAR* D report. Psychol Med. 2010;40(1):41–50.
Tao R, Emslie GJ, Mayes TL, et al. Symptom improvement and residual symptoms during acute antidepressant treatment in pediatric major depressive disorder. J Child Adolesc Psychopharmacol. 2010;20(5):423–430.
Perlis RH, Miyahara S, Marangell LB, et al. Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD). Biol Psychiatry. 2004;55(9):875–881.
Dombrovski AY, Cyranowski JM, Mulsant BH, et al. Which symptoms predict recurrence of depression in women treated with maintenance interpersonal psychotherapy? Depress Anxiety. 2008;25(12):1060–1066.
Franzen PL, Buysse DJ. Sleep disturbances and depression: risk relationships for subsequent depression and therapeutic implications. Dialogues Clin Neurosci. 2008;10(4):473.
Park JH, Yoo J, Kim SH. Associations between non‐restorative sleep, short sleep duration and suicidality: Findings from a representative sample of K orean adolescents. Psychiatry Clin Neurosci. 2013;67(1):28–34.
Roberts RE, Roberts CR, Chen IG. Functioning of adolescents with symptoms of disturbed sleep. J Youth Adolesc. 2001;30(1):1–18.
Singareddy R, Krishnamurthy VB, Vgontzas AN, et al. Subjective and objective sleep and self-harm behaviors in young children: a general population study. Psychiatry Res. 2013;209(3):549–553.
Wong MM, Brower KJ, Zucker RA. Sleep problems, suicidal ideation, and self-harm behaviors in adolescence. J Psychiatr Res. 2011;45(4):505–11.
Liu X, Buysse DJ. Sleep and youth suicidal behavior: a neglected field. Curr Opin Psychiatry. 2006;19(3):288–93.
Liu X. Sleep and adolescent suicidal behavior. Sleep. 2004;27(7):1351–8.
Kang S-G, Lee YJ, Kim SJ, et al. Weekend catch-up sleep is independently associated with suicide attempts and self-injury in Korean adolescents. Compr Psychiatry. 2014;55(2):319–25.
Goldstein TR, Bridge JA, Brent DA. Sleep disturbance preceding completed suicide in adolescents. J Consult Clin Psychol. 2008;76(1):84.
Kupfer DJ, Coble P, Kane J, et al. Imipramine and EEG sleep in children with depressive symptoms. Psychopharmacology (Berl). 1979;60(2):117–1123.
Shain BN, Naylor MW, Shipley JE, et al. Imipramine effects on sleep in depressed adolescents: a preliminary report. 1990;28:459-462.
Armitage R, Emslie G, Rintelmann J. The effect of fluoxetine on sleep EEG in childhood depression: a preliminary report. Neuropsychopharmacology. 1997;17(4):241–245.
Kallepallı BR, Bhatara VS, Fogas BS, et al. Trazodone is only slightly faster than fluoxetine in relieving insomnia in adolescents with depressive disorders. J Child Adolesc Psychopharmacol. 1997;7(2):97–107.
Brent D, Emslie G, Clarke G, et al. Switching to another SSRI or to venlafaxine with or without cognitive behavioral therapy for adolescents with SSRI-resistant depression: the TORDIA randomized controlled trial. Jama. 2008;299(8):901–913.
Åslund L, Arnberg F, Kanstrup M, et al. Cognitive and behavioral interventions to improve sleep in school-age children and adolescents: a systematic review and meta-analysis. J Clin Sleep Med. 2018;14(11):1937–1947.
Blake MJ, Sheeber LB, Youssef GJ, et al. Systematic review and meta-analysis of adolescent cognitive–behavioral sleep interventions. Clin Child Fam Psychol Rev. 2017;20(3):227–249.
Meltzer LJ, Mindell JA. Systematic review and meta-analysis of behavioral interventions for pediatric insomnia. J Pediatr Psychol. 2014;39(8):932–948.
Clarke G, McGlinchey EL, Hein K, et al. Cognitive-behavioral treatment of insomnia and depression in adolescents: A pilot randomized trial. Behav Res Ther. 2015;69:111–118.
Manber R, Buysse DJ, Edinger J, et al. Efficacy of cognitive-behavioral therapy for insomnia combined with antidepressant pharmacotherapy in patients with comorbid depression and insomnia: a randomized controlled trial. J Clin Psychiatry. 2016;77(10):0.
Carney CE, Edinger JD, Kuchibhatla M, et al. Cognitive behavioral insomnia therapy for those with insomnia and depression: a randomized controlled clinical trial. Sleep. 2017;40(4):zsx019.
McCall W V, Benca RM, Rosenquist PB, et al. Reducing suicidal ideation through insomnia treatment (REST-IT): a randomized clinical trial. Am J Psychiatry. 2019;176(11):957–965.
Carskadon MA, Vieira C, Acebo C. Association between puberty and delayed phase preference. Sleep. 1993;16(3):258–262.
Asarnow LD, Bei B, Krystal A, et al. Circadian preference as a moderator of depression outcome following cognitive behavioral therapy for insomnia plus antidepressant medications: a report from the TRIAD study. J Clin Sleep Med. 2019;15(4):573–580.
Nottelmann E. National Institute of Mental Health research roundtable on prepubertal bipolar disorder. J Am Acad Child Adolesc Psychiatry. 2001;40(8):871–878.
Van Meter A, Moreira ALR, Youngstrom E. Updated meta-analysis of epidemiologic studies of pediatric bipolar disorder. J Clin Psychiatry. 2019;80(3):0.
Geller B, Zimerman B, Williams M, et al. Phenomenology of prepubertal and early adolescent bipolar disorder: examples of elated mood, grandiose behaviors, decreased need for sleep, racing thoughts and hypersexuality. J Child Adolesc Psychopharmacol. 2002;12(1):3–9.
Geller B, Zimerman B, Williams M, et al. DSM-IV Mania Symptoms in a Prepubertal and Early Attention-Deficit Hyperactive and Normal Controls. J Child Adolesc Psychopharmacol. 2002;12(1):11–25.
Kowatch RA, Youngstrom EA, Danielyan A, et al. Review and meta-analysis of the phenomenology and clinical characteristics of mania in children and adolescents. Bipolar Disord. 2005;7(6):483–496.
Meyers OI, Youngstrom EA. A Parent General Behavior Inventory subscale to measure sleep disturbance in pediatric bipolar disorder. J Clin Psychiatry. 2008;69(5):840–843.
Harvey AG, Talbot LS, Gershon A. Sleep disturbance in bipolar disorder across the lifespan. Clin Psychol Sci Pract. 2009;16(2):256.
Faedda GL, Baldessarini RJ, Glovinsky IP, et al. Pediatric bipolar disorder: phenomenology and course of illness. Bipolar Disord. 2004;6(4):305–313.
Parker G, Malhi G, Hadzi-Pavlovic D, Parker K. Sleeping in? The impact of age and depressive sub-type on hypersomnia. J Affect Disord. 2006;90(1):73–76.
Roybal DJ, Chang KD, Chen MC, et al. Characterization and factors associated with sleep quality in adolescents with bipolar I disorder. Child Psychiatry Hum Dev. 2011;42(6):724–40.
Baroni A, Hernandez M, Grant M, et al. Sleep disturbances in pediatric bipolar disorder: a comparison between bipolar I and bipolar NOS. Front psychiatry. 2012;3:22.
Lofthouse N, Fristad M, Splaingard M, et al. Web survey of sleep problems associated with early-onset bipolar spectrum disorders. J Pediatr Psychol. 2008;33(4):349–357.
Mehl RC, O’Brien LM, Jones JH, et al. Correlates of sleep and pediatric bipolar disorder. Sleep. 2006;29(2):193–197.
Levenson JC, Soehner A, Rooks B, et al. Longitudinal sleep phenotypes among offspring of bipolar parents and community controls. J Affect Disord. 2017;215:30–36.
Soehner AM, Bertocci MA, Levenson JC, et al. Longitudinal associations between sleep patterns and psychiatric symptom severity in high-risk and community comparison youth. J Am Acad Child Adolesc Psychiatry. 2019;58(6):608–617.
Ritter PS, Höfler M, Wittchen HU, et al. Disturbed sleep as risk factor for the subsequent onset of bipolar disorder–data from a 10-year prospective-longitudinal study among adolescents and young adults. J Psychiatr Res. 2015;68:76–82.
Pancheri C, Verdolini N, Pacchiarotti I, et al. A systematic review on sleep alterations anticipating the onset of bipolar disorder. Eur Psychiatry. 2019;58:45–53.
Wehr TA, Goodwin FK, Wirz-Justice A, et al. 48-hour sleep-wake cycles in manic-depressive illness: naturalistic observations and sleep deprivation experiments. Arch Gen Psychiatry. 1982;39(5):559–565.
Colombo C, Benedetti F, Barbini B, et al. Rate of switch from depression into mania after therapeutic sleep deprivation in bipolar depression. Psychiatry Res. 1999;86(3):267–270.
Gruber J, Miklowitz DJ, Harvey AG, et al. Sleep matters: sleep functioning and course of illness in bipolar disorder. J Affect Disord. 2011;134(1–3):416–420.
Gruber J, Harvey AG, Wang PW, et al. Sleep functioning in relation to mood, function, and quality of life at entry to the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD). J Affect Disord. 2009;114(1–3):41–49.
Lunsford-Avery JR, Judd CM, Axelson DA, et al. Sleep impairment, mood symptoms, and psychosocial functioning in adolescent bipolar disorder. Psychiatry Res. 2012;200(2–3):265–271.
Gershon A, Singh MK. Sleep in adolescents with bipolar I disorder: stability and relation to symptom change. J Clin Child Adolesc Psychol. 2017;46(2):247–257.
Soehner AM, Goldstein TR, Gratzmiller SM, et al. Cognitive control under stressful conditions in transitional age youth with bipolar disorder: Diagnostic and sleep‐related differences in fronto‐limbic activation patterns. Bipolar Disord. 2018;20(3):238–247.
Sylvia L, Salcedo S, Peters A, et al. Do sleep disturbances predict or moderate the response to psychotherapy in bipolar disorder? J Nerv Ment Dis. 2017;205(3):196.
Kowatch RA, Fristad MA, Findling RL, et al. (2009) Clinical manual for management of bipolar disorder in children and adolescents. American Psychiatric Pub.
Biederman J, Mick E, Hammerness P, et al. Open-label, 8-week trial of olanzapine and risperidone for the treatment of bipolar disorder in preschool-age children. Biol Psychiatry. 2005;58(7):589–594.
Tohen M, Kryzhanovskaya L, Carlson G, et al. Olanzapine versus placebo in the treatment of adolescents with bipolar mania. Am J Psychiatry. 2007;164(10):1547–1556.
Pavuluri MN, Graczyk PA, Henry DB, et al. Child-and family-focused cognitive-behavioral therapy for pediatric bipolar disorder: development and preliminary results. J Am Acad Child Adolesc Psychiatry. 2004;43(5):528–537.
Fristad MA. Psychoeducational treatment for school-aged children with bipolar disorder. Dev Psychopathol. 2006;18(4):1289–306.
Miklowitz DJ, Biuckians A, Richards JA. Early-onset bipolar disorder: A family treatment perspective. Dev Psychopathol. 2006;18(4):1247–1265.
Lofthouse N, Fristad MA, Splaingard M, et al. Web-survey of pharmacological and non-pharmacological sleep interventions for children with early-onset bipolar spectrum disorders. J Affect Disord. 2010;120(1–3):267–271.
Harvey AG, Soehner AM, Kaplan KA, et al. Treating insomnia improves mood state, sleep, and functioning in bipolar disorder: a pilot randomized controlled trial. J Consult Clin Psychol. 2015;83(3):564.
Kaplan KA, Harvey AG. Behavioral treatment of insomnia in bipolar disorder. Am J Psychiatry. 2013;170(7):716–720.
