Arı Zehri ve Kullanım Alanları
Özet
Bal arılarından elde edilen ve apitoksin olarak da bilinen arı zehri, antik çağlardan beri tamamlayıcı tıp uygulaması olan apiterapi kapsamında yaygın şekilde kullanılan, farmakolojik öneme sahip son derece değerli doğal bir üründür. İşçi arıların karın bölgesindeki bezlerden salgılanan bu asidik ve bazik sıvı karışım, oda sıcaklığında kuruyarak kristalleşir ve en yüksek üretim seviyesine arılar on iki günlük yaşa ulaştığında erişir. Arı zehrinin %88'lik kısmı sudan oluşurken, kalan %12'lik kuru madde kısmı melittin (%40-50), apamin, adolapin gibi peptitler ile fosfolipaz A2, hyaluronidaz gibi enzimler ve aktif aminlerden meydana gelir. Klinik düzeyde canlı arı sokması, enjeksiyon veya arı zehri akupunkturu olmak üzere üç farklı yöntemle uygulanan bu doğal madde; güçlü antiinflamatuar, antioksidan, antimikrobiyal, antiviral ve analjezik özellikler barındırır. Romatoid artrit, multipl skleroz, bel ağrısı, yara iyileşmesi ve egzama gibi cilt rahatsızlıklarında olumlu terapötik sonuçlar sunar. Son klinik ve laboratuvar araştırmaları, ana biyoaktif bileşen melittinin meme, karaciğer ve akciğer gibi çeşitli kanser türlerinde tümör hücrelerini seçici olarak öldürerek küçülttüğünü, ayrıca alzheimer ile parkinson gibi nörodejeneratif hastalıklara karşı koruyucu bir kalkan oluşturduğunu kanıtlamıştır. Bununla birlikte, arı zehri anafilaksi riski ve sitotoksik etkiler taşıdığı için arıtılarak son derece büyük bir dikkatle uygulanmalıdır.
Bee venom, also known as apitoxin and obtained from honey bees, is a highly valuable natural product of pharmacological importance that has been widely used since ancient times within the scope of apitherapy, a complementary medicine practice. Secreted from glands in the abdominal region of worker bees, this acidic and basic liquid mixture crystallizes by drying at room temperature and reaches its peak production level when bees reach twelve days of age. While 88% of bee venom consists of water, the remaining 12% of dry matter is composed of peptides such as melittin (40-50%), apamin, and adolapin, as well as enzymes like phospholipase A2 and hyaluronidase, and active amines. Applied clinically through three different methods—live bee stings, injection, or bee venom acupuncture—this natural substance possesses strong anti-inflammatory, antioxidant, antimicrobial, antiviral, and analgesic properties. It offers positive therapeutic results in skin disorders such as rheumatoid arthritis, multiple sclerosis, back pain, wound healing, and eczema. Recent clinical and laboratory research has proven that melittin, the main bioactive component, selectively kills tumor cells to reduce tumor size in various cancer types including breast, liver, and lung, and also creates a protective shield against neurodegenerative diseases such as Alzheimer's and Parkinson's. However, since bee venom carries a risk of anaphylaxis and cytotoxic effects, it must be purified and administered with extreme caution.
Referanslar
Genç F, Dodoloğlu A. Arıcılığın temel esasları. Atatürk Üniversitesi Ziraat Fakültesi, Ders Yayınları, No: 166, 338 s, Erzurum; 2002.
Maitip J, Mookhploy W, Khorndork S, et al. Comparative study of antimicrobial properties of bee venom extracts and melittins of honey bees. Antibiotics, 2021; 10, 1503. https://doi.org/10.3390/antibiotics10121503.
Shimpi R, Chaudhari P, Deshmukh R, et al. A review: pharmacotherapeutics of bee venom. World Journal of Pharmacy and Pharmaceutical Sciences, 2016; 5, 656-67.
Saleh R. Bee venom therapy for cancer: a literature review. International Journal of Scientific & Engineering Research, 2017; 8,11,590. ISSN 2229-5518.
Altıntaş L, Bektaş N. Apiterapi: Arı Zehri. Uludağ Arıcılık Dergisi, 2019; 19 (1), 82-95.
Sig AK, Güney M, Sig ÖÖ, et al. Bee venom: A medical perspective. Turkish Journal of Clinics and Laboratory, 2019; 10, 414-421.
Tekeoğlu İ, Akdoğan M. Bal arısı zehirinin tamamlayıcı tıptaki güncel yeri. Ankara Akupunktur, 2016; 4 (1), 8-14.
Şahinler N, Toy NÖ, Şahinler S. Arı zehri ve kulanım alanları. 4th International Anatolian Agriculture. Food, Environment and Biology Congress -2019.
Derebaşı E, Canbakal KE. Arı zehirinin kimyasal yapısı ve tıbbi çalışmalarda kullanımı. Arıcılık Araştırma Dergisi, 2009; 1(2), 32-34.
Abd El-Wahed AA, Khalifa SAM, Sheikh BY, et al. Chapter 13 - Bee venom composition: from chemistry to biological activity. Studies in Natural Products Chemistry, 2019; 60, 459-484. https://doi.org/10.1016/B978-0-444-64181-6.00013-9.
Gülmez Y, Aydın A, Can İ, et al. Cellular toxicity and biological activities of honey bee (Apis mellifera L.) venom. Marmara Pharmaceutical Journal, 2017; 21(2), 251-260. DOI: 10.12991/marupj.300329.
Keil TWM, Baldassi D, Merkel OM. T-cell targeted pulmonary siRNA delivery for the treatment of asthma. WIREs Nanoscience & Nanotechnology, 2020; 12:e1634. wires.wiley.com/nanomed. https://doi.org/10.1002/wnan.1634.
Raghuraman H, Chattopadhyay A. Melittin: a membrane-active peptide with diverse functions. Bioscience Reports, 2007; 27, 189-223.
Zhang S, Liu Y, Ye Y, et al. Bee venom therapy: Potential mechanisms and therapeutic applications. Toxicon, 2018; 148, 64-73.
Cherniacka P, Govorushk S. To bee or not to bee: The potential efficacy and safety of bee venom acupuncture in humans. Toxicon, 2018; 154, 74-78.
Mansour GH, El-Magd, MA, Mahfouz DH, et al. Bee venom and its active component Melittin synergistically potentiate the anticancer effect of Sorafenib against HepG2 cells. Bioorganic Chemistry, 2021; 116, 105329.
Lee YM, Cho SN, Son E, et al. Apamin from bee venom suppresses inflammation in a murine model of goutyarthritis. Journal of Ethnopharmacology, 2020; 257, 112860. https://doi.org/10.1016/j.jep.2020.112860.
Kim JY, Lee SJ, Maeng YI, et al. Protective effects of bee venom against endotoxemia-related acute kidney ınjury in mice. Biology, 2020; 9, 154. doi:10.3390/biology9070154. www.mdpi.com/journal/biology.
Nguyen CD, Lee G. Neuroprotective activity of melittin—the main component of bee venom—against oxidative stress ınduced by aβ25–35 in ın vitro and ın vivo models. Antioxidants, 2021; 10, 1654. https://doi.org/10.3390/antiox10111654.
Zhang SF, Chen Z. Melittin exerts an antitumor effect on non‑small cell lung cancer cells. Molecular Medicine Reports, 2017; 16, 3581-3586.
Orsolic N. Bee venom in cancer therapy. Cancer Metastasis Review, 2012; 31, 173‑194.
Heinen TE, da Veiga AB. Arthropod venoms and cancer. Toxicon, 2011; 57, 497‑511.
Hou KK, Pan H, Lanza GM. Wickline, S.A. Melittin derived peptides for nanoparticle based siRNA transfection. Biomaterials, 2013; 34, 3110e3119.
Kurek-Górecka A, Komosinska-Vassev K, Rzepecka-Stojko A, et al. Bee venom in wound healing. Molecules, 2021; 26(148), 1-13. https://doi.org/10.3390/molecules26010148.
Sharma R, Jhorar R, Goyal K, et al. Nanotechnological interventions in HIV drug delivery and therapeutics. Biointerface Research in Applied Chemistry, 2014; 4(4), 820-831. ISSN 2069-5837.
