Çocuk ve Ergenlerde Jet Lag

Yazarlar

Elif Abanoz
https://orcid.org/0000-0002-9214-4735

Özet

Jet lag, birden fazla zaman dilimini kapsayan uzun mesafeli uçuşlar sonrası vücudun iç saati ile gidilen yerin gece-gündüz döngüsü arasındaki uyumsuzluktan kaynaklanan geçici bir sirkadiyen ritim bozukluğudur. Bu durum uyku bölünmesi, gündüz uykululuğu, yorgunluk ve sindirim sorunları gibi semptomlarla karakterizedir. Temel mekanizma, melatonin salgılanması ve vücut sıcaklığı değişimlerini yöneten hipotalamustaki biyolojik saatin yeni çevreye yavaş uyum sağlamasıdır. Özellikle çocuklar ve ergenler, hafta içi okul düzeni ve hafta sonu değişen uyku saatleri nedeniyle "sosyal jet lag" riski altındadır; bu da akademik başarı ve psikolojik sağlığı olumsuz etkileyebilir. Doğuya yapılan uçuşlarda sirkadiyen fazın ilerletilmesi, batıya yapılanlarda ise geciktirilmesi gerekir. Tedavi stratejileri arasında stratejik zamanlanmış parlak ışığa maruz kalma, melatoninden kaçınma veya melatonin takviyesi kullanımı yer alır. Seyahat öncesi uyku düzenini kademeli olarak ayarlamak, uçuş sırasında sıvı alımını artırmak ve varış noktasında yerel saate uygun beslenmek semptomları hafifletmeye yardımcı olur. Literatürde yetişkinlere yönelik çalışmalar yaygın olsa da çocuk ve ergenlerde jet lagın etkileri ve tedavisi üzerine daha fazla araştırmaya ihtiyaç duyulmaktadır.

Jet lag is a temporary circadian rhythm disorder caused by the mismatch between the body's internal clock and the day-night cycle of the destination following long-haul flights across multiple time zones. This condition is characterized by symptoms such as sleep fragmentation, daytime sleepiness, fatigue, and gastrointestinal disturbances. The primary mechanism involves the biological clock in the hypothalamus, which regulates melatonin secretion and body temperature changes, adapting slowly to the new environment. Children and adolescents are particularly at risk for "social jet lag" due to shifting sleep schedules between school days and weekends, which can negatively impact academic performance and psychological health. Eastward travel requires advancing the circadian phase, while westward travel requires delaying it. Treatment strategies include strategically timed exposure to bright light, avoiding light, or using melatonin supplements. Gradually adjusting sleep patterns before travel, increasing fluid intake during flights, and eating according to local time upon arrival help alleviate symptoms. While studies on adults are common in the literature, more research is needed on the effects and treatment of jet lag in children and adolescents.

Referanslar

Herxheimer A. Jet lag. BMJ clinical evidence. 2014;2014.

Petrie K, Conaglen JV, Thompson L, Chamberlain K. Effect of melatonin on jet lag after long haul flights. British Medical Journal. 1989;298(6675):705-7.

Randler C, Vollmer C, Kalb N, Itzek-Greulich H. Breakpoints of time in bed, midpoint of sleep, and social jetlag from infancy to early adulthood. Sleep medicine. 2019;57:80-6.

Sack RL, Auckley D, Auger RR, Carskadon MA, Wright Jr KP, Vitiello MV, et al. Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. Sleep. 2007;30(11):1460-83.

Sack RL. The pathophysiology of jet lag. Travel medicine and infectious disease. 2009;7(2):102-10.

Simmons E, McGrane O, Wedmore I. Jet Lag Modification. Current Sports Medicine Reports. 2015;14(2):123-8.

Borbély AA. A two process model of sleep regulation. Hum neurobiol. 1982;1(3):195-204.

Reid KJ, Burgess HJ. Circadian rhythm sleep disorders. Primary Care: Clinics in Office Practice. 2005;32(2):449-73.

St Hilaire MA, Gooley JJ, Khalsa SBS, Kronauer RE, Czeisler CA, Lockley SW. Human phase response curve to a 1 h pulse of bright white light. The Journal of physiology. 2012;590(13):3035-45.

Lewy AJ, Ahmed S, Jackson JML, Sack RL. Melatonin shifts human orcadian rhythms according to a phase-response curve. Chronobiology international. 1992;9(5):380-92.

Lewy AJ, Emens JS, Bernert RA, Lefler BJ. Eventual entrainment of the human circadian pacemaker by melatonin is independent of the circadian phase of treatment initiation: clinical implications. Journal of Biological Rhythms. 2004;19(1):68-75.

Ambesh P, Shetty V, Ambesh S, Gupta SS, Kamholz S, Wolf L. Jet lag: Heuristics and therapeutics. Journal of family medicine and primary care. 2018;7(3):507.

Darien I. International classification of sleep disorders. American Academy of Sleep Medicine. 2014.

Association AP. Diagnostic and statistical manual of mental disorders (DSM-5®): American Psychiatric Pub; 2013.

Coutinho JF, Gonçalves OF, Maia L, Fernandes Vasconcelos C, Perrone-McGovern K, Simon-Dack S, et al. Differential activation of the default mode network in jet lagged individuals. Chronobiology international. 2015;32(1):143-9.

Reid KJ, Abbott SM. Jet lag and shift work disorder. Sleep medicine clinics. 2015;10(4):523-35.

Arendt J. Approaches to the pharmacological management of jet lag. Drugs. 2018;78(14):1419-31.

Arendt J, Marks V. Physiological changes underlying jet lag. British medical journal (Clinical research ed). 1982;284(6310):144.

Zhu L, Zee PC. Circadian rhythm sleep disorders. Neurologic clinics. 2012;30(4):1167-91.

Burgess HJ, Crowley SJ, Gazda CJ, Fogg LF, Eastman CI. Preflight adjustment to eastward travel: 3 days of advancing sleep with and without morning bright light. Journal of biological rhythms. 2003;18(4):318-28.

Suhner A, Schlagenhauf P, Höfer I, Johnson R, Tschopp A, Steffen R. Effectiveness and tolerability of melatonin and zolpidem for the alleviation of jet lag. Aviation, space, and environmental medicine. 2001;72(7):638-46.

Zee PC, Wang-Weigand S, Wright Jr KP, Peng X, Roth T. Effects of ramelteon on insomnia symptoms induced by rapid, eastward travel. Sleep medicine. 2010;11(6):525-33.

Takahashi T, Sasaki M, Itoh H, Yamadera W, Ozone M, Obuchi K, et al. Re‐entrainment of the circadian rhythms of plasma melatonin in an 11‐h eastward bound flight. Psychiatry and clinical neurosciences. 2001;55(3):275-6.

Eastman CI. High-intensity light for circadian adaptation to a 12-h shift of the sleep schedule. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 1992;263(2):R428-R36.

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1 Kasım 2022

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