Geriatrik Hastalarda Rejyonel Anestezi Yönetimi

Yazarlar

Kıvanç Öncü
https://orcid.org/0000-0001-6052-5640

Özet

Geriatrik popülasyondaki artışla birlikte, bu yaş grubunda cerrahi müdahale gerektiren hastalıkların görülme sıklığı da yükselmektedir. Yaşlı hastalarda kronik hastalıklar ve polifarmasi kullanımı, genel anestezi risklerini artırdığından rejyonel anestezi teknikleri modern tıpta stratejik bir öneme sahiptir. Rejyonel anestezi, merkezi etkili ilaçlara ve opioidlere duyarlı olan yaşlılarda sistemik yan etkileri azaltırken, cerrahi sonrası iyileşme (ERAS) protokollerini destekler. Yaşlanma ile birlikte gelişen anatomik değişiklikler, kardiyovasküler kapasitenin azalması ve ilaç metabolizmasındaki yavaşlama, anestezik yönetimini karmaşıklaştırır. Spinal ve epidural bloklar gibi nöroaksiyel tekniklerde, BOS hacmindeki azalma ve doku değişimleri nedeniyle ilaçların daha yüksek seviyelere yayılma riski ve hipotansiyon olasılığı mevcuttur. Ultrason rehberliğinde yapılan periferik sinir blokları ise daha stabil hemodinami ve düşük komplikasyon oranı ile öne çıkmaktadır. Sedasyon ve analjezi için kullanılan ilaç dozlarının geriatrik hastalarda %30-50 oranında azaltılması ve titizlikle ayarlanması kritiktir. Sonuç olarak, multidisipliner bir yaklaşım ve hastaya özgü teknik seçimi, geriatrik cerrahide başarıyı ve güvenliği belirleyen temel unsurlardır.

As the geriatric population grows, the prevalence of diseases requiring surgery in this age group also increases. Due to chronic conditions and polypharmacy, which heighten general anesthesia risks, regional anesthesia techniques hold strategic importance in modern medicine. Regional anesthesia reduces systemic side effects in elderly patients sensitive to centrally acting drugs and opioids, while supporting Enhanced Recovery After Surgery (ERAS) protocols. Anatomic changes, decreased cardiovascular capacity, and slower drug metabolism associated with aging complicate anesthetic management. In neuraxial techniques such as spinal and epidural blocks, there is a risk of medication spreading to higher levels and a possibility of hypotension due to reduced CSF volume and tissue changes. Conversely, ultrasound-guided peripheral nerve blocks stand out for their stable hemodynamics and lower complication rates. It is critical to reduce drug dosages for sedation and analgesia by 30-50% and carefully titrate them for geriatric patients. Consequently, a multidisciplinary approach and patient-specific technique selection are the fundamental elements determining success and safety in geriatric surgery.

Referanslar

Steverson M. Ageing and health [Internet]. World Health Organisation. 2019. [cited 17 October 2020]. https://www.who.int/news-room/fact-sheets/detail/ageing-and-health. [Accessed 3 November 2020

Corcoran E, Kinirons B. Regional anaesthesia in the elderly patient a current perspective. Curr Opin Anaesthesiol. 2021 Feb 1;34(1):48-53. doi: 10.1097/ACO.0000000000000940. PMID: 33315640.

Lin, C., Darling, C. & Tsui, B.C.H. Practical Regional Anesthesia Guide for Elderly Patients. Drugs Aging 36, 213–234 (2019). https://doi.org/10.1007/s40266-018-00631-y

Nordquist D, Halaszynski TM. Perioperative multimodal anesthesia using regional techniques in the aging surgical patient. Pain Res Treat. 2014;2014:1–13.

Lin H-S, Watts JN, Peel NM, et al. Frailty and post-operative outcomes in older surgical patients: a systematic review. BMC Geriatr. 2016;16:157.

Haan J, van Kleef JW, Bloem BR, et al. Cognitive function after spinal or general anesthesia for transurethral prostatectomy in elderly men. J Am Geriatr Soc. 1991;39:596–600.

Ouanes J-PP, Tomas VG, Sieber F. Special anesthetic consideration for the patient with a fragility fracture. Clin Geriatr Med. 2014;30:243–59

Hou R, Wang H, Chen L, et al. POCD in patients receiving total knee replacement under deep vs light anesthesia: a randomized controlled trial. Brain Behav. 2018;8:e00910.

Brown CH, Azman AS, Gottschalk A, et al. Sedation depth during spinal anesthesia and survival in elderly patients undergoing hip fracture repair. Anesth Analg. 2014;118:977–80.

Tsui BC, Wagner A, Finucane B. Regional anaesthesia in the elderly: a clinical guide. Drugs Aging. 2004;21(14):895-910. doi: 10.2165/00002512-200421140-00001. PMID: 15554749.

Eilers H, Niemann CU. Clinically important drug interactions with intravenous anaesthetics in older patients. Drugs Aging. 2003;20:969–80

Yang N, Zuo M-Z, Yue Y, et al. Comparison of C50 for propofol-remifentanil target-controlled infusion and bispectral index at loss of consciousness and response to painful stimulus in elderly and young patients. Chin Med J (Engl). 2015;128:1994–9.

Brandfonbrener M, Landowne M, Shock W. Changes in cardiac output with age. Circulation. 1955;12:557–66.

Sadean MR, Glass PSA. Pharmacokinetics in the elderly. Best Pract Res Clin Anaesthesiol. 2003;17:191–205

Denson D, Coyle D, Thompson G, et al. Alpha1-acid glycoprotein and albumin in human serum bupivacaine binding. Clin Pharmacol Ther. 1984;35:409–15.

Shand DG. alpha 1-Acid glycoprotein and plasma lidocaine binding. Clin Pharmacokinet. 1984;9(Suppl 1):27–31.

Abernethy DR, Kerzner L. Age efects on alpha-1-acid glycoprotein concentration and imipramine plasma protein binding. J Am Geriatr Soc. 1984;32:705–8.

Pacifci GM, Viani A, Taddeucci-Brunelli, et al. Efects of development, aging, and renal and hepatic insufciency as well as hemodialysis on the plasma concentrations of albumin and alpha 1-acid glycoprotein: implications for binding of drugs. Ther Drug Monit. 1986;8:259–63.

Kilinc LT, Sivrikaya GU, Eksioglu B, et al. Comparison of unilateral spinal and continous spinal anesthesia for hip surgery in elderly patients. Saudi J Anaesth. 2013;7:404–9.

Lessing NL, Edwards CC, Lin C, et al. Complex lumbar spine fusion for an elderly patient under spinal anesthesia. Orthopedics. 2017;40:e915–7.

Beaupre LA, Jones CA, Saunders LD, et al. Best practices for elderly hip fracture patients. J Gen Intern Med. 2005;20:1019–25.

Rabinowitz A, Bourdet B, Minville V, et al. The paramedian technique: a superior initial approach to continuous spinal anesthesia in the elderly. Anesth Analg. 2007;105:1855–7

Veering BT. The role of aging in local anesthesia. Pain Rev. 1999;6:167–73.

Carpenter RL, Caplan RA, Brown DL, et al. Incidence and risk factors for side efects of spinal anesthesia. Anesthesiology. 1992;76:906–16.

Ferré F, Marty P, Bruneteau L, et al. Prophylactic phenylephrine infusion for the prevention of hypotension after spinal anesthesia in the elderly: a randomized controlled clinical trial. J Clin Anesth. 2016;35:99–106.

Messina A, Frassanito L, Colombo D, et al. Hemodynamic changes associated with spinal and general anesthesia for hip fracture surgery in severe ASA III elderly population: a pilot trial. Minerva Anestesiol. 2013;79:1021–9.

Hampl K, Steinfeldt T, Wulf H. Spinal anesthesia revisited. Curr Opin Anaesthesiol. 2014;27:549–55.

Geng J, Chen XL, Wang XD, et al. Ultrasound imaging increases frst-attempt success rate of neuraxial block in elderly patients [in Chinese]. Zhonghua Yi Xue Za Zhi. 2016;96:3459–63.

Pumberger M, Memtsoudis SG, Stundner O, et al. An analysis of the safety of epidural and spinal neuraxial anesthesia in more than 100,000 consecutive major lower extremity joint replacements. Reg Anesth Pain Med. 2013;38:515–9.

Faccenda KA, Finucane BT. Complications of regional anaesthesia Incidence and prevention. Drug Saf. 2001;24:413–42.

Simon MJG, Veering BT, Stienstra R, et al. The efects of age on neural blockade and hemodynamic changes after epidural anesthesia with ropivacaine. Anesth Analg. 2002;94:1325–30.

Hirabayashi Y, Shimizu R, Matsuda I, et al. Efect of extradural compliance and resistance on spread of extradural analgesia. Br J Anaesth. 1990;65:508–13.

Shantha TR, Evans JA. The relationship of epidural anesthesia to neural membranes and arachnoid villi. Anesthesiology. 1972;37:543–57.

Van Waesberghe J, Stevanovic A, Rossaint R, et al. General vs. neuraxial anaesthesia in hip fracture patients: a systematic review and meta-analysis. BMC Anesthesiol. 2017;17:87.

Groeben H. Epidural anesthesia and pulmonary function. J Anesth. 2006;20:290–9.

Raj PP. Conduction blocks. In: Raj PP, editor. Textbook of regional anesthesia. London: Churchill Livingstone; 2002. p. 285–306.

El-Morsy GZ, El-Deeb A. The outcome of thoracic epidural anesthesia in elderly patients undergoing coronary artery bypass graft surgery. Saudi J Anaesth. 2012;6:16–21

Guinard JP, Mulroy MF, Carpenter RL. Aging reduces the reliability of epidural epinephrine test doses. Reg Anesth. 1995;20:193–8.

Lenart MJ, Wong K, Gupta RK, et al. The impact of peripheral nerve techniques on hospital stay following major orthopedic surgery. Pain Med. 2012;13:828–34.

Wahal C, Kumar A, Pyati S. Advances in regional anaesthesia: a review of current practice, newer techniques and outcomes. Indian J Anaesth. 2018;62:94.

Li J, Halaszynski T. Neuraxial and peripheral nerve blocks in patients taking anticoagulant or thromboprophylactic drugs: challenges and solutions. Local Reg Anesth. 2015;8:21–32

Brox WT, Chan PH, Cafri G, et al. Similar mortality with general or regional anesthesia in elderly hip fracture patients. Acta Orthop. 2016;87:152–7.

Pintaric TS, Potocnik I, Hadzic A, et al. Comparison of continuous thoracic epidural with paravertebral block on perioperative analgesia and hemodynamic stability in patients having open lung surgery. Reg Anesth Pain Med. 2011;36:256–60.

Aksoy M, Dostbil A, Ince I, et al. Continuous spinal anaesthesia versus ultrasound-guided combined psoas compartment-sciatic nerve block for hip replacement surgery in elderly high-risk patients: a prospective randomised study. BMC Anesthesiol. 2014;14:99.

Mei B, Zha H, Lu X, et al. Peripheral nerve block as a supplement to light or deep general anesthesia in elderly patients receiving total hip arthroplasty: a prospective randomized study. Clin J Pain. 2017;33:1053–9.

Bromage PR. Anatomy. In: Bromage PR, editor. Epidural analgesia. Philadelphia: WB Saunders; 1978. p. 10–67.

Riddell M, Ospina M, Holroyd-Leduc JM. Use of femoral nerve blocks to manage hip fracture pain among older adults in the emergency department: a systematic review. CJEM. 2016;18:245–52

Fraser TW, Doty JF. Peripheral nerve blocks in foot and ankle surgery. Orthop Clin North Am. 2017;48:507–15

Kulhari S, Bharti N, Bala I, et al. Efcacy of pectoral nerve block versus thoracic paravertebral block for postoperative analgesia after radical mastectomy: a randomized controlled trial. Br J Anaesth. 2016;117:382–6.

Baeriswyl M, Kirkham KR, Kern C, et al. The analgesic eficacy of ultrasound-guided transversus abdominis plane block in adult patients. Anesth Analg. 2015;121:1640–54.

Syal K, Chandel A. Comparison of the post-operative analgesic efect of paravertebral block, pectoral nerve block and local infltration in patients undergoing modifed radical mastectomy: a randomised double-blind trial. Indian J Anaesth. 2017;61:643.

Murouchi T, Iwasaki S, Yamakage M. Quadratus lumborum block. Reg Anesth Pain Med. 2016;41:146–50.

El-Boghdadly K, Elsharkawy H, Short A, et al. Quadratus lumborum block nomenclature and anatomical considerations. Reg Anesth Pain Med. 2016;41:548–9.

De Cassai A, Ieppariello G, Ori C. Erector spinae plane block and dual antiplatelet therapy. Minerva Anestesiol. 2018;84:1230–1.

Wong J, Navaratnam M, Boltz G, et al. Bilateral continuous erector spinae plane blocks for sternotomy in a pediatric cardiac patient. J Clin Anesth. 2018;47:82–3.

Leblanc I, Chterev V, Rekik M, et al. Safety and efciency of ultrasound-guided intermediate cervical plexus block for carotid surgery. Anaesth Crit Care Pain Med. 2016;35(2):109–14.

Pandit JJ, Satya-Krishna R, Gration P. Superfcial or deep cervical plexus block for carotid endarterectomy: a systematic review of complications. Br J Anaesth. 2007;99(2):159–69

Bailard NS, Ortiz J, Flores RA. Additives to local anesthetics for peripheral nerve blocks: evidence, limitations, and recommendations. Am J Heal Pharm. 2014;71:373–85.

Kirksey MA, Haskins SC, Cheng J, et al. Local anesthetic peripheral nerve block adjuvants for prolongation of analgesia: a systematic qualitative review. PLoS One. 2015;10:e0137312.

Pöpping DM, Elia N, Marret E, et al. Clonidine as an adjuvant to local anesthetics for peripheral nerve and plexus blocks. Anesthesiology. 2009;111:406–15.

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15 Ekim 2022

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